Nanoparticle mediated brain targeted delivery of gallic acid:<i>in vivo</i>behavioral and biochemical studies for improved antioxidant and antidepressant-like activity

Nagpal, Kalpana; Singh, Shailendra Kumar; Mishra, Dina Nath

doi:10.3109/10717544.2012.738437

Cited by 53 publications

(38 citation statements)

References 61 publications

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“…Likewise, injectable, in situ-gelling forms of agarose have been used in combination with lipid microtubules loaded with bioactive molecules after SCI [49,61]. Bioactive molecules have been delivered to the CNS with chitosan-based hydrogels [62][63][64][65][66][67], microparticles [68][69][70] or nanoparticles [71][72][73][74][75][76][77][78][79][80]. Chitosan-based biomaterials in particular have largely been explored for delivery through the nasal route.…”

Section: Hydrogels As Drug Delivery Platformsmentioning

confidence: 99%

“…The mucoadhesive property of chitosan increases the dwell time and concentration of the deliverables at the site which results in a higher local concentration and an increase of absorption. A variety of bioactive molecules including antibiotics [70], insulin [65,81], anti-viral [62,63,80] and antidepressants [78,79] have been successfully delivered into the CNS using chitosanbased biomaterials. For example, Thoren et al successfully used chitosan-based materials to deliver insulin-like growth factor 1 as a possible treatment of Alzheimer's disease or stroke [81].…”

Section: Figurementioning

confidence: 99%

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Advanced biomaterials for repairing the nervous system: what can hydrogels do for the brain?

et al. 2014

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Section: Hydrogels As Drug Delivery Platformsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Advanced biomaterials for repairing the nervous system: what can hydrogels do for the brain?

et al. 2014

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“…e higher the CH: TPP ratio and, hence, the lower the crosslinking capacity, the greater the shift of the peak was. e location of the peak at the highest temperature could be attributed to the gallic acid free in the matrix whose melting is produced at 250°C [15,16].…”

Section: Ermal Analysismentioning

confidence: 99%

Structural Insight into Chitosan Supports Functionalized with Nanoparticles

Lamarra

Damonte

Rivero

et al. 2018

Advances in Materials Science and Engineering

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e incorporation of suspensions of nanoparticles functionalized with gallic acid (GA) was used as a strategy to obtain nanocomposite active films with different both chitosan : tripolyphosphate (CH : TPP) and nanoparticles:chitosan (N : CH) ratios. e thermal analysis carried out by modulated differential scanning calorimetry (MDSC) allowed observing the shift of an endothermic event towards higher temperatures with a greater N : CH ratio. Analyzing ATR-FTIR spectra through principal component analysis (PCA) can be inferred that the incorporation of the nanoparticles produced a discrimination of the samples into clusters when the region 1400-1700 cm −1 was considered. e decrease in crystalline size with the inclusion of nanoparticles (N A and N B ) proved the existence of interactions among CH, TPP, and GA, resulting in a more amorphous structure. e positron annihilation lifetime spectroscopy (PALS) technique was adequate to correlate the glass transition temperatures (T g ) obtained by using the MDSC technique with parameters τ 2 and I 2 ascribed to the annihilation of positrons in the interface. e cross section of nanocomposites obtained by scanning electron microscopy (SEM) clearly showed a homogeneous distribution of the nanoparticles without aggregation, suggesting their compatibility with the CH matrix. By virtue of the obtained results, the nanocomposites with the greatest nanoparticle proportion and the highest TPP concentration attained significant modifications in relation to CH matrices because of the crosslinking of the biopolymer with GA and TPP.

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“…The chitosan and tri-poly phosphate pentasodium (TPP) were combined electro-statically entrapping the drug followed by coating with tween 80. 9,10) Briefly, to specified concentration of chitosan solution (CS) in 2% acetic acid solution (pH 5.6) containing constant amount of drug (50 mg), an aqueous solution of TPP (Chitosan : TPP= 3 : 1) was added dropwise and stirred for 1 h using magnetic stirrer followed by addition of specified concentration of tween 80 with continuous stirring. Thereafter, the dispersion was centrifuged at 15000 rpm for 60 min at 10°C so as to collect nanoparticles as pellets.…”

mentioning

confidence: 99%

“…The nanoparticulate drug delivery system has been used for targeting the drugs to brain, as solid lipid nanoparticles or coating them with non ionic surfactants like tween 80, poloxamine 908 etc. 5,[7][8][9][10] In order to improve the brain uptake of MH, nanoparticulate drug delivery system may serve as an efficient tool (with suitable bio-fabrication) to maximize BBB permeability.…”

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confidence: 99%

Formulation, Optimization, <i>in Vivo</i> Pharmacokinetic, Behavioral and Biochemical Estimations of Minocycline Loaded Chitosan Nanoparticles for Enhanced Brain Uptake

Nagpal

Singh

Mishra

2013

CHEMICAL & PHARMACEUTICAL BULLETIN

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The minocycline hydrochloride (MH), at higher doses, is useful in the treatment of neurodegenerative disorders and owing to its antioxidant potential, it may have nootropic effects. MH loaded nanoparticles (MHNP) were coated with tween 80 (cMHNP) to improve its brain uptake followed by their optimization employing two factor-three level (3 2 ) central composite design (CCD) in order to minimize particle size and maximize drug entrapment efficiency (DEE) and validated. The optimized formulations were further subjected to in vitro drug release study; in vivo biodistribution studies in male wistar rats. The pharmacodynamic study was carried out using elevated plus maze (EPM) and Morris water maze (MWM) behavioral models for nootropic activity in swiss albino mice; and biochemical estimations (acetylcholine esterase, reduced glutathione, malondialdehyde and brain nitrite level). After intravenous (i.v.) administration, the concentration of MH in brain of cMHNP (6.21±0.64 µg/mL) treated rats was significantly higher with MH solution treated (0.70±0.06 µg/mL) as well as MHNP (1.03±0.12 µg/mL) treated animals. Pharmacodynamic studies revealed a significant improvement in memory of MH, MHNP and cMHNP treated swiss albino mice than saline treated control group. However, cMHNP revealed maximum decrease in transfer latency (TL) in EPM and maximum increase in time spent in target quadrant (TSTQ) in MWM. Although cMHNP did not produce significant change in brain acetylcholinesterase, but, significantly increased reduced glutathione, malondialdehyde and reduced brain nitrite level as compared to saline, MH solution and MHNP treated groups. The results suggest that cMHNP is a promising candidate for improved brain uptake of MH with better no o tro pic effect.

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Nanoparticle mediated brain targeted delivery of gallic acid:in vivobehavioral and biochemical studies for improved antioxidant and antidepressant-like activity

Cited by 53 publications

References 61 publications

Advanced biomaterials for repairing the nervous system: what can hydrogels do for the brain?

Advanced biomaterials for repairing the nervous system: what can hydrogels do for the brain?

Structural Insight into Chitosan Supports Functionalized with Nanoparticles

Formulation, Optimization, <i>in Vivo</i> Pharmacokinetic, Behavioral and Biochemical Estimations of Minocycline Loaded Chitosan Nanoparticles for Enhanced Brain Uptake

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