Nanoparticle-based immunoengineering strategies for enhancing cancer immunotherapy

Dang, Bao-Toan Nguyen; Kwon, Taeg Kyu; Lee, Sooyeun; Jeong, Jee-Heon; Yook, Simmyung

doi:10.1016/j.jconrel.2023.12.007

Cited by 15 publications

(1 citation statement)

References 258 publications

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“…In this way, side effects on normal organs and tissues can be significantly reduced. Moreover, the immunotherapeutic strategy also provides long-term protection against tumor recurrence due to the induction of the immunological memory [38].…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Immunotherapy of Diseases and Nanotechnology: Current State and Prospects

Piminov,

Sahaidak-Nikitiuk,

Kvitchata

et al. 2024

J. Org. Pharm. Chem.

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Nanotechnology can be used to treat a number of diseases, which are currently the main cause of death in the world, and allow to achieve the desired therapeutic effect for the patient. This mini-review focuses on the analysis of scientific literary sources dealing with the application of nanotechnology in the immunotherapy of diseases and covers the period from 2016 to 2022. In particular, it provides an overview of recently discovered nanotechnologies (including immunomodulatory nanosystems) used for the prevention and treatment of various diseases, including cancer, infectious, inflammatory, and autoimmune diseases. The review also discusses the role of nanosystems in cancer immunotherapy. Additional attention is paid to nanomaterials with new structures, properties, and functions, which are used in the modern practice of treating viral and bacterial infections. A part of the paper is devoted to nanoparticles that enhance the effect of immunosuppressive cells in the treatment of inflammatory and autoimmune diseases. The analysis performed clearly demonstrates the relevance of nanotechnologies for the use in the immunotherapy of diseases. We hope it will allow researchers to identify new areas for using nanoparticles in the treatment of diseases of various etiologies.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Immunotherapy of Diseases and Nanotechnology: Current State and Prospects

Piminov,

Sahaidak-Nikitiuk,

Kvitchata

et al. 2024

J. Org. Pharm. Chem.

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Enhancing X‐Ray Sensitization with Multifunctional Nanoparticles

Liu,

Wu,

Chen

et al. 2024

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In the progression of X‐ray‐based radiotherapy for the treatment of cancer, the incorporation of nanoparticles (NPs) has a transformative impact. This study investigates the potential of NPs, particularly those comprised of high atomic number elements, as radiosensitizers. This aims to optimize localized radiation doses within tumors, thereby maximizing therapeutic efficacy while preserving surrounding tissues. The multifaceted applications of NPs in radiotherapy encompass collaborative interactions with chemotherapeutic, immunotherapeutic, and targeted pharmaceuticals, along with contributions to photodynamic/photothermal therapy, imaging enhancement, and the integration of artificial intelligence technology. Despite promising preclinical outcomes, the paper acknowledges challenges in the clinical translation of these findings. The conclusion maintains an optimistic stance, emphasizing ongoing trials and technological advancements that bolster personalized treatment approaches. The paper advocates for continuous research and clinical validation, envisioning the integration of NPs as a revolutionary paradigm in cancer therapy, ultimately enhancing patient outcomes.

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