Nanoparticles decorated with folate based on a site-selective αCD-rotaxanated PEG-<i>b</i>-PCL copolymer for targeted cancer therapy

Poggetto, Giovanni Dal; Troise, Salvatore Simone; Conte, Claudia; Marchetti, Roberta; Moret, Francesca; Iadonisi, Alfonso; Silipo, Alba; Lanzetta, Rosa; Malinconico, Mario; Quaglia, Fabiana; Laurienzo, Paola

doi:10.1039/d0py00158a

Cited by 9 publications

(5 citation statements)

References 51 publications

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“…By refining the reaction domains, formulations with increased binding affinities can be produced, optimizing ligand orientation for maximal interaction and enhancing the effectiveness of the covalent conjugation. [87,88] Nonetheless, strong covalent binding faces limitations arising from the control of environmental conditions during functionalization, such as pH [89] as well as non-specific interactions between living systems and the nanoparticles. [90] The complex nature of wet-chemical covalent conjugation approaches remains their major drawback.…”

Section: Biofunctional Molecules Attached To Polymeric Nanoparticles:...mentioning

confidence: 99%

Surface Bio‐engineered Polymeric Nanoparticles

Haidar,

Bilek,

Akhavan

2024

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Surface bio‐engineering of polymeric nanoparticles (PNPs) has emerged as a cornerstone in contemporary biomedical research, presenting a transformative avenue that can revolutionize diagnostics, therapies, and drug delivery systems. The approach involves integrating bioactive elements on the surfaces of PNPs, aiming to provide them with functionalities to enable precise, targeted, and favorable interactions with biological components within cellular environments. However, the full potential of surface bio‐engineered PNPs in biomedicine is hampered by obstacles, including precise control over surface modifications, stability in biological environments, and lasting targeted interactions with cells or tissues. Concerns like scalability, reproducibility, and long‐term safety also impede translation to clinical practice. In this review, these challenges in the context of recent breakthroughs in developing surface‐biofunctionalized PNPs for various applications, from biosensing and bioimaging to targeted delivery of therapeutics are discussed. Particular attention is given to bonding mechanisms that underlie the attachment of bioactive moieties to PNP surfaces. The stability and efficacy of surface‐bioengineered PNPs are critically reviewed in disease detection, diagnostics, and treatment, both in vitro and in vivo settings. Insights into existing challenges and limitations impeding progress are provided, and a forward‐looking discussion on the field's future is presented. The paper concludes with recommendations to accelerate the clinical translation of surface bio‐engineered PNPs.

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Section: Biofunctional Molecules Attached To Polymeric Nanoparticles:...mentioning

confidence: 99%

Surface Bio‐engineered Polymeric Nanoparticles

Haidar,

Bilek,

Akhavan

2024

Small

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“…For its low toxicity, low immunogenicity, and high affinity to folate receptors (FR) overexpressed in a variety of cancer cells, FA (folic acid) has been widely used as an excellent targeting agent to improve the delivery of anticancer drugs or gene products [ 48 , 49 ]. FA-modified PEG could increase the cell uptake of PR nanoparticles in KB cells [ 50 ]. Additionally, FA introduced to cationic PRs could achieve enhanced efficiency of gene delivery.…”

Section: Cd-based Polyrotaxanesmentioning

confidence: 99%

Cyclodextrin-Based Polymeric Drug Delivery Systems for Cancer Therapy

Liu

Qiu

2023

Polymers

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Cyclodextrins (CDs) are one of the most extensively studied cyclic-oligosaccharides due to their low toxicity, good biodegradability and biocompatibility, facile chemical modification, and unique inclusion capacity. However, problems such as poor pharmacokinetics, plasma membrane disruption, hemolytic effects and a lack of target specificity still exist for their applications as drug carriers. Recently, polymers have been introduced into CDs to combine the advantages of both biomaterials for the superior delivery of anticancer agents in cancer treatment. In this review, we summarize four types of CD-based polymeric carriers for the delivery of chemotherapeutics or gene agents for cancer therapy. These CD-based polymers were classified based on their structural properties. Most of the CD-based polymers were amphiphilic with the introduction of hydrophobic/hydrophilic segments and were able to form nanoassemblies. Anticancer drugs could be included in the cavity of CDs, encapsulated in the nanoparticles or conjugated on the CD-based polymers. In addition, the unique structures of CDs enable the functionalization of targeting agents and stimuli-responsive materials to realize the targeting and precise release of anticancer agents. In summary, CD-based polymers are attractive carriers for anticancer agents.

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“…Hence, PCL copolymers have widely been used in basic and clinical investigations. For instance, PEG-PCL copolymer is a proper biomaterial that has steadily been utilized for therapeutic purposes [28][29][30] . As another example, a blended PCL with polypropylene or polyethylene and spun into fibers develop a notably efficient pigment dispersing aid 31 .…”

Section: Pcl and Combined Polymersmentioning

confidence: 99%

Electrospun Polycaprolactone Nanofibers: Current Research and Applications in Biomedical Application

et al. 2021

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Unique mechanical properties, miscibility potency, and biodegradability are the three prominent features of Polycaprolactone (PCL), making it an attractive biomaterial which commonly applied in regenerative medicine and biomedical engineering. Different strategies developed for fabricating nanofibrous construct, electrospinning is a practical, simple, and efficient technique based on electro-hydrodynamic systems that use an electrified viscous fluid jet drawn by the air toward a collector at a changing electric potential. PCL electrospun-based nanofibrous composites as proper scaffolds are employed in stem cell-related research, particularly in tissue engineering, wound dressing, and systems designed for sending drugs. A compilation of mechanochemical properties and most common biological performance on PCL-based electrospun fibrous structures in biomedical application are included in this study. Therefore, electrospun PCL nanofiber applying has been presented, and after that, current progress and prospects have been discussed. Literature reviews revealed that electrospun PCL nanofibrous composites had gained significant attention in regenerative medicine, and these structures have shown notable development in mechanobiological properties. This evidence is a crucial success for biomedical strategies, especially in regenerative medicine.

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Nanoparticles decorated with folate based on a site-selective αCD-rotaxanated PEG-b-PCL copolymer for targeted cancer therapy

Abstract: NPs fabricated from a mixture of PEG-b-PCL and selectively rotaxanated Fol-PEG(αCD)-PCL showed internalisation in KB cells through an active targeting mechanism.

Cited by 9 publications

References 51 publications

Surface Bio‐engineered Polymeric Nanoparticles

Surface Bio‐engineered Polymeric Nanoparticles

Cyclodextrin-Based Polymeric Drug Delivery Systems for Cancer Therapy

Electrospun Polycaprolactone Nanofibers: Current Research and Applications in Biomedical Application

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