Nanoparticles as a Future Alternative Against Multiple Drug Resistance

Ansari, Md. Meraj; Kuche, Kaushik; Ghadi, Rohan; Date, Tushar; Chaudhari, Dasharath; Ansari, Faiyaz Ahmad; Khan, Rafaqat Ali; Vyawahare, Akshay; Jain, Sanyog

doi:10.1007/978-3-030-84126-3_18

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“…Antimicrobial resistance (AMR) in bacteria is recently recognized as a “hidden pandemic” at the global healthcare platform . Inorganic metal and metal oxide nanoparticles have shown promising potential addressing the challenge of continuously emerging AMR in bacteria. , Metal and metal oxide nanoparticles can exhibit bactericidal efficacy via various mechanisms, mainly as generation of reactive oxygen species (ROS), metal cations release, physical damage to the cellular membrane, and chemical binding with functional membrane proteins . Released metal ions from the metallic and metal oxide nanoparticles can disintegrate DNA helical strands and can also inactivate thiol (-SH) groups in metabolic proteins .…”

Section: Introductionmentioning

confidence: 99%

In Situ Microscopic Studies on the Interaction of Multi-Principal Element Nanoparticles and Bacteria

et al. 2023

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Multi-principal element nanoparticles are an emerging class of materials with potential applications in medicine and biology. However, it is not known how such nanoparticles interact with bacteria at nanoscale. In the present work, we evaluated the interaction of multi-principal elemental alloy (FeNiCu) nanoparticles with Escherichia coli (E. coli) bacteria using the in situ graphene liquid cell (GLC) scanning transmission electron microscopy (STEM) approach. The imaging revealed the details of bacteria wall damage in the vicinity of nanoparticles. The chemical mappings of S, P, O, N, C, and Cl elements confirmed the cytoplasmic leakage of the bacteria. Our results show that there is selective release of metal ions from the nanoparticles. The release of copper ions was much higher than that for nickel while the iron release was the lowest. In addition, the binding affinity of bacterial cell membrane protein functional groups with Cu, Ni, and Fe cations is found to be the driving force behind the selective metal cations’ release from the multi-principal element nanoparticles. The protein functional groups driven dissolution of multielement nanoparticles was evaluated using the density functional theory (DFT) computational method, which confirmed that the energy required to remove Cu atoms from the nanoparticle surface was the least in comparison with those for Ni and Fe atoms. The DFT results support the experimental data, indicating that the energy to dissolve metal atoms exposed to oxidation and/or the to presence of oxygen atoms at the surface of the nanoparticle catalyzes metal removal from the multielement nanoparticle. The study shows the potential of compositional design of multi-principal element nanoparticles for the controlled release of metal ions to develop antibacterial strategies. In addition, GLC-STEM is a promising approach for understanding the nanoscale interaction of metallic nanoparticles with biological structures.

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