Nanoproteomics deciphers the prognostic value of EGFR family proteins-based liquid biopsy

Zhang, Yuanyuan; Zhu, Mingchen; Zhu, Jianhua; Xu, Feifei; Chen, Yun

doi:10.1016/j.ab.2023.115133

Cited by 1 publication

(1 citation statement)

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“…Thus, nanoproteomics-based approaches allow for the integration of both nanotechnology and proteomics to capture and enrich low-abundance tumor-associated proteins from human serum or other body fluids as well, using NPs with functionalized surface combined with the analysis of proteoforms by mass spectrometry (MS) [82]. developed a nanoproteomics approach, designing a novel aptamer-modified nano-sized metallic-organic framework (NMOFs-Apt)-based nanomaterial for serum epidermal growth factor receptor (EGFR) family proteins enrichment and the quantitative analysis of both HER2 and EGFR/HER1, using liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based targeted proteomics [83].…”

Section: Nano-"magic Bullets" In Bc Theranosticsmentioning

confidence: 99%

A Nanorobotics-Based Approach of Breast Cancer in the Nanotechnology Era

Neagu,

Jayaweera,

Weraduwage

et al. 2024

IJMS

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We are living in an era of advanced nanoscience and nanotechnology. Numerous nanomaterials, culminating in nanorobots, have demonstrated ingenious applications in biomedicine, including breast cancer (BC) nano-theranostics. To solve the complicated problem of BC heterogeneity, non-targeted drug distribution, invasive diagnostics or surgery, resistance to classic onco-therapies and real-time monitoring of tumors, nanorobots are designed to perform multiple tasks at a small scale, even at the organelles or molecular level. Over the last few years, most nanorobots have been bioengineered as biomimetic and biocompatible nano(bio)structures, resembling different organisms and cells, such as urchin, spider, octopus, fish, spermatozoon, flagellar bacterium or helicoidal cyanobacterium. In this review, readers will be able to deepen their knowledge of the structure, behavior and role of several types of nanorobots, among other nanomaterials, in BC theranostics. We summarized here the characteristics of many functionalized nanodevices designed to counteract the main neoplastic hallmark features of BC, from sustaining proliferation and evading anti-growth signaling and resisting programmed cell death to inducing angiogenesis, activating invasion and metastasis, preventing genomic instability, avoiding immune destruction and deregulating autophagy. Most of these nanorobots function as targeted and self-propelled smart nano-carriers or nano-drug delivery systems (nano-DDSs), enhancing the efficiency and safety of chemo-, radio- or photodynamic therapy, or the current imagistic techniques used in BC diagnosis. Most of these nanorobots have been tested in vitro, using various BC cell lines, as well as in vivo, mainly based on mice models. We are still waiting for nanorobots that are low-cost, as well as for a wider transition of these favorable effects from laboratory to clinical practice.

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Section: Nano-"magic Bullets" In Bc Theranosticsmentioning

confidence: 99%