Nanoparticles for hematologic diseases detection and treatment

Abstract

Nanotechnology, as an interdisciplinary science, combines engineering, physics, material sciences, and chemistry with the biomedicine knowhow, trying the management of a wide range of diseases. Nanoparticle-based devices holding tumor imaging, targeting and therapy capabilities are formerly under study. Since conventional hematological therapies are sometimes defined by reduced selectivity, low therapeutic efficacy and many side effects, in this review we discuss the potential advantages of the NPs’ use in alternative/combined strategies. In the introduction the basic notion of nanomedicine and nanoparticles’ classification are described, while in the main text nanodiagnostics, nanotherapeutics and theranostics solutions coming out from the use of a wide-ranging NPs availability are listed and discussed.

Nanotechnology-based diagnostics and therapeutics in acute lymphoblastic leukemia: a systematic review of preclinical studies

“…6 As a result, finding and developing smart delivery methods that efficiently preserve and distribute therapeutic medications, improve targeting capabilities, and accomplish controlled release are critical to healing leukemia. 2–4,17–19…”

“…6 As a result, nding and developing smart delivery methods that efficiently preserve and distribute therapeutic medications, improve targeting capabilities, and accomplish controlled release are critical to healing leukemia. [2][3][4][17][18][19] Conventional detection methods show some restrictions, such as being costly, laborious, and time-consuming. 20 They require a set of elaborated devices while suffering from low sensitivity and need several processing phases, which makes them unfavourable for easy and fast medical monitoring or analysis.…”

“…Nanotechnologies can encapsulate and distribute hydrophobic compounds that are difficult to freely administrate and enhance their solubility and biocompatibility. 2,19,22 The materials used for nanosystems must be biocompatible, non-toxic, biodegradable, and sufficiently stable for in vivo administration. 2,9,10,12,15,19,23,24 Nanomaterials also become great micro-spectroscopic contrasting agents or labels for imaging, 9,15,19,25,26 which helps in fast, specic, and sensitive diagnostics and is benecial in the discovery of minimal residual diseases (MRDs) aer treatment.…”

Special Issue “Metal and Metal Oxide Nanoparticles: Design, Characterization, and Biomedical Applications”

“…In more detail, when referring to nanomaterials, an increasingly successfully tool of nanotechnologies, nanoparticles are categorized as materials in which at least one dimension is less than 100 nm in diameter. Among the various nanoparticle categories, metal and metal oxide nanoparticles stand out as emerging nanotechnological solutions for a wide range of biological and medical physio/pathological open questions [ 1 , 2 , 3 ]. This Special Issue covers the fundamental science, design, characterization, and biomedical applications of metal and metal oxide nanomaterials and the five papers here presented embrace all the aspects determining the performance of these systems, ranging from their synthesis, design, chemical, physical, and biological functionalization, to their characterization and successful applications.…”

Technologies for Cancer Research

“…In an increasingly personalized medicine scenario, the use of new smart materials and technologies opens up new possibilities for the application of micro/nanoparticles [1,2], lab on chips [3] and a whole series of more or less engineered biological components for drug delivery, diagnosis or treatment in cancer management [4][5][6].…”