Nanostructured carbon sorbent impregnated with betulin

Лавренов, А. В.; P’yanova, L. G.; Седанова, А. В.; Luzyanina, L. S.

doi:10.3103/s0361521915010085

Cited by 5 publications

(2 citation statements)

References 3 publications

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“…Betulin, [lup-20(29)-ene-3β,28-diol], is a pentacyclic triterpene that has drawn scientific interest due to its multiple biologic activities, mainly anti-inflammatory and antitumor ( Alakurtti et al, 2006 ); in spite of this promising pharmacological profile, its clinical use is severely restricted by its very poor bioavailability and bio-distribution in direct correlation to its low water solubility ( Drąg-Zalesińska et al, 2017 ). In an effort to overcome this drawback, several nanoformulations with betulin have been developed such as cyclodextrin complexes ( Soica C. et al, 2012 ), polymer-liposome nano-complexes ( Cho et al, 2007 ), nanoemulsions ( Dehelean et al, 2013 ), carbon nanotubes ( Saudagar and Dubey, 2014 ), nanostructured carbon sorbent ( Lavrenov et al, 2015 ); all studies reported an improved pharmacokinetic profile of the active compound therefore an increased bioavailability.…”

Section: Introductionmentioning

confidence: 99%

The Cytotoxic Effects of Betulin-Conjugated Gold Nanoparticles as Stable Formulations in Normal and Melanoma Cells

et al. 2018

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Gold nanoparticles are currently investigated as theranostics tools in cancer therapy due to their proper biocompatibility and increased efficacy related to the ease to customize the surface properties and to conjugate other molecules. Betulin, [lup-20(29)-ene-3β, 28-diol], is a pentacyclic triterpene that has raised scientific interest due to its antiproliferative effect on several cancer types. Herein we described the synthesis of surface modified betulin-conjugated gold nanoparticles using a slightly modified Turkevich method. Transmission electron microscopy (TEM) imaging, dynamic light scattering (DLS), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX) were used for the characterization of obtained gold nanoparticles. Cytotoxic activity and apoptosis assessment were carried out using the MTT and Annexin V/PI apoptosis assays. The in vitro results showed that betulin coated gold nanoparticles presented a dose-dependent cytotoxic effect and induced apoptosis in all tested cell lines.

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Section: Introductionmentioning

confidence: 99%

The Cytotoxic Effects of Betulin-Conjugated Gold Nanoparticles as Stable Formulations in Normal and Melanoma Cells

et al. 2018

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“…Получение энтеросорбентов из материалов органического происхождения (древесина, лигнин, торф и др. ), не прошедших стадию термической обработки, ограничивает их применение значительным содержанием пылевидной фракции, минеральных веществ и органическими соединеними, которые способны проявлять токсичные свойства [5,6]. Перспективным сырьем, позволяющим устранить или минимизировать содержание таких веществ, могут являться лигнины, выделенные из отходов растительной биомассы [7][8][9].…”

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Study of Enterosorption Activity of Carbon Sorbents Based on Organosolvent Lignin of Fir Wood

Veprikova¹,

P.²,

V.³

et al. 2018

J. Sib. Fed. Univ. Chem.

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The sorption activity of carbon sorbents obtained from organosolvent lignin of fir wood with respect to methylene blue, vitamin B 12 and gelatin was studied. The influence of pH values of model solutions on the sorption of methylene blue and vitamin B 12 was established. The data on the kinetics of sorption of these marker substances by carbon sorbents from lignin of fir woodwas presented. It was found that the ability of the studied sorbents to sorb the marker substancesexceeds the industrial activated carbons usedfor medical purposes.

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Formation of core-shell structures upon methane decomposition on metal-carbon composites with cobalt nanoparticles encapsulated into a porous carbon matrix

et al. 2016

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Nanostructured carbon sorbent impregnated with betulin

Cited by 5 publications

References 3 publications

The Cytotoxic Effects of Betulin-Conjugated Gold Nanoparticles as Stable Formulations in Normal and Melanoma Cells

The Cytotoxic Effects of Betulin-Conjugated Gold Nanoparticles as Stable Formulations in Normal and Melanoma Cells

Study of Enterosorption Activity of Carbon Sorbents Based on Organosolvent Lignin of Fir Wood

Formation of core-shell structures upon methane decomposition on metal-carbon composites with cobalt nanoparticles encapsulated into a porous carbon matrix

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