Nanoparticles based on albumin: Preparation, characterization and the use for 5-flurouracil delivery

Wilson, Barnabas; Ambika, T.V.; Patel, Rajeshri D.; Jenita, Josephine Leno; Priyadarshini, S.R.B.

doi:10.1016/j.ijbiomac.2012.07.014

Cited by 66 publications

(42 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With regard to conjugation, a highly compatible and specific ligand is essential for active targeting, and should be able to bind selectively to a particular type of receptor on the target cells. 21 Curcumin (Ccn), a hydrophobic polyphenol structure, is extracted from the rhizomes of Curcuma longa 22 and has a number of medicinal and therapeutic properties, including anti-inflammatory, antiseptic, antioxidative, and hypolipidemic effects. 23,24 Moreover, emerging evidence shows that Ccn might induce apoptosis or cell cycle arrest in several types of cancer.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and in vitro evaluation of curcumin-loaded albumin nanoparticles surface-functionalized with glycyrrhetinic acid

Li¹,

Chen²,

Deng³

et al. 2015

IJN

View full text Add to dashboard Cite

We have designed and developed curcumin (Ccn)-loaded albumin nanoparticles (BNPs) surface-functionalized with glycyrrhetinic acid (Ccn-BNP-GA) for GA receptor-mediated targeting. Ccn-BNP-GA was prepared by conjugating GA as a hepatoma cell-specific binding molecule onto the surface of BNPs. Ccn-BNP-GA showed a narrow distribution with an average size of 258.8±6.4 nm, a regularly spherical shape, an entrapment efficiency of 88.55%±5.54%, and drug loading of 25.30%±1.58%. The density of GA as the ligand conjugated to BNPs was 140.48±2.784 μg/g bovine serum albumin. Cytotoxicity assay results indicated that Ccn-BNP-GA was significantly more cytotoxic to HepG2 cells and in a concentration-dependent manner. Ccn-BNP-GA also appeared to be taken up to a greater extent by HepG2 cells than undecorated groups, which might be due to the high affinity of GA for GA receptors on the HepG2 cell surface. These cytotoxicity assay results were corroborated by analysis of cell apoptosis and the cell cycle. Further, Ccn-BNP-GA showed an approximately twofold higher rate of cell apoptosis than the other groups. Moreover, proliferation of HepG2 cells was arrested in G 2 /M phase based on cell cycle analysis. These results, which were supported by the GA receptor-mediated endocytosis mechanism, indicate that BNPs surface-functionalized with GA could be used in targeted cancer treatment with high efficacy, sufficient targeting, and reduced toxicity.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and in vitro evaluation of curcumin-loaded albumin nanoparticles surface-functionalized with glycyrrhetinic acid

Li¹,

Chen²,

Deng³

et al. 2015

IJN

View full text Add to dashboard Cite

show abstract

“…Trehalose as an additive seems to provide sufficient protection from lyophilization of HSA protein, contributing to maintaining stability in the solid state [67]. Trehalose containing formulations were superior to mannitol and lactose, exhibiting minimal increases in nanoparticle size and PI following the freeze-drying procedure (Fig 3a,3b) [68].…”

Section: Discussionmentioning

confidence: 97%

Bio-inspired artemether-loaded human serum albumin nanoparticles for effective control of malaria-infected erythrocytes

Sidhaye¹,

Bhuran²,

Zambare³

et al. 2016

Nanomedicine

View full text Add to dashboard Cite

Aim: The intra-erythrocytic development of the malarial parasite is dependent on active uptake of nutrients, including human serum albumin (HSA), into parasitized red blood cells (pRBCs). We have designed HSA-based nanoparticles as a potential drug-delivery option for antimalarials. Methods: Artemether-loaded nanoparticles (AAN) were designed and antimalarial activity evaluated in-vitro/in-vivo using Plasmodium falciparum/Plasmodium berghei species, respectively. Results: Selective internalisation of AAN into Plasmodiuminfected RBCs in preference to healthy erythrocytes was observed using confocal-imaging.In-vitro studies showed 50% dose reduction for AAN as compared to drug-only controls to achieve IC50 levels of inhibition. The nanoparticles exhibited 2-fold higher peak drug concentrations in RBCs with antimalarial activity at 50% of therapeutic doses in P.bergeiinfected mice. Conclusion: HSA-based nanoparticles offer safe and effective approach for selective targeting of antimalarial drugs.

show abstract

“…Therefore, it can be interpreted from first order release kinetics that the drug release rate was dependent on the concentration of drug in CSLAHNPs. Similar findings were reported for biphasic release of 5-fluorouracil loaded ANPs (319). Moreover, the Korsmeyer-Peppas release model showed high correlation for drug release from ETBCSLAHNPs at both pH values.…”

Section: Tem Photomicrograph Of Etb-cslahnps Was Shown Insupporting

confidence: 87%

Design, Development and Evaluation of Erlotinib-Loaded Hybrid Nanoparticles for Targeted Drug Delivery to NonSmall Cell Lung Cancer

Mandal¹

View full text Add to dashboard Cite

Nanoparticles based on albumin: Preparation, characterization and the use for 5-flurouracil delivery

Cited by 66 publications

References 28 publications

Synthesis, characterization, and in vitro evaluation of curcumin-loaded albumin nanoparticles surface-functionalized with glycyrrhetinic acid

Synthesis, characterization, and in vitro evaluation of curcumin-loaded albumin nanoparticles surface-functionalized with glycyrrhetinic acid

Bio-inspired artemether-loaded human serum albumin nanoparticles for effective control of malaria-infected erythrocytes

Design, Development and Evaluation of Erlotinib-Loaded Hybrid Nanoparticles for Targeted Drug Delivery to NonSmall Cell Lung Cancer

Contact Info

Product

Resources

About