2024
DOI: 10.3389/fimmu.2024.1429335
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Nanoparticles loaded with IL-2 and TGF-β promote transplantation tolerance to alloantigen

David A. Horwitz,
Ju Hua Wang,
Dongin Kim
et al.

Abstract: We have previously reported that nanoparticles (NPs) loaded with IL-2 and TGF-β and targeted to T cells induced polyclonal T regulatory cells (Tregs) that protected mice from graft-versus-host disease (GvHD). Here, we evaluated whether administration of these NPs during alloantigen immunization could prevent allograft rejection by converting immunogenic responses to tolerogenic ones. Using C57BL/6 mice and BALB/c mice as either donors or recipients of allogeneic splenocytes, we found that treatment with the to… Show more

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