Nanoparticles based on gadolinium(iii) and europium(iii) complexes for biovisualization

Zairov, Rustem; Shamsutdinova, Nataliya; Fattakhova, А. N.; Pyataev, A. V.; Abdullin, Albert; Gerasimov, Alexander V.; Gubaidullin, А. Т.; Mustafina, Asiya R.

doi:10.1007/s11172-016-1456-2

Cited by 13 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, interactions of the nanoparticles with inorganic and biological background in physiological media can affect the localization of nanoparticles on cell membrane. Thus, DLS measurements were performed for the aqueous colloids in PBS buffer before and after the protein admixture, since protein corona is well documented factor, affecting both aggregation and cellular uptake behavior of nanoparticles5455. The size increase from ∼100 to ∼500 nm (Table 1 and S7 in SI) is observed from DLS measurements of PSS-stabilized Tb- 1 colloids in water and in PBS buffer (0.1 M).…”

Section: Resultsmentioning

confidence: 99%

High performance magneto-fluorescent nanoparticles assembled from terbium and gadolinium 1,3-diketones

Zairov

Mustafina

Shamsutdinova

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Polyelectrolyte-coated nanoparticles consisting of terbium and gadolinium complexes with calix[4]arene tetra-diketone ligand were first synthesized. The antenna effect of the ligand on Tb(III) green luminescence and the presence of water molecules in the coordination sphere of Gd(III) bring strong luminescent and magnetic performance to the core-shell nanoparticles. The size and the core-shell morphology of the colloids were studied using transmission electron microscopy and dynamic light scattering. The correlation between photophysical and magnetic properties of the nanoparticles and their core composition was highlighted. The core composition was optimized for the longitudinal relaxivity to be greater than that of the commercial magnetic resonance imaging (MRI) contrast agents together with high level of Tb(III)-centered luminescence. The tuning of both magnetic and luminescent output of nanoparticles is obtained via the simple variation of lanthanide chelates concentrations in the initial synthetic solution. The exposure of the pheochromocytoma 12 (PC 12) tumor cells and periphery human blood lymphocytes to nanoparticles results in negligible effect on cell viability, decreased platelet aggregation and bright coloring, indicating the nanoparticles as promising candidates for dual magneto-fluorescent bioimaging.

show abstract

Section: Resultsmentioning

confidence: 99%

High performance magneto-fluorescent nanoparticles assembled from terbium and gadolinium 1,3-diketones

Zairov

Mustafina

Shamsutdinova

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…This is manifested by the invariance of the lanthanide-centered luminescence of the PSS-coated nanoprecipitated terbium complexes with the cyclophanic 1,3-diketone derivatives which will be further designated as [TbL] (L is cyclophanic 1,3-diketonate) at the pH values varied within wide pH-range (4-9) [ 53 ]. The easy manipulation with the PSS-stabilized colloids through the centrifugation-induced phase separation and further re-dispersion in different solutions enables their re-usability, which, in turn, facilitates their applicability in sensing [ 53 , 61 , 101 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 ].…”

Section: Nanoparticulate Forms Of Cyclophanic 13-diketonate Complmentioning

confidence: 99%

1,3-Diketone Calix[4]arene Derivatives—A New Type of Versatile Ligands for Metal Complexes and Nanoparticles

2021

View full text Add to dashboard Cite

The present review is aimed at highlighting outlooks for cyclophanic 1,3-diketones as a new type of versatile ligands and building blocks of the nanomaterial for sensing and bioimaging. Thus, the main synthetic routes for achieving the structural diversity of cyclophanic 1,3-diketones are discussed. The structural diversity is demonstrated by variation of both cyclophanic backbones (calix[4]arene, calix[4]resorcinarene and thiacalix[4]arene) and embedding of different substituents onto lower or upper macrocyclic rims. The structural features of the cyclophanic 1,3-diketones are correlated with their ability to form lanthanide complexes exhibiting both lanthanide-centered luminescence and magnetic relaxivity parameters convenient for contrast effect in magnetic resonance imaging (MRI). The revealed structure–property relationships and the applicability of facile one-pot transformation of the complexes to hydrophilic nanoparticles demonstrates the advantages of 1,3-diketone calix[4]arene ligands and their complexes in developing of nanomaterials for sensing and bioimaging.

show abstract

“…Being introduced into the bloodstream, nanoparticles adsorb plasma proteins on their surface. These interactions make significant changes in the properties of nanoparticles, such as aggregation state, surface chemistry, and surface charge, which affect their functionality [11].…”

Section: Introductionmentioning

confidence: 99%

The State of Antioxidant Systems and Lipids’ Peroxidation Under the Action of Complex Substances

2022

Nanosistemi, Nanomateriali, Nanotehnologii

View full text Add to dashboard Cite

Nanoparticles based on gadolinium(iii) and europium(iii) complexes for biovisualization

Cited by 13 publications

References 19 publications

High performance magneto-fluorescent nanoparticles assembled from terbium and gadolinium 1,3-diketones

High performance magneto-fluorescent nanoparticles assembled from terbium and gadolinium 1,3-diketones

1,3-Diketone Calix[4]arene Derivatives—A New Type of Versatile Ligands for Metal Complexes and Nanoparticles

The State of Antioxidant Systems and Lipids’ Peroxidation Under the Action of Complex Substances

Contact Info

Product

Resources

About