Nanoprecipitation: Applications for Entrapping Active Molecules of Interest in Pharmaceutics

Abstract

Nanoprecipitation technique, also named solvent injection, spontaneous emulsification, solvent displacement, solvent diffusion, interfacial deposition, mixinginduced nanoprecipitation, or flash nanoprecipitation, is recognized as a useful and versatile strategy for trapping active molecules on the submicron and nanoscale levels. Thus, these particles could be intended among others, for developing innovative pharmaceutical products bearing advantages as controlled drug release, target therapeutic performance, or improved stability and organoleptic properties. On this basis, this chapter offers readers a comprehensive revision of the state of the art in research on carriers to be used for pharmaceutical applications and developed by the nanoprecipitation method. In this sense, the starting materials, the particle characteristics, and the in vitro and in vivo performances of the most representative of these carriers, i.e., polymer, lipid, and hybrid particles have been analyzed in a comparative way searching for a general view of the obtained behaviors.

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

“…Some examples are nanoprecipitation, direct injection, emulsion phase transfer, and microfluidics. In solvent displacement methods, the amphiphilic copolymer is dissolved in a water-miscible solvent, added dropwise into water under vigorous stirring, and, finally, the organic phase is removed by dialysis, freeze-drying, or evaporation [ 19 , 153 ]. The existing assembly methodologies can be adapted to encapsulate specific cargoes into polymersomes.…”

Topological defects in polycrystalline hexosomes from β-cyclodextrin fatty esters

“…When saturation is exceeded, the molecules self-assemble, forming nuclei that can grow into well-formed mesophases. 70 However, the resulting particles are expected to adopt a shape that would minimize their surface-to-volume ratio to some extent, 71,72 although there might be a competition with a favorable growth along specific directions of the self-assembled mesophase. This tendency has previously been observed with βCD-C 8 and βCD-C 10 with TDS around 7, that self-assembled into individual barrel-like hexosomes elongated along the column axis.…”

Recent Trends in the Preparation of Nano-Starch Particles

“…Because of their tiny particle sizes and high loading capacities, QSNPs were more successful in protecting and prolonging quercetin bioactivity. Nanoparticles are spontaneously formed when the organic phase is dropped or added in a one-shot manner to the aqueous phase [ 20 ]. The benefits include more homogenous nano-metric particles and reduced usage of hazardous solvents.…”