Nanoparticles, a Double-Edged Sword with Oxidant as Well as Antioxidant Properties—A Review

Samrot, Antony V.; Singh, Sanjay Preeth Ram; Rajalakshmi, Deenadhayalan; Rajesh, V.; Padmanaban, Sathiyamoorthy; Radhakrishnan, Kamalakannan

doi:10.3390/oxygen2040039

Cited by 46 publications

(18 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These compounds possess antioxidant properties and can bind to the surface of AgNPs, enhancing their scavenging ability and promoting electron transfer. Moreover, the size, shape, and surface properties of nanoparticles can also affect their antioxidant activity [ 121 ]. Smaller nanoparticles have a higher surface area-to-volume ratio, which allows for more efficient scavenging of free radicals.…”

Section: Resultsmentioning

confidence: 99%

Rosmarinic Acid-Rich Perilla frutescens Extract-Derived Silver Nanoparticles: A Green Synthesis Approach for Multifunctional Biomedical Applications including Antibacterial, Antioxidant, and Anticancer Activities

Netala,

Hou,

Sana

et al. 2024

Molecules

View full text Add to dashboard Cite

This study describes a simple, cost-effective, and eco-friendly method for synthesizing silver nanoparticles using a rosmarinic acid extract from Perilla frutescens (PFRAE) as the bioreduction agent. The resulting nanoparticles, called PFRAE-AgNPs, were characterized using various analytical techniques. The UV–Vis spectrum confirmed the formation of PFRAE-AgNPs, and the FTIR spectrum indicated the participation of rosmarinic acid in their synthesis and stabilization. The XRD pattern revealed the crystal structure of PFRAE-AgNPs, and the TEM analysis showed their spherical morphology with sizes ranging between 20 and 80 nm. The DLS analysis indicated that PFRAE-AgNPs were monodispersed with an average diameter of 44.0 ± 3.2 nm, and the high negative zeta potential (−19.65 mV) indicated their high stability. In the antibacterial assays, the PFRAE-AgNPs showed potent activity against both Gram-positive (Bacillus subtilis and Staphylococcus aureus) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacterial pathogens, suggesting that they could be used as a potential antibacterial agent in the clinical setting. Moreover, the antioxidant activity of PFRAE-AgNPs against DPPH and ABTS radical scavengers highlights their potential in the treatment of various oxidative stress-related diseases. PFRAE-AgNPs also demonstrated significant anticancer activity against a range of cell lines including human colon cancer (COLO205), human prostate carcinoma (PC-3), human lung adenocarcinoma (A549), and human ovarian cancer (SKOV3) cell lines suggesting their potential in cancer therapy. The nanoparticles may also have potential in drug delivery, as their small size and high stability could enable them to cross biological barriers and deliver drugs to specific target sites. In addition to the aforementioned properties, PFRAE-AgNPs were found to be biocompatible towards normal (CHO) cells, which is a crucial characteristic for their application in cancer therapy and drug delivery systems. Their antibacterial, antioxidant, and anticancer properties make them promising candidates for the development of new therapeutic agents. Furthermore, their small size, high stability, and biocompatibility could enable them to be used in drug delivery systems to enhance drug efficacy and reduce side effects.

show abstract

Section: Resultsmentioning

confidence: 99%

Rosmarinic Acid-Rich Perilla frutescens Extract-Derived Silver Nanoparticles: A Green Synthesis Approach for Multifunctional Biomedical Applications including Antibacterial, Antioxidant, and Anticancer Activities

Netala,

Hou,

Sana

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

“…Numerous dietary [83] as well as synthetic antioxidants are reported, acting as effective therapeutic agents [84]. Nano-antioxidants are nanomaterials that are synthesized in order to prevent OS [85,86].…”

Section: Nanomaterials and Prevention Of Oxidative Stressmentioning

confidence: 99%

The Dual Role of Oxidative-Stress-Induced Autophagy in Cellular Senescence: Comprehension and Therapeutic Approaches

et al. 2023

View full text Add to dashboard Cite

The contemporary lifestyle of the last decade has undeniably caused a tremendous increase in oxidative-stress-inducing environmental sources. This phenomenon is not only connected with the rise of ROS levels in multiple tissues but is also associated with the induction of senescence in different cell types. Several signaling pathways that are associated with the reduction in ROS levels and the regulation of the cell cycle are being activated, so that the organism can battle deleterious effects. Within this context, autophagy plays a significant role. Through autophagy, cells can maintain their homeostasis, as if it were a self-degradation process, which removes the “wounded” molecules from the cells and uses their materials as a substrate for the creation of new useful cell particles. However, the role of autophagy in senescence has both a “dark” and a “bright” side. This review is an attempt to reveal the mechanistic aspects of this dual role. Nanomedicine can play a significant role, providing materials that are able to act by either preventing ROS generation or controllably inducing it, thus functioning as potential therapeutic agents regulating the activation or inhibition of autophagy.

show abstract

“…Their metabolic products can induce oxidative stress in cells producing ROS while they are degraded by enzymes or they can react with cell wall components (fatty acids, nucleotides and others); both situations can cause cytotoxicity (Manke et al, 2013). Another situation is the production of reactive nitrogen species (RNS) that combined with ROS can cause genotoxicity and oncogenesis (Samrot et al, 2022).…”

Section: Molecular Fitting Procedures Referencesmentioning

confidence: 99%

Biopharmaceutical and nanotoxicological aspects of cyclodextrins for non‐invasive topical treatments: A critical review

Riccio

Meneguin

Baveloni

et al. 2023

J of Applied Toxicology

View full text Add to dashboard Cite

Cyclodextrins are nanometric cyclic oligosaccharides with amphiphilic characteristics that increase the stability of drugs in pharmaceutical forms and bioavailability, in addition to protecting them against oxidation and UV radiation. Some of their characteristics are low toxicity, biodegradability, and biocompatibility. They are divided into α‐, β‐, and γ‐cyclodextrins, each with its own particularities. They can undergo surface modifications to improve their performances. Furthermore, their drug inclusion complexes can be made by various methods, including lyophilization, spray drying, magnetic stirring, kneading, and others. Cyclodextrins can solve several problems in drug stability when incorporated into dosage forms (including tablets, gels, films, nanoparticles, and suppositories) and allow better topical biological effects of drugs at administration sites such as skin, eyeballs, and oral, nasal, vaginal, and rectal cavities. However, as they are nanostructured systems and some of them can cause mild toxicity depending on the application site, they must be evaluated for their nanotoxicology and nanosafety aspects. Moreover, there is evidence that they can cause severe ototoxicity, killing cells from the ear canal even when applied by other administration routes. Therefore, they should be avoided in otologic administration and should have their permeation/penetration profiles and the in vivo hearing system integrity evaluated to certify that they will be safe and will not cause hearing loss.

show abstract

Nanoparticles, a Double-Edged Sword with Oxidant as Well as Antioxidant Properties—A Review

Cited by 46 publications

References 121 publications

Rosmarinic Acid-Rich Perilla frutescens Extract-Derived Silver Nanoparticles: A Green Synthesis Approach for Multifunctional Biomedical Applications including Antibacterial, Antioxidant, and Anticancer Activities

Rosmarinic Acid-Rich Perilla frutescens Extract-Derived Silver Nanoparticles: A Green Synthesis Approach for Multifunctional Biomedical Applications including Antibacterial, Antioxidant, and Anticancer Activities

The Dual Role of Oxidative-Stress-Induced Autophagy in Cellular Senescence: Comprehension and Therapeutic Approaches

Biopharmaceutical and nanotoxicological aspects of cyclodextrins for non‐invasive topical treatments: A critical review

Contact Info

Product

Resources

About