Nanoscale covalent organic framework for the low-temperature treatment of tumor growth and lung metastasis

A biodegradable covalent organic framework for synergistic tumor therapy

“…As we know, one of the most common NCOF-based tumor treatments is drug delivery. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] The strong host-guest interactions between COF carriers and loaded organic drug molecules might sometimes cause difficulty for payload release under physiological conditions within a limited period, which has oen been observed in COF-based drug delivery systems. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Large aggregates are formed in a synchronous pathway aer exfoliation around the drug-loaded COF crystals, which might limit drug release.…”

“…[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] The strong host-guest interactions between COF carriers and loaded organic drug molecules might sometimes cause difficulty for payload release under physiological conditions within a limited period, which has oen been observed in COF-based drug delivery systems. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Large aggregates are formed in a synchronous pathway aer exfoliation around the drug-loaded COF crystals, which might limit drug release. 25 However, all these time-limited applications require the elimination of the articial NCOFs aer use to restore the surrounding living medium to that of a normal organism.…”

Metalated covalent organic frameworks: from synthetic strategies to diverse applications

“…179 To date, COFs have been validated in the laboratory stage for drug delivery, 809–818 phototherapy, 819–825 immunotherapy, 151,741,826–828 and combination therapy applications. 817,829–832 In particular, the antitumor application of metalated COFs has been a promising research topic in COF-based nanomedicine. The types and contents of metal elements in metalated COFs can be adjusted as needed, which is advantageous for minimizing the potential long-term toxicity of metal elements.…”

Applications of Covalent Organic Frameworks (COFs) in Oncotherapy

“…It is the first example of using enhanced light therapy to suppress primary and metastatic tumors at low temperatures. The approach can be further applied to other therapies involving hypothermia and broaden the development of NCOF-based multifunctional nanomedicines for safe and effective clinical applications [40].…”

“…. Copyright 2021, Royal Society of Chemistry; and (c) Synthesis process of GA@PCOF@PDA nanocomposite; Therapeutic principle of multifunctional COFs-based nanocomposites for low-temperature synergistic oncotherapy[40]. Reproduced with permission from ref [40]…”