Nanosized selenium and Loranthus micranthus leaves ameliorate streptozotocin-induced hepato-renal dysfunction in rats via enhancement of antioxidant system, regulation of caspase 3 and Nrf2 protein expression

Selenium nanoparticles and metformin ameliorate streptozotocin-instigated brain oxidative-inflammatory stress and neurobehavioral alterations in rats

“…The nanoparticle was produced, lyophilized, and characterized by following the methods in our earlier reports (Ebokaiwe et al 2019(Ebokaiwe et al , 2020a.…”

“…Selected doses of SeNPs and M were chosen based on our earlier studies (Ebokaiwe et al 2019(Ebokaiwe et al , 2020a. Animals were monitored all through the 6-week intervention period for non-fasting blood glucose levels and body weight.…”

“…The emerging influence of nanotechnology as well as reported biological activities of nano-sized materials by ameliorating several metabolic disorders (Al-Quraishy et al 2015;Abdulmalek and Balbaa 2019;Ebokaiwe et al 2019Ebokaiwe et al , 2020a prompted the current study on SeNPs. Also, recent developments in nanotechnological advancement have resulted in the nano-sizing of dietary trace elements with proven biological significance such as Se nanoparticles (SeNPs).…”

“…Also, recent developments in nanotechnological advancement have resulted in the nano-sizing of dietary trace elements with proven biological significance such as Se nanoparticles (SeNPs). These have garnered recognition in the management of metabolic disorders owing to their functions as composites of some enzymes and proteins in the biological system (Rayman and Stranges 2013;Abdulmalek and Balbaa 2019;Ebokaiwe et al 2019Ebokaiwe et al , 2020a.…”

Loranthus micranthusnanoparticles abates streptozotocin‐instigated testicular dysfunction in Wistar rats: Involvement of glucose metabolism enzymes, oxido‐inflammatory stress, steroidogenic enzymes/protein and Nrf2 pathway

“…Leaves of Loranthus micranthus were obtained from the grassland surroundings of AE-FUNAI, Nigeria and authenticated at the herbarium of Department of Botany, University of Ibadan (voucher specimen no: UIH-22812). Protocol for nano-particle production was in accordance with previous report (Ebokaiwe et al, 2019;Griffin et al, 2018;Sarfraz et al, 2018), tersely described as follows; 1% of Plantacare ® 2000 UP was employed for particle stabilisation matching 1% suspension of Loranthus micranthus leaves extract, dissolved in water (distilled water). Magnetic stirring was used to disperse plant materials into the surfactant solution to form coarse suspension.…”