Nanoparticles for Cancer Targeting: Current and Future Directions

Swain, Sanjit Kumar; Sahu, Prafulla Kumar; Beg, Sarwar; Babu, Sitty Manohar

doi:10.2174/1567201813666160713121122

Cited by 148 publications

(98 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are a variety of different nanoparticle types, depending on manufacturing processes and components (Figure 5) [103]. The nanoparticle formula can be designed to produce carriers for oral [104], skin [105], liver [106], pulmonary [107], brain [108], or cancer targeting [109]. Nanoparticles can be used to deliver a combination of biomolecules to enhance the therapeutic effect against disease.…”

Section: Delivery Methodsmentioning

confidence: 99%

Targeting Splicing in the Treatment of Human Disease

Suñé-Pou

Prieto-Sánchez

Boyero-Corral

et al. 2017

Genes

View full text Add to dashboard Cite

The tightly regulated process of precursor messenger RNA (pre-mRNA) alternative splicing (AS) is a key mechanism in the regulation of gene expression. Defects in this regulatory process affect cellular functions and are the cause of many human diseases. Recent advances in our understanding of splicing regulation have led to the development of new tools for manipulating splicing for therapeutic purposes. Several tools, including antisense oligonucleotides and trans-splicing, have been developed to target and alter splicing to correct misregulated gene expression or to modulate transcript isoform levels. At present, deregulated AS is recognized as an important area for therapeutic intervention. Here, we summarize the major hallmarks of the splicing process, the clinical implications that arise from alterations in this process, and the current tools that can be used to deliver, target, and correct deficiencies of this key pre-mRNA processing event.

show abstract

Section: Delivery Methodsmentioning

confidence: 99%

Targeting Splicing in the Treatment of Human Disease

Suñé-Pou

Prieto-Sánchez

Boyero-Corral

et al. 2017

Genes

View full text Add to dashboard Cite

show abstract

“…The major interest in cancer therapy is also reflected in an important industry. Some currently marketed nanotherapeutics in cancer therapy are liposomes, nanoparticles, nanocapsules, nanoemulsions, nanocrystals, and micelles [22][23][24][25][26]. However, nanomedicines currently approved for cancer therapy are mostly liposomes.…”

Section: General Nanoparticlementioning

confidence: 99%

Nanosized Minicells Generated by Lactic Acid Bacteria for Drug Delivery

Nguyen

Jovel

Nguyen

2017

Journal of Nanomaterials

View full text Add to dashboard Cite

Nanotechnology has the ability to target specific areas of the body, controlling the drug release and significantly increasing the bioavailability of active compounds. Organic and inorganic nanoparticles have been developed for drug delivery systems. Many delivery systems are through clinical stages for development and market. Minicell, a nanosized cell generated by bacteria, is a potential particle for drug delivery because of its size, safety, and biodegradability. Minicells produced by bacteria could drive therapeutic agents against cancer, microbial infection, and other diseases by targeting. In addition, minicells generated by lactic acid bacteria being probiotics are more interesting than others because of their benefits like safety, immunological improvement, and biodegradation. This review aims to highlight the stages of development of nanoparticle for drug delivery and discuss their advantages and limitations to clarify minicells as a new opportunity for the development of potential nanoparticle for drug delivery.

show abstract

“…The results of experimental studies suggest, however, that the use of NPs in medicine may revolutionize the therapeutic success of treating many diseases, i.e., neoplastic diseases, heart diseases, but also neurodegenerative diseases or wounds difficult to heal. [7][8][9][10][11] On the other hand, controversies about their long-term toxicity, which is not yet fully known, have also been raised. 12 These concerns are the reason why work is being done to develop the legal regulations regarding nanotechnology methods.…”

Section: Introductionmentioning

confidence: 99%