Titanium and its alloys exhibit superior properties of high corrosion resistance, an excellent strength to weight ratio and outstanding stiffness among other things. However, their relatively low hardness and wear resistance limit their service life in high-performance applications of structure parts, gears and bearings, for example. The fabrication of a ceramic reinforced titanium matrix composite (TMC) coating could be one of the solutions to enhance the microhardness and wear resistance. Titanium carbide (TiC) is a preferable candidate due to the advantages of self-lubrication, low cost and a similar density and thermal expansion coefficient with titanium. The fabrication of TiC-TMC coatings onto titanium using a laser directed energy deposition (LDED) process has been conducted. The problems of TiC aggregation, low bonding quality and the generation of fabrication defects still exist. Considering ultrasonic vibration could generate acoustic steaming and transient cavitation actions in melted materials, which could homogenize the distribution of reinforcement materials and promote the dissolution of TiC into liquid titanium. In this study, for the first time, we investigate the ultrasonic vibration-assisted LDED of TiC-TMC coatings. The effects of ultrasonic vibration and reinforcement content on the phase compositions, reinforcement aggregation, bonding quality, fabrication defects and mechanical properties (including microhardness and wear resistance) of LDED deposited TiC-TMC coatings have been investigated. With the assistance of ultrasonic vibration, the aggregation of TiC was reduced, the porosity was decreased, the defects in the bonding interface were reduced and the mechanical properties including microhardness and wear resistance were increased. However, the excessive TiC content could significantly increase the TiC aggregation and manufacturing defects, resulting in the reduction of the mechanical properties.