Nanostructured lipid carrier-based smart gel: a delivery platform for intra-articular therapeutics

Shinde, Chetan G.; Venkatesh, M. P.; Kumar, Tegginmat Pramod; Pai, Deeksha Ramananda

doi:10.1080/08916934.2020.1846184

Cited by 10 publications

(2 citation statements)

References 44 publications

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“…The characterization of NLCSs containing IMT was performed in terms of particle size, zeta potential and PDI values. As mentioned in previous studies, a narrow size distribution proves that Ostwald ripening can also be seen in the formulations [38,39]. Gupta et al [32] obtained that IMT-NLC exhibited a particle size of 148.80 ± 1.37 nm, PDI of 0.191 ± 0.017 and of zeta potential of −23.0 ± 1.5 mV.…”

Section: Discussionmentioning

confidence: 61%

An Innovative Formulation Based on Nanostructured Lipid Carriers for Imatinib Delivery: Pre-Formulation, Cellular Uptake and Cytotoxicity Studies

Gündoğdu

Ekinci

et al. 2022

Nanomaterials

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Imatinib (IMT) is a tyrosine kinase enzyme inhibitor and extensively used for the treatment of gastrointestinal stromal tumors (GISTs). A nanostructured lipid carrier system (NLCS) containing IMT was developed by using emulsification–sonication methods. The characterization of the developed formulation was performed in terms of its particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, loading capacity, sterility, syringeability, stability, in vitro release kinetics with mathematical models, cellular uptake studies with flow cytometry, fluorescence microscopy and cytotoxicity for CRL-1739 cells. The particle size, PDI, loading capacity and zeta potential of selected NLCS (F16-IMT) were found to be 96.63 ± 1.87 nm, 0.27 ± 0.15, 96.49 ± 1.46% and −32.7 ± 2.48 mV, respectively. F16-IMT was found to be stable, thermodynamic, sterile and syringeable through an 18 gauze needle. The formulation revealed a Korsmeyer–Peppas drug release model of 53% at 8 h, above 90% of cell viability, 23.61 µM of IC50 and induction of apoptosis in CRL-1739 cell lines. In the future, F16-IMT can be employed to treat GISTs. A small amount of IMT loaded into the NLCSs will be better than IMT alone for therapy for GISTs. Consequently, F16-IMT could prove to be useful for effective GIST treatment.

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Section: Discussionmentioning

confidence: 61%

An Innovative Formulation Based on Nanostructured Lipid Carriers for Imatinib Delivery: Pre-Formulation, Cellular Uptake and Cytotoxicity Studies

Gündoğdu

Ekinci

et al. 2022

Nanomaterials

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“…Curcumin (Cu) was loaded in an NLC polymeric gel composed of cetyl palmitate, Labrafac PG, Captex 200, labrasol, and Tween 80 for intra-articular administration. Cu NLC gel was observed to undergo a sol–gel transformation at 33.21 °C with a significant reduction in knee joint inflammation in rats [ 91 ].…”

Section: Thermosensitive In Situ Gels Loaded With Micro and Nanoparti...mentioning

confidence: 99%

Thermosensitive In Situ Gels for Joint Disorders: Pharmaceutical Considerations in Intra-Articular Delivery

Koland

Vadakkepushpakath

John

et al. 2022

Gels

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The intra-articular administration of conventional drug solutions or dispersions in joint diseases such as osteoarthritis has a relatively short retention time and, therefore, limited therapeutic effect. Thermosensitive polymer solutions that exhibit a sol–gel phase transition near body temperature after injection can prolong drug retention by providing a depot from which the drug release is sustained while relieving inflammation and preventing degradation of the joint complex. Thermosensitive hydrogels have in recent times garnered considerable attention in the intra-articular therapeutics of joint diseases such as osteoarthritis. Among the stimuli-responsive gelling systems, most research has focused on thermosensitive hydrogels. These gels are preferred over other stimuli-sensitive hydrogels since they have well-controlled in situ gelling properties and are also easier to load with drugs. Temperature-sensitive polymers, such as block copolymers or poloxamers, are frequently used to modify their gelation properties, usually in combination with other polymers. They are compatible with most drugs but may pose formulation challenges in terms of their low-response time, highly fragile nature, and low biocompatibility. The stability and biodegradability of implant hydrogels can control the drug release rate and treatment efficacy. This review stresses the application of thermosensitive gels in joint disorders and summarizes recent developments for intra-articular application, including the incorporation of nanoparticles. The hydrogel composition, drug release mechanisms, and the challenges involved in their formulation and storage are also discussed.

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Advances in local drug delivery technologies for improved rheumatoid arthritis therapy

An,

Yang,

Cui

et al. 2024

Advanced Drug Delivery Reviews

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Nanostructured lipid carrier-based smart gel: a delivery platform for intra-articular therapeutics

Cited by 10 publications

References 44 publications

An Innovative Formulation Based on Nanostructured Lipid Carriers for Imatinib Delivery: Pre-Formulation, Cellular Uptake and Cytotoxicity Studies

An Innovative Formulation Based on Nanostructured Lipid Carriers for Imatinib Delivery: Pre-Formulation, Cellular Uptake and Cytotoxicity Studies

Thermosensitive In Situ Gels for Joint Disorders: Pharmaceutical Considerations in Intra-Articular Delivery

Advances in local drug delivery technologies for improved rheumatoid arthritis therapy

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