Nanoparticles and prostate cancer

Garg, Ashish; Garg, Sweta; Swarnakar, Nitin K.

doi:10.1016/b978-0-12-819793-6.00012-6

Cited by 4 publications

(2 citation statements)

References 246 publications

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“…In general, a nanosphere is solid sphere and mostly adsorbs therapeutics on its surfaces while nanocapsules act as a reservoir which encapsulates substances that are bound to a cavity of either lipid or water core. [ 155 ] Nanorods and nanostars are also in use as nanocarriers however the complexity of designing these structures has kept them away from being widely used.…”

Section: Various Polymeric Nanocarriers For Drug Deliverymentioning

confidence: 99%

Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

2022

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Carriers are equally important as drugs. They can substantially improve bioavailability of cargos and safeguard healthy cells from toxic effects of certain therapeutics. Recently, polymeric nanocarriers (PNCs) have achieved significant success in delivering drugs not only to cells but also to subcellular organelles. Variety of natural sources, availability of different synthetic routes, versatile molecular architectures, exploitable physicochemical properties, biocompatibility, and biodegradability have presented polymers as one of the most desired materials for nanocarrier design. Recent innovative concepts and advances in PNC-associated nanotechnology are providing unprecedented opportunities to engineer nanocarriers and their functions. The efficiency of therapeutic loading has got considerably increased. Structural design-based varieties of PNCs are widely employed for the delivery of small therapeutic molecules to genes, and proteins. PNCs have gained ever-increasing attention and certainly paves the way to develop advanced nanomedicines. This article presents a comprehensive investigation of structural design-based varieties of PNCs and the influences of their physicochemical properties on drug delivery profiles with perspectives highlighting the inevitability of incorporating both the multi-stimuli-responsive and multi-drug delivery properties in a single carrier to design intelligent PNCs as new and emerging research directions in this rapidly developing area.

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Section: Various Polymeric Nanocarriers For Drug Deliverymentioning

confidence: 99%

Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

2022

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“…Their classification is based on the positional characteristics of the drugs and polymers, as shown schematically in Figure 4a and b. Nanospheres contain drug molecules within a uniformly dispersed polymeric matrix, while nanocapsules entrap the drug molecules inside their core, a cavity surrounded by a polymeric membrane that acts as a shell [25].…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Aliphatic Polyester Nanoparticles for Drug Delivery Systems

Kreua-ongarjnukool¹,

Soomherun²,

Niyomthai³

et al. 2022

Smart Drug Delivery

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Drug delivery systems using aliphatic polyester nanoparticles are usually prepared via an emulsion process. These nanoparticles can control drug release and improve pharmacokinetics. Aliphatic polyesters are linear polymers containing ester linkages, showing sensitivity to hydrolytic degradation. The byproducts then promote autocatalytic degradation. These byproducts could enter the Krebs cycle and be eliminated from the body, resulting in the high biocompatibility of these nanoparticles. The properties of these polyesters are linked to the drug release rate due to biodegradation, i.e., polymer crystallinity, glass transition temperature, polymer hydrophobicity, and molecular weight (MW), all of which relatively influence hydrolysis. Mathematical equations have been used to study the factors and mechanisms that affect drug dissolution compared to experimental release data. The equations used as models for predicting the kinetics of drug release include the zero-order, first-order, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas equations. Aliphatic polyester-based controlled drug delivery has surrounded much of the current activity in the estimation parameters of nanoparticles and stimulated additional research. Polymeric nanoparticles have potential in a wide range of applications, such as in biotechnology, vaccine systems, and the pharmaceutical industry. The main goal of this chapter is to discuss aliphatic polyester nanoparticles as drug carrier systems.

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