Nanoporous metal organic frameworks as hybrid polymer–metal composites for drug delivery and biomedical applications

Beg, Sarwar; Rahman, Mahfoozur; Jain, Atul; Saini, Sumant; Midoux, Patrick; Pichon, Chantal; Ahmad, Feroz; Akhter, Sohail

doi:10.1016/j.drudis.2016.10.001

Cited by 239 publications

(108 citation statements)

References 91 publications

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“…For example, hydro/solvothermal synthesis is a typical method to prepare MOFs using high temperature and high pressure in polar solvents, which impart the material with advantages of easy preparation of crystals, simple and convenient synthetic approach. However, it usually takes a long reaction time, and requires organic solvents and harsh conditions like high temperature and high pressure, rendering it unfavorable to scale‐up production 9. Microwave‐assisted synthesis is beneficial for the preparation of MOFs with homogeneous size distribution in a short reaction time due to rapid nucleation process.…”

Section: Synthesis and Functionalization Of Mofsmentioning

confidence: 99%

Metal–Organic Frameworks for Biomedical Applications

Yang

2020

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Metal–organic frameworks (MOFs) are an interesting and useful class of coordination polymers, constructed from metal ion/cluster nodes and functional organic ligands through coordination bonds, and have attracted extensive research interest during the past decades. Due to the unique features of diverse compositions, facile synthesis, easy surface functionalization, high surface areas, adjustable porosity, and tunable biocompatibility, MOFs have been widely used in hydrogen/methane storage, catalysis, biological imaging and sensing, drug delivery, desalination, gas separation, magnetic and electronic devices, nonlinear optics, water vapor capture, etc. Notably, with the rapid development of synthetic methods and surface functionalization strategies, smart MOF‐based nanocomposites with advanced bio‐related properties have been designed and fabricated to meet the growing demands of MOF materials for biomedical applications. This work outlines the synthesis and functionalization and the recent advances of MOFs in biomedical fields, including cargo (drugs, nucleic acids, proteins, and dyes) delivery for cancer therapy, bioimaging, antimicrobial, biosensing, and biocatalysis. The prospects and challenges in the field of MOF‐based biomedical materials are also discussed.

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Section: Synthesis and Functionalization Of Mofsmentioning

confidence: 99%

Metal–Organic Frameworks for Biomedical Applications

Yang

2020

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637

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“…Metal–organic frameworks (MOFs) is a kind of porous crystals with periodic multi‐dimensional network structure formed by coordination of metal ions and organic ligands, and it's the advance product of nanotechnology . Their considerable applications in gas storage, chemical sensing, medical imaging and catalysis can be attributed to their large specific surface area, biocidal efficiency and thermal‐optical stabilities. Furthermore, those merits give them great application potential in the environment.…”

Section: Introductionmentioning

confidence: 99%

Growth Inhibition of Microcystis aeruginosa by Copper‐based MOFs: Performance and Physiological Effect on Algal Cells

Fan

Zheng

Chen

2018

Applied Organom Chemis

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The problem of cyanobacteria bloom occurring in the eutrophic water increases more serious and urgent needs to be solved. Based on the advantages of Metal-organic frameworks (MOFs), some reported studies have evaluated the inhibition effect of MOFs on algae. However, the influence of that on the physiological characteristics of algal cells has not been investigated thoroughly.In this study, Cu-MOF-74 was successfully synthesized by a facile hydrothermal method and was characterized by XRD and SEM. The growth inhibition of Microcystis aeruginosa were conducted to explore the effects of Cu-MOF-74 based on the physiology of algal cells to reveal algae inhibition mechanism. The results showed that the synthesized Cu-MOF-74 was a large needle-shaped crystal, and the size of the grain was 3-4.5 μm. 1 mg/L of Cu-MOF-74 has relatively excellent inhibitory effect on algae, which can achieve the removal efficiency of 75.5% within 120 hr. Besides, the content of chlorophyll a decreased by about 56%, the diminishing of chlorophyll a and phycobiliprotein concentration resulted in photosystem damage. In this process, ROS accumulated continually in algal cells with the slow release of metal ions Cu 2+ of Cu-MOF-74 which acts as a 'reservoir', then causing the oxidation loss, the reduction of SOD activity and the increase of CAT activity. The hydroxyl radical generated by Cu-MOF-74 caused lipid peroxidation. Thereby the situation above eventually resulted in the death of Microcystis aeruginosa and the concentration of extracellular organic matter increased. All the above, we think Cu-MOF-74 can inhibit the growth of algal cells through effecting on physiology and can be applied to control the cyanobacteria blooms.

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“…In the past few years, numerous studies have demonstrated the great potential of nanoMOFs at the preclinical level for biomedical applications. Many of them were reported very recently based on their bioactive composition, anticancer application, or from a general drug delivery/theranostic perspective . In this review, we aim at providing a global view of the studies that evaluated MOFs' biomedical applications at the preclinical stage, when in vivo tests are described either for pharmacological applications or for toxicity evaluation ( Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

et al. 2018

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In the past few years, numerous studies have demonstrated the great potential of nano particles of metal-organic frameworks (nanoMOFs) at the preclinical level for biomedical applications. Many of them were reported very recently based on their bioactive composition, anticancer application, or from a general drug delivery/theranostic perspective. In this review, the authors aim at providing a global view of the studies that evaluated MOFs' biomedical applications at the preclinical stage, when in vivo tests are described either for pharmacological applications or for toxicity evaluation. The authors first describe the current surface engineering approaches that are crucial to understand the in vivo behavior of the nanoMOFs. Finally, after a detailed and comprehensive analysis of the in vivo studies reported with MOFs so far, and considering the general evolution of the drug delivery science, the authors suggest new directions for future research in the use of nanoMOFs for biomedical applications.

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Nanoporous metal organic frameworks as hybrid polymer–metal composites for drug delivery and biomedical applications

Cited by 239 publications

References 91 publications

Metal–Organic Frameworks for Biomedical Applications

Metal–Organic Frameworks for Biomedical Applications

Growth Inhibition of Microcystis aeruginosa by Copper‐based MOFs: Performance and Physiological Effect on Algal Cells

Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

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