Nanoparticles for In Vivo Lifetime Multiplexed Imaging

Ximendes, Erving; Ortgies, Dirk H.; Tan, Meiling; Chen, Guanying; Rosal, Blanca del

doi:10.1007/978-1-0716-1593-5_15

Cited by 1 publication

(1 citation statement)

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“…[43][44][45] The lifetime-based thermometry of LLNs is less prone to the interference of absorption and scattering of biological tissue. [44,46] Nevertheless, the typical instrument for lifetime-based in vivo temperature monitoring is mainly composed of pulse light generation unit for excitation, synchronized optical unit for isolating luminescence decay, and signal detection unit, which brings about more overall technical complexity and cost. Additionally, lifetime imaging typically requires longer acquisition time, [47] which may not be conducive to the application in ischemic stroke, especially in the case of acute and critical stroke (sometimes in an unstable or extremely restless state) where time-saving diagnostic method is more favorable.…”

Section: Introductionmentioning

confidence: 99%

Near Infrared Emissive Lanthanide Luminescence Nanoparticle Used in Early Diagnosis and Brain Temperature Detection for Ischemic Stroke

Li,

Kong

et al. 2023

Adv Healthcare Materials

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Ischemic stroke (IS) is one of the most dangerous diseases resulting in high mortality and morbidity. The increased brain temperature after IS is closely related to prognosis, making it highly significant to the early diagnosis and the progression evaluation of IS. Herein, a temperature‐responsive near infrared (NIR) emissive lanthanide luminescence nanoparticle is developed for the early diagnosis and brain temperature detection of IS. After intravenous injection, the nanoparticles can pass through the damaged blood‐brain barrier of the ischemic region, allowing the extravasation and enrichment of nanoparticles into the ischemic brain tissue. The NIR luminescence signals of the nanoparticles are used not only to judge the location and severity of the cerebral ischemic injury but also to report the brain temperature variation in the ischemic area through a visualized way. The results show that the designed nanoparticles can be used for the early diagnosis of ischemic stroke and minimally invasive temperature detection of cerebral ischemic tissues in transient middle cerebral artery occlusion mice model, which is expected to make the clinical diagnosis of ischemic stroke more rapid and convenient, more accurately evaluate the state of brain injury in stroke patients and also guide stroke hypothermia treatment.This article is protected by copyright. All rights reserved

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