Nanoparticles formed by complexation of poly-gamma-glutamic acid with lead ions

Bodnár, Magdolna; Kjøniksen, Anna–Lena; Molnar, Reka Melinda; Hartmann, John F.; Daróczi, Lajos; Nyström, Bo; Borbély, János

doi:10.1016/j.jhazmat.2007.09.080

Cited by 8 publications

(6 citation statements)

References 25 publications

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“…Glutamate is polymerised inside the cell through the γ-amide linkages. The polymer α-PGA is produced by chemical synthesis, while γ-PGA is produced microbiologically by a number of Bacillus species [27,29,30,31,32]. γ-PGA can be degraded in vivo to glutamic acid residues.…”

Section: Poly-γ-glutamic Acid (γ-Pga) As An Antimicrobial Coating mentioning

confidence: 99%

Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for Antimicrobials and Other Biomedical Applications

Khalil

Burns

Radecka

et al. 2017

IJMS

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In the past decade, poly-γ-glutamic acid (γ-PGA)-based micro/nanoparticles have garnered remarkable attention as antimicrobial agents and for drug delivery, owing to their controlled and sustained-release properties, low toxicity, as well as biocompatibility with tissue and cells. γ-PGA is a naturally occurring biopolymer produced by several gram-positive bacteria that, due to its biodegradable, non-toxic and non-immunogenic properties, has been used successfully in the medical, food and wastewater industries. Moreover, its carboxylic group on the side chains can offer an attachment point to conjugate antimicrobial and various therapeutic agents, or to chemically modify the solubility of the biopolymer. The unique characteristics of γ-PGA have a promising future for medical and pharmaceutical applications. In the present review, the structure, properties and micro/nanoparticle preparation methods of γ-PGA and its derivatives are covered. Also, we have highlighted the impact of micro/nanoencapsulation or immobilisation of antimicrobial agents and various disease-related drugs on biodegradable γ-PGA micro/nanoparticles.

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Section: Poly-γ-glutamic Acid (γ-Pga) As An Antimicrobial Coating mentioning

confidence: 99%

Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for Antimicrobials and Other Biomedical Applications

Khalil

Burns

Radecka

et al. 2017

IJMS

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“…They indicated the strong complexation capacity of PGA for lead ions indicated a promising sorbent for removal of heavy metals in polluted water. 166 Inbaraj and Chen, (2012) demonstrated that the poly (γ-Glutamic acid)-coated super paramagnetic nanoparticles played an important role in the discharge of heavy metals from the simulated gastrointestinal fluid and metal solutions. In this study, through co-precipitation method, edible biopolymer PGA was used to modify Super Paramagnetic Iron Oxide Nanoparticles (SPIONs).…”

Section: Heavy Metal and Radionuclide Binding Agentsmentioning

confidence: 99%

Untitled

2015

IJPSR

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Mankind has been exploring many new dimensions and techniques to obtain the most feasible and cost effective biopolymers. Biopolymers are the 21 st century polymers and are in great demand as they are very easy to produce through the microbial partners and their conglomeration. Future is all about the emancipation of higher finesse quality products with an iota of eco-friendliness. Biodegradation and low pollutant output has made these polymers from the biological sources, a great eco-friendly substituent for the chemical based polymers. Poly--Glutamic Acid (PGA) is a naturally occurring anionic polymer composed of extensively viscous homo-polyamide of D and L-Glutamic acid units. Its multi-functionality, biodegradability, non-toxicity, compatibility and edibility have made it a promising biopolymer for food, cosmetics and pharmaceutical industries. PGA has several applications in environmental, agricultural and biomedical products as well as it can be used as biodegradable packing material and in other applications including conductive display material, drug delivery, gene vector, dispersant and enzyme-immobilizing material. In this review, we have discussed about the history of PGA, its structure, synthesis, genes and its organization and the applications of PGA.

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“…While for Pb(II), the metal ions probably only interacted with carboxylic groups of linear g-PGA chains. 27 Moreover, metal interactions with g-PGA have signicant effects on g-PGA conformation. It has been reported that the metal-g-PGA interactions lead g-PGA to form the helical conformation at higher pH because of metal binding to COO À side-chains, 28 and helix conformation has less functional groups for metal binding than that of the random coil conformation.…”

Section: Metal Binding Studies Of G-pgamentioning

confidence: 99%