Nanoparticles as vehicles for delivery of photodynamic therapy agents

Béchet, Denise; Couleaud, Pierre; Frochot, Céline; Viriot, Marie‐Laure; Guillemin, François; Barberi‐Heyob, Muriel

doi:10.1016/j.tibtech.2008.07.007

Cited by 713 publications

(552 citation statements)

References 64 publications

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“…Nevertheless, these observations contradict the predictions of some authors who argue that increasing the lipophilicity of compounds, causes a rise in their aggregation tendencies [12,41].…”

Section: M)contrasting

confidence: 79%

Spectroscopic characterization and aggregation of azine compounds in different media

Urrutia¹,

Ortiz²

2013

Chemical Physics

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In this study, we have reported for the first time a complete experimental investigation on the compound Neutral Red and the new monobrominated derivative in different media as a function of the concentration. These compounds belong to the quinone-imine class of dyes and have good potential to be applied as photosensitizers in Photodynamic Therapy.Although the aggregation of Neutral Red has been reported by several authors, this has not been thoroughly evaluated due to spectral changes occurring depending on the solvent and concentration of dye.

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Section: M)contrasting

confidence: 79%

Spectroscopic characterization and aggregation of azine compounds in different media

Urrutia¹,

Ortiz²

2013

Chemical Physics

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“…Necrosis usually occurs only in response to a pathologic form of cellular injury. Oxidative stress causes damage to cellular (macro)molecules such as nucleic acids, proteins and lipids [1][2][3][4]. This is two steps process process, where the photosensitizer absorbs a photon of light in the ground state and this promotes the PS to the short-live excited state.…”

Section: Introductionmentioning

confidence: 99%

“…Each of the currently commercially available photosensitizers has specific characteristics, but none of them is an ideal agent. Most of the PS are hydrophobic and can aggregate very easily in aqueous media which can affect their photophysical, chemical and biological properties [2].…”

Section: Introductionmentioning

confidence: 99%

Nanodrug applications in photodynamic therapy

Paszko

Ehrhardt

Senge

et al. 2011

Photodiagnosis and Photodynamic Therapy

326

215

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SummaryPhotodynamic therapy (PDT) has developed over last century and is now becoming a more widely used medical tool having gained regulatory approval for the treatment of various diseases such as cancer and macular degeneration. It is a two-step technique in which delivery of a photosensitizing drug is followed by irradiation of light. Activated photosensitizers transfer energy to molecular oxygen which results in generation of reactive oxygen species which in turn cause cells apoptosis or necrosis. Although this modality has significantly improved quality of life and survival time for many cancer patients it still offers significant potential for further improvement. In addition to the development of new PDT drugs, the use of nanosized carriers for photosensitizers is a promising approach which might improve the efficiency of photodynamic activity and which can overcome many side effects associated with classic photodynamic therapy. This review aims at highlighting the different types of nanomedical approaches currently used in PDT and outlines future trends and limitations of nanodelivery of photosensitizers. PDT -photodynamic therapy; PGA -poly(glycolic acid); PGLA -poly(D,L-lactide-coglycolide); PLA -poly(lactic acid); PS -photosensitizer; PEG -polyethylene glycol; ALA  aminolevulinic acid; m-THPC  5,10,15,20-tetra-(m-hydroxyphenyl)chlorine; m-THPP  meso-tetra(p-hydroxyphenyl); PpIX  protoporphyrin; Hp  hematoporphyrin; Pc4  silicon phthalocyanine; Ig  immunoglobulin; Tf  transferrin; TfR  transferrin receptor; VEGF  vascular endothelial growth factor; EPR  enhanced permeability and retention effect; FRET  fluorescence resonance energy transfer; MRI  magnetic resonance imaging; RES  reticuloendothelial system; ROS  reactive oxygen species; NP  nanoparticle; ND -nanodiamonds; SNP  silica nanoparticle; AMD  age-related macular degeneration; CNV  choroidal neovascularization; PTT  photothermal therapy;

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“…These nanoparticles and nanomaterials have been applied in various fields, such as in electronics, sensors, and even in the biomedical space, due to the immense range of useful and diverse properties that are intrinsic to certain nanoparticles. Nanoparticles can be grouped into different types, such as carbon-based nanomaterials, metal nanoparticles, denderimers and nanocomposites (1)(2)(3)(4). Carbon-based nanomaterials are well known for their innumerable applications in all fields of science and technology.…”

Section: Introductionmentioning

confidence: 99%

Artemisia herba-alba Asso eco-friendly reduced few-layered graphene oxide nanosheets: structural investigations and physical properties

Khenfouch

Ndimba

Diallo

et al. 2016

Green Chemistry Letters and Reviews

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Nowadays graphene is universally known as a promising material. Hence, the development of ecofriendly synthesis methods for this material is of great importance. This study reports on the biosynthesis of graphene by a green chemistry process using Artemisia herba-alba Asso (AHAA) natural extract. Moreover, this work reports on the physical properties, including surface/ interface and optical and electrical properties of the obtained graphene sheets. UV-VIS, Raman, XPS spectroscopies and TEM microscopy investigations confirmed the reduction, and the conversion of graphene oxide to few-layered reduced graphene oxide as well as the efficiency of this plant extract compared with several natural extracts and chemical agents. Furthermore, it was found that the optical and electrical properties of graphene can be modulated and controlled via this eco-friendly cost-effective process. Hence, AHAA can be an effective chelating agent to produce graphene sheets. ARTICLE HISTORY

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Nanoparticles as vehicles for delivery of photodynamic therapy agents

Cited by 713 publications

References 64 publications

Spectroscopic characterization and aggregation of azine compounds in different media

Spectroscopic characterization and aggregation of azine compounds in different media

Nanodrug applications in photodynamic therapy

Artemisia herba-alba Asso eco-friendly reduced few-layered graphene oxide nanosheets: structural investigations and physical properties

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