Nanoparticles in endothelial theranostics

Zapotoczny, Szczepan; Szczubiałka, Krzysztof; Nowakowska, Maria

doi:10.1016/j.pharep.2015.05.018

Cited by 17 publications

(9 citation statements)

References 73 publications

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“…After intravascular administration, nanoparticles will initially contact the endothelium of the blood vessel, which is composed of a thin continuous layer of cell lining. The interaction of multifunctional nanoparticles with the endothelium is important,38–42 as it is the main target in the treatment of disease, including inflammatory, cardiovascular and oncological diseases 43,44. PEG coating reduces adhesion of polystyrene spheres to endothelial monolayer under physiological shear in vitro 39.…”

Section: Introductionmentioning

confidence: 99%

<p>Effects of PEGylation on capture of dextran-coated magnetic nanoparticles in microcirculation</p>

Chiu¹,

Chung²,

Chen³

et al. 2019

IJN

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Background Magnetic nanoparticles (MNPs) can be localized against hemodynamic forces in blood vessels with the application of an external magnetic field. In addition, PEGylation of nanoparticles may increase the half-life of nanocomposites in circulation. In this work, we examined the effect of PEGylation on the magnetic capture of MNPs in vivo. Methods Laser speckle contrast imaging and capillaroscopy were used to assess the magnetic capture of dextran-coated MNPs and red blood cell (RBC) flow in cremaster microvessels of anesthetized rats. Magnetic capture of MNPs in serum flow was visualized with an in vitro circulating system. The effect of PEGylation on MNP-endothelial cell interaction was studied in cultured cells using an iron assay. Results In microcirculation through cremaster muscle, magnet-induced retention of 250 nm MNPs was associated with a variable reduction in RBC flow, suggesting a dynamic coupling of hemodynamic and magnetic forces. After magnet removal, faster restoration of flow was observed in PEG(+) than PEG(–) group, which may be attributed to a reduced interaction with vascular endothelium. However, PEGylation appears to be required for magnetic capture of 50 nm MNPs in microvessels, which was associated with increased hydrodynamic diameter to 130±6 nm in serum, but independent of the ς-potential. Conclusion These results suggest that PEGylation may enhance magnetic capture of smaller MNPs and dispersion of larger MNPs after magnet removal, which may potentially affect the targeting, pharmacokinetics and therapeutic efficacy.

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Section: Introductionmentioning

confidence: 99%

<p>Effects of PEGylation on capture of dextran-coated magnetic nanoparticles in microcirculation</p>

Chiu¹,

Chung²,

Chen³

et al. 2019

IJN

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“…More recently, the use of molecular imaging with positron emission tomography (PET) has come into use. PET can more efficiently characterize brain tumors by investigating metabolic processes such as receptor binding, DNA synthesis or enzyme activity, oxygen metabolism and blood flow 54 - 57 . It is also observed that in comparison to other ailments, cancer is one of the most multifarious diseases with different phenotypic expressions at various organ sites.…”

Section: Current Approaches V/s Nanotheranostics For Brain Cancermentioning

confidence: 99%

Nanotheranostics: Emerging Strategies for Early Diagnosis and Therapy of Brain Cancer

Sonali¹,

Viswanadh²,

Singh³

et al. 2018

Nanotheranostics

133

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Nanotheranostics have demonstrated the development of advanced platforms that can diagnose brain cancer at early stages, initiate first-line therapy, monitor it, and if needed, rapidly start subsequent treatments. In brain nanotheranostics, therapeutic as well as diagnostic entities are loaded in a single nanoplatform, which can be further developed as a clinical formulation for targeting various modes of brain cancer. In the present review, we concerned about theranostic nanosystems established till now in the research field. These include gold nanoparticles, carbon nanotubes, magnetic nanoparticles, mesoporous silica nanoparticles, quantum dots, polymeric nanoparticles, upconversion nanoparticles, polymeric micelles, solid lipid nanoparticles and dendrimers for the advanced detection and treatment of brain cancer with advanced features. Also, we included the role of three-dimensional models of the BBB and cancer stem cell concept for the advanced characterization of nanotheranostic systems for the unification of diagnosis and treatment of brain cancer. In future, brain nanotheranostics will be able to provide personalized treatment which can make brain cancer even remediable or at least treatable at the primary stages.

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“…Nanotheranostics can be also used for the management of atherosclerosis and its cardiovascular and cerebrovascular manifestations [17][18][19]. As with cancer, it is expected that multimodal nanoparticles will allow for non-invasive detection, long-term monitoring (for example using Fig.…”

Section: Opportunitiesmentioning

confidence: 99%

The Nanopharmacology and Nanotoxicology of Nanomaterials: New Opportunities and Challenges

2016

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Nanoparticles in endothelial theranostics

Abstract: The paper presents the recent advances in the development and studies of multifunctional nanoparticles which can be used to prevent/cure the cardiovascular diseases by detecting, treating and monitoring the early stages of atherosclerotic and thrombotic changes in endothelium.

Cited by 17 publications

References 73 publications

<p>Effects of PEGylation on capture of dextran-coated magnetic nanoparticles in microcirculation</p>

<p>Effects of PEGylation on capture of dextran-coated magnetic nanoparticles in microcirculation</p>

Nanotheranostics: Emerging Strategies for Early Diagnosis and Therapy of Brain Cancer

The Nanopharmacology and Nanotoxicology of Nanomaterials: New Opportunities and Challenges

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