Nanostructure system: Liposome – A bioactive carrier in drug delivery systems

Minocha, Neha; Kumar, Virender

doi:10.1016/j.matpr.2022.09.494

Cited by 9 publications

(4 citation statements)

References 28 publications

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“…Liposomes can be classified as unilamellar vesicles (UV) with a single phospholipid bilayer membrane or multilamellar vesicles (MLV) with several bilayer membranes resembling an onion-like structure. ULVs can be further classified as small unilamellar vesicles (SUV, diameter of 20–100 nm), large unilamellar vesicles (LUV, diameter 100 nm–1 µm), giant unilamellar vesicles (GUV diameter > 1 µm, [ 24 ], and multivesicular vesicles (MVV, 1.6–10.5 µm) that demonstrate a honeycomb-like structure with multiple vesicles embedded in a single lipid bilayer structure [ 47 , 54 , 55 , 56 ]. Liposomes ranging between 50 and 450 nm 3 in volume are used for medical applications.…”

Section: Liposomal-based Smart Drug Deliverymentioning

confidence: 99%

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Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes

2023

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To improve currently available cancer treatments, nanomaterials are employed as smart drug delivery vehicles that can be engineered to locally target cancer cells and respond to stimuli. Nanocarriers can entrap chemotherapeutic drugs and deliver them to the diseased site, reducing the side effects associated with the systemic administration of conventional anticancer drugs. Upon accumulation in the tumor cells, the nanocarriers need to be potentiated to release their therapeutic cargo. Stimulation can be through endogenous or exogenous modalities, such as temperature, electromagnetic irradiation, ultrasound (US), pH, or enzymes. This review discusses the acoustic stimulation of different sonosensitive liposomal formulations. Emulsion liposomes, or eLiposomes, are liposomes encapsulating phase-changing nanoemulsion droplets, which promote acoustic droplet vaporization (ADV) upon sonication. This gives eLiposomes the advantage of delivering the encapsulated drug at low intensities and short exposure times relative to liposomes. Other formulations integrating microbubbles and nanobubbles are also discussed.

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Section: Liposomal-based Smart Drug Deliverymentioning

confidence: 99%

“…Liposomes ranging between 50 and 450 nm 3 in volume are used for medical applications. SUVs are most commonly used in drug-delivery applications due to their uniform encapsulation of drugs and longer circulation times [ 54 , 55 , 56 ].…”

Section: Liposomal-based Smart Drug Deliverymentioning

confidence: 99%

Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes

2023

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“…Liposomes display drug delivery, drug solubility, bioavailability of trapped medicines, absorption of medications into cells, and both in vivo and in vitro as a result of their special trait of containing a phospholipid bilayer. 12 Drugs can be distributed more widely throughout the body. For the purpose of creating vaccines, nutritional supplements, and cosmetics, the ADME profile of pharmaceuticals such as herbs, proteins and enzymes can be altered as necessary.…”

Section: Liposomesmentioning

confidence: 99%

Nanotechnology- based target drug delivery system

Kumar

Kumar²,

Shilsut³

et al. 2023

JPBS

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A nanotechnology can be described as the process of manipulating, studying, and manufacturing objects with a nanometer dimension. Through site-specific, targeted delivery of medicines, nanotechnology can benefit the treatment of chronic diseases in humans. Recent nanomedicine discoveries have led to the development of numerous outstanding drugs e.g., chemotherapeutics, biologics, immunotherapeutic, etc. The purpose of this chapter is to describe various nanocarriers that can be used to deliver therapeutic molecules.

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“…Typically, liposomes are composed of one or two lipid bilayers and possess a spherical shape. In general, liposomes are used for the delivery of both hydrophilic and lipophilic drugs, with the lipophilic drug being incorporated into the lipid bilayer and the hydrophilic drug being stabilized within the aqueous core ( Minocha and Kumar, 2022 ). PEGylation is performed to prevent liposomal elimination by the phagocytic system and enhance their circulation.…”

Section: Nanotechnology Approaches In Oc Treatmentmentioning

confidence: 99%

New trends in diagnosing and treating ovarian cancer using nanotechnology

Zhang

Ding

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

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Ovarian cancer stands as the fifth most prevalent cancer among women, causing more mortalities than any other disease of the female reproductive system. There are numerous histological subtypes of ovarian cancer, each of which has distinct clinical characteristics, risk factors, cell origins, molecular compositions, and therapeutic options. Typically, it is identified at a late stage, and there is no efficient screening method. Standard therapies for newly diagnosed cancer are cytoreductive surgery and platinum-based chemotherapy. The difficulties of traditional therapeutic procedures encourage researchers to search for other approaches, such as nanotechnology. Due to the unique characteristics of matter at the nanoscale, nanomedicine has emerged as a potent tool for creating novel drug carriers that are more effective and have fewer adverse effects than traditional treatments. Nanocarriers including liposomes, dendrimers, polymer nanoparticles, and polymer micelles have unique properties in surface chemistry, morphology, and mechanism of action that can distinguish between malignant and normal cells, paving the way for targeted drug delivery. In contrast to their non-functionalized counterparts, the development of functionalized nano-formulations with specific ligands permits selective targeting of ovarian cancers and ultimately increases the therapeutic potential. This review focuses on the application of various nanomaterials to the treatment and diagnosis of ovarian cancer, their advantages over conventional treatment methods, and the effective role of controlled drug delivery systems in the therapy of ovarian cancer.

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Nanostructure system: Liposome – A bioactive carrier in drug delivery systems

Cited by 9 publications

References 28 publications

Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes

Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes

Nanotechnology- based target drug delivery system

New trends in diagnosing and treating ovarian cancer using nanotechnology

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