Nanoparticulate Systems for Bioactive Agent Delivery: What Is the Missing Link in Research for Real Applications?

Abstract

Diverse nanoparticulate systems, ranging from polymeric nanoparticles to liposomes, have been exploited as carriers of bioactive agents in recent years; however, the use of these systems has been confined largely to the laboratory context till now. Systems that can successfully be adopted for bioactive agent delivery in practice are few. Herein, such low efficiency in clinical translation is partly due to the lack of awareness of the similar nature between a carrier and a real drug. To rectify this situation, it is important to treat a carrier as an ordinary drug despite its absence of therapeutic effects. The current situation in prevalent bioactive agent delivery research, as well as those routine research practices that should be changed to enhance clinical translation, will be discussed here.

Metalated covalent organic frameworks: from synthetic strategies to diverse applications

“…With the joint efforts of researchers in chemistry, materials science, cell biology, and clinical medicine, the application of nanomaterials in tumor therapeutics, 783–785 antibacterial therapy, 786,787 and tissue engineering 788 has made great progress over the past three decades.…”