Nanosponges: A Review

Bhowmik, H.; Dhandapani, Nagasamy Venkatesh; Kuila, Anuttam; Kumar, Kammari Harish

doi:10.22159/ijap.2018v10i4.25026

Cited by 55 publications

(38 citation statements)

References 9 publications

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“…Nanosponges are non-irritant, non-toxic, non-mutagenic and non-allergenic agents made-up of a polyester mixed with crosslinkers in a solution. The polyester is biodegradable and effective in delivering the drug to the targeted site ( Pawar et al., 2016 ; Bhowmik et al., 2018 ). Nanosponges come in different forms including cyclodextrin which is most widely used and promising in encapsulation of phytochemicals.…”

Section: Innovative Technology For Mycotoxin Detoxificationmentioning

confidence: 99%

The use of plant extracts and their phytochemicals for control of toxigenic fungi and mycotoxins

Makhuvele

Naidu

Gbashi

et al. 2020

Heliyon

104

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Mycotoxins present a great concern to food safety and security due to their adverse health and socio-economic impacts. The necessity to formulate novel strategies that can mitigate the economic and health effects associated with mycotoxin contamination of food and feed commodities without any impact on public health, quality and nutritional value of food and feed, economy and trade industry become imperative. Various strategies have been adopted to mitigate mycotoxin contamination but often fall short of the required efficacy. One of the promising approaches is the use of bioactive plant components/metabolites synergistically with mycotoxin-absorbing components in order to limit exposure to these toxins and associated negative health effects. In particular, is the fabrication of β-cyclodextrin-based nanosponges encapsulated with bioactive compounds of plant origin to inhibit toxigenic fungi and decontaminate mycotoxins in food and feed without leaving any health and environmental hazard to the consumers. The present paper reviews the use of botanicals extracts and their phytochemicals coupled with β-cyclodextrin-based nanosponge technology to inhibit toxigenic fungal invasion and detoxify mycotoxins.

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Section: Innovative Technology For Mycotoxin Detoxificationmentioning

confidence: 99%

The use of plant extracts and their phytochemicals for control of toxigenic fungi and mycotoxins

Makhuvele

Naidu

Gbashi

et al. 2020

Heliyon

104

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“…To preserve native structure during dispensation and long-term storage is the major drawback in protein formulation and development. In the NSs-based approach proteins like BSA are engulfed in swellable cyclodextrinbased poly(amid amine) NSs to raise the stability of proteins [76].…”

Section: For Protein Reliefmentioning

confidence: 99%

The NANOSPONGES: AN INNOVATIVE DRUG DELIVERY SYSTEM

Kaur¹,

Kumar²

2019

Asian J Pharm Clin Res

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For prolonged time there is a delusion for efficacious targeted drug delivery system, but the chemistry hold complex form had made situations thorny, but the development of new colloidal carrier called nanosponges (NSs) likely circumvent these problems. NSs are the nanoporous particles that can entangle a huge range of material and then be engulfed into a suitable formulation depend on the route of administration. They prevent the drug-protein degradation, lengthen the drug release in a controlled manner, and release the medicament to the target site. They can travel around the body and attach on the surface and liberate the drug in a controlled and predictable manner at the specific target site. They are fine aqueous solubility which makes them a bearer for low water-soluble drugs. Drugs having low bioavailability are best suited for this type of carrier system. Both lipophilic and hydrophilic drugs can be included in NSs. Particle size can change from smaller to bigger by varying the amount of crosslinker to the polymer. Various applications of NSs such as recovering bioavailability of active ingredient molecule and delivery of active ingredient into oral, topical, parenteral, and nasal route make them a superior candidate for targeted delivery of drugs. It can be used as a shipper for biocatalysts in the transport and release of enzymes, proteins, vaccines, and antibodies. They can be prepared by different methods such as emulsion solvent diffusion method, melt method, ultrasound-assisted method, Quasi emulsion solvent diffusion method. This analysis is focusing on the advantages, formulation, evaluation, application, and patent report of the NSs.

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“…Here, the polyester is commonly biodegradable, so it breaks down in the body decently. When the scaffold of nanospongesbreaks down, it discharges the medication particles which are stacked, in an injurious fashion [13].…”

Section: Introductionmentioning

confidence: 99%

Design, Development and Evaluation of Diltiazem Hydrochloride Loaded Nanosponges for Oral Delivery

RAO¹,

REDDY²,

FATHIMA³

et al. 2020

Int J Curr Pharm Sci

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Objective: In the current investigation,nanosponges were set up by emulsion solvent diffusion technique utilizing ethyl cellulose and β-cyclodextrin as polymers. Methods: Diltiazem hydrochloride is taken as model medication for considering different nanosponge formulations. The similarity of different formulation segments was set up by Fourier Transform Infra-Red (FTIR) spectroscopy. Molecular size, surface morphology, entrapment efficiency and drug content of nanosponges were analyzed. Shape and surface morphology of the nanosponges were inspected utilizing scanning electron microscopy. Results: Molecule size of formulated nanosponges was seen in the scope of 186 to 476 nm. Scanning electron microscopy uncovered the permeable, round nature of the nanosponges. The drug content of nanosponges for ethyl cellulose containing formulations was seen as in the scope of 62.25 to 85.11% and for the β-cyclodextrin containing details were seen as in the scope of 65.18-89.67%. The percentage entrapment effectiveness of nanosponges for ethyl cellulose containing formulations were seen as in the scope of 54.18 to 79.49% and for the β-cyclodextrin containing details were seen as in the scope of 58.21-83.45%. In vitro drugreleasefindings demonstrated that at 12 h ethyl cellulose containing formulations discharged the drug in the scope of 57.27-89.09% and for the β-cyclodextrin containing formulations discharged in the scope of 73.94-93.26%. Conclusion: Sustained drugreleasefrom formulations is supported if there is an occurrence of ethyl cellulose in the formulations rather with plans containing β-cyclodextrin.

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Nanosponges: A Review

Cited by 55 publications

References 9 publications

The use of plant extracts and their phytochemicals for control of toxigenic fungi and mycotoxins

The use of plant extracts and their phytochemicals for control of toxigenic fungi and mycotoxins

The NANOSPONGES: AN INNOVATIVE DRUG DELIVERY SYSTEM

Design, Development and Evaluation of Diltiazem Hydrochloride Loaded Nanosponges for Oral Delivery

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