Nanoscale surface analysis that combines scanning probe microscopy and mass spectrometry: A critical review

Liang, Zhou; Yin, Zhibin; Yang, Haijun; Xiao, Yuanfang; Li, Jianfeng

doi:10.1016/j.trac.2015.07.009

Cited by 26 publications

(23 citation statements)

References 169 publications

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“…For MS, ions can be created directly by LDI, immediately post-ionized, or collected and analyzed [35]. In an early report of near-field laser MS, direct LDI was achieved by aperture near-field LDI in vacuum [112].…”

Section: Near-field Laser Ablationmentioning

confidence: 99%

“…Early developments in high-spatial resolution laser microprobe MS that are now being adapted to laser ablation biomolecule MSI are discussed as well as below-the-diffraction-limit methods using near-field laser ablation [35] and laser microscope mode [36, 37] MSI. Laser ablation coupled with inductively coupled plasma mass spectrometry (ICP-MS) for bioimaging have been discussed in recent reviews [38-40] and will not be covered here.…”

Section: Introductionmentioning

confidence: 99%

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High resolution laser mass spectrometry bioimaging

Murray

Seneviratne

Ghorai

2016

Methods

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MSI (MSI) was introduced more than five decades ago with secondary ion mass spectrometry (SIMS) and a decade later with laser desorption/ionization (LDI) mass spectrometry (MS). Large biomolecule imaging by matrix-assisted laser desorption/ionization (MALDI) was developed in the 1990s and ambient laser MS a decade ago. Although SIMS has been capable of imaging with a moderate mass range at sub-micrometer lateral resolution from its inception, laser MS requires additional effort to achieve a lateral resolution of 10 μm or below which is required to image at the size scale of single mammalian cells. This review covers untargeted large biomolecule MSI using lasers for desorption/ionization or laser desorption and post-ionization. These methods include laser microprobe (LDI) MSI, MALDI MSI, laser ambient and atmospheric pressure MSI, and near-field laser ablation MS. Novel approaches to improving lateral resolution are discussed, including oversampling, beam shaping, transmission geometry, reflective and through-hole objectives, microscope mode, and near-field optics.

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Section: Near-field Laser Ablationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High resolution laser mass spectrometry bioimaging

Murray

Seneviratne

Ghorai

2016

Methods

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“…In the past decade alone, there has been an explosive growth in instrumentation, handling of data and statistical methodologies. Today, many investigations on food composition are carried out either with mass spectrometry (MS) or nuclear magnetic resonance (NMR) spectrometry coupled to a variety of liquid (LC), gas (GC), and solid-phase extraction (SPE) techniques, e.g., LC-NMR, LC-SPE-NMR, LC-MS, GC-MS and GC-SPE-MS. 4 LC-NMR has been extensively used in wide array of pharmaceutical applications related to natural product identification, biosynthesis and metabolic studies. Recently, Hiller et al discussed the application of online LC-NMR for polymer analysis.…”

Section: Introductionmentioning

confidence: 99%

Recent applications of NMR in food and dietary studies

Ramakrishnan

Luthria

2016

J Sci Food Agric

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Over the last decade, a wide variety of new foods have been introduced into the global marketplace, many with health benefits that exceed those of traditional foods. Simultaneously, a wide range of analytical technologies has evolved that allow greater capability for the determination of food composition. Nuclear magnetic resonance (NMR), traditionally a research tool used for structural elucidation, is now being used frequently for metabolomics and chemical fingerprinting. Its stability and inherent ease of quantification have been exploited extensively to identify and quantify bioactive components in foods and dietary supplements. In addition, NMR fingerprints have been used to differentiate cultivars, evaluate sensory properties of food and investigate the influence of growing conditions on food crops. Here we review the latest applications of NMR in food analysis. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

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“…The best-achieved resolutions were found in the range of a few micrometers (2 -3 μm) [7][8]. Guided through an etched optical fiber (NF-LA aperture configuration) [6,9] or illuminating the extremity of a sharp, pointed tip (NF-LA apertureless configuration) [5,10], the laser field can be locally confined on a very small interaction spot comparable with the fiber/tip radius, i.e., from a few tens to a few hundreds of nanometers. Both the etched optical fiber and the sharp pointed tip are maintained a few nanometers above the sample surface.…”

Section: Introductionmentioning

confidence: 99%