Nanoparticles with Curcumin and Piperine Modulate Steroid Biosynthesis in Prostate Cancer
Jibira Yakubu,
Evangelos Natsaridis,
Therina du Toit
et al.
Abstract:Endogenous androgens are pivotal in the development and progression of prostate cancer (PC). We investigated nanoparticle formulations of curcumin and piperine in modulating steroidogenesis within PC cells. Using multiple PC cell lines (LNCaP, VCaP, DU145 and PC3) we studied the effects of curcumin, piperine, and their nanoparticle formulations—curcumin nanoparticles, piperine nanoparticles, and curcumin-piperine nanoparticles (CPN)—on cell viability, migration, and steroid biosynthesis. Curcumin and its nanop… Show more
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