Nanoscale zeolitic imidazolate framework–8 encapsulates crude extract of Ajuga bracteosa wall ex. Benth and enhanced their antibacterial efficiency

Ahanger, Ab Majeed; Kumar, Suresh; Kain, Dolly; Arya, Atul; Vandana, .

doi:10.1016/j.inoche.2021.108940

Cited by 7 publications

(2 citation statements)

References 37 publications

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“…Encapsulated ZIF-8 nanocomposites are frequently used in antibacterial studies. Ahanger et al , and showed the encapsulation of crude extracts of Ajuga bracteosa and Ajuga parviflora species along with enhanced antibacterial efficiency. Our study was based on a comparative analysis of the traditional use of D.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles Using Drymaria cordata and Their Biocompatibility with Hemoglobin: A Therapeutic Potential Approach

Arya,

Chahar,

Bhakuni

et al. 2024

ACS Appl. Bio Mater.

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In this study, we present the synthesis and characterization of AgNPs using Drymaria cordata along with an assessment of their antioxidant, antibacterial, and antidiabetic activities. Antibacterial activities using four bacterial strains, free radical scavenging assays (DPPH and ABTS), and carbohydrate hydrolyzing enzyme inhibition assays were done to examine the therapeutic efficacy of AgNPs. Additionally, herein, we also evaluated the biocompatibility of the AgNPs using hemoglobin (Hb) as a model protein. A comprehensive analysis of Hb and AgNP interactions was carried out by using various spectroscopic, imaging, and size determination studies. Spectroscopic results showed that the secondary structure of Hb was not altered after its interaction with AgNPs. Furthermore, the thermal stability was also well maintained at different concentrations of nanoparticles. This study demonstrated a low-cost, quick, and eco-friendly method for developing AgNPs using D. cordata, and the biocompatible nature of AgNPs was also established. D. cordata-mediated AgNPs have potential applications against bacteria and diabetes and may be utilized for targeted drug delivery.

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Section: Introductionmentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles Using Drymaria cordata and Their Biocompatibility with Hemoglobin: A Therapeutic Potential Approach

Arya,

Chahar,

Bhakuni

et al. 2024

ACS Appl. Bio Mater.

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“…[ 9 ] For the first time, A. bracteosa extract was encapsulated into ZIF‐8, forming a conjugated ABE@ZIF‐8 that shows excellent antibacterial action against Bacillus subtilis and Pseudomonas aeruginous . [ 10 ] A. bracteosa revealed remarkable antileishmanial activity and antiproliferative activity against the Hep‐G2 hepatoma cancer cell line [ 11 ] and showed antimutagenic properties against mouse cells. This animal model confirms that A. braceosa is a rich source of anticancer and antimutagenic properties.…”

Section: Introductionmentioning

confidence: 99%

Telescopic synthesis and encapsulation of anticancer drugs from Ajuga bracteosa Wall. ex Benth. with zeolitic imidazole framework‐8

Ahanger¹,

Kumar²

2022

Applied Organom Chemis

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Cancer is one of the world's fastest-emerging noncommunicable diseases and one of the major causes of death. Zeolitic imidazolate framework-8 (ZIF-8) is a subclass of metal-organic frameworks made up of organic linkers and inorganic nodes. Responsive nanocarriers with biocompatibility and precise drug release ability, superior stability under physiological conditions, pH responsiveness, and tunable drug release properties have emerged as prospective properties of ZIF-8. Among the different options proposed for cancer treatment, natural products are used to find novel hits, which emerge as one of the most successful methods with no adverse effects. Here, we developed a novel nanoscale ZIF-8 core encapsulated drugs extracted from Ajuga bracteosa extract in its frameworks through a facile and efficient strategy. ZIF-8@ABE NPs show a sixfold improvement in instability compared with that of free ABE. It can internalize the NPs into cells and present targeted effects of inhibition of growth on the human Caucasian lung carcinoma cell line (A549) (adenocarcinoma). The sustained release behavior of ZIF-8@ABE has shown a higher efficacy than the free ABE. We envisage that such a biocompatible and biodegradable delivery system may promote the development and translation of hybrid superstructures into smart and personalized delivery platforms, but the limitations imposed by limited loading capacities have stymied the development of innovative multifunctional drug delivery systems.

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Influence of the Conductivity of Polymer Matrix on the Photocatalytic Activity of PAN–PANI–ZIF8 Electrospun Fiber Membranes

et al. 2023

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Nanoscale zeolitic imidazolate framework–8 encapsulates crude extract of Ajuga bracteosa wall ex. Benth and enhanced their antibacterial efficiency

Cited by 7 publications

References 37 publications

Green Synthesis of Silver Nanoparticles Using Drymaria cordata and Their Biocompatibility with Hemoglobin: A Therapeutic Potential Approach

Green Synthesis of Silver Nanoparticles Using Drymaria cordata and Their Biocompatibility with Hemoglobin: A Therapeutic Potential Approach

Telescopic synthesis and encapsulation of anticancer drugs from Ajuga bracteosa Wall. ex Benth. with zeolitic imidazole framework‐8

Influence of the Conductivity of Polymer Matrix on the Photocatalytic Activity of PAN–PANI–ZIF8 Electrospun Fiber Membranes

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