Nanostructured lipid carrier surface modified with Eudragit RS 100 and its potential ophthalmic functions

Zhang, Wenji; Li, Xuedong; Ye, Tiantian; Fen, Chen; Yu, Shuai; Chen, Jianting; Yang, Xinggang; Yang, Na; Zhang, Jinsong; Liu, Jinlu; Pan, Wei-San; Kong, Jun

doi:10.2147/ijn.s63414

Cited by 30 publications

(14 citation statements)

References 23 publications

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“…In the recent years, many research efforts have been made to develop drug delivery systems that would prolong the pre-ocular retention and promote the absorption of drugs 3 4 5 . Nanostructured lipid carriers (NLC), a second generation of solid lipid nanoparticles (SLN), based on mixture of solid lipids with spatially incompatible liquid lipids combines many features beneficial for ocular application such as controlled drug release, high drug loading, good bioavailability and excellent tolerability 6 7 .…”

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confidence: 99%

Potential advantages of a novel chitosan-N-acetylcysteine surface modified nanostructured lipid carrier on the performance of ophthalmic delivery of curcumin

Liu

Pan

et al. 2016

Sci Rep

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The transient precorneal retention time and low penetration capacity into intraocular tissues are the key obstacles that hinder the ophthalmic drug delivery of many therapeutic compounds, especially for drugs with poor solubility and permeability. To break the stalemate, N-acetyl-L-cysteine functionalized chitosan copolymer (CS-NAC), which exhibit marked bioadhesion and permeation enhancing effect, was synthesized. The curcumin encapsulated NLC (CUR-NLC) was produced and optimized followed by surface absorption of CS-NAC. After coating, changed particle size from 50.76 ± 2.21 nm to 88.64 ± 1.25 nm and reversed zeta potential from −20.38 ± 0.39 mV to 22.51 ± 0.34 mV was observed. The in vitro CUR release from NLC was slower than that of CUR-NLC and chitosan hydrochlorides (CH) coated NLC due to the inter and/or intramolecular disulfide formation of thiomers on the surface of nanocarriers. The modification also significantly enhanced transcorneal penetration compared with CH-NLC and the uncoated ones. The effect on bioadhesion and precorneal retention were evaluated by in vivo imaging technique and ocular pharmacokinetics studies revealing that the clearance of the formulations was significantly delayed in the presence of CS-NAC and the effect was positively related to the degree of thiolation. In summary, CS-NAC-NLC presented a series of notable advantages for ophthalmic drug application.

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confidence: 99%

Potential advantages of a novel chitosan-N-acetylcysteine surface modified nanostructured lipid carrier on the performance of ophthalmic delivery of curcumin

Liu

Pan

et al. 2016

Sci Rep

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“…It has been used to deliver numerous vaginal antifungal, antiviral, antibacterial drugs, and other vaginal diseases in the form of nanocapsules and nanospheres [ 59 ]. Some studies have shown that Eudragit RS 100 may degrade into smaller fragments and remain in the body for a long time, leading to safety concerns as it accumulates inside the body and potentially induces immune disturbance [ 60 , 61 , 62 ]. Polyamidoamine dendrimers have been widely used in different drug delivery and biotechnology applications.…”

Section: Health Impact Of Conventional Polymer-based Materials In mentioning

confidence: 99%

The Role of Biopolymer-Based Materials in Obstetrics and Gynecology Applications: A Review

et al. 2021

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Biopolymers have gained tremendous attention in many daily life applications, including medical applications, in the past few years. Obstetrics and gynecology are two fields dealing with sensitive parts of the woman’s body and her newborn baby, which are normally associated with many issues such as toxicity, infections, and even gene alterations. Medical professions that use screening, examination, pre, and post-operation materials should benefit from a better understanding of each type of material’s characteristics, health, and even environmental effects. The underlying principles of biopolymer-based materials for different obstetric and gynecologic applications may discover various advantages and benefits of using such materials. This review presents the health impact of conventional polymer-based materials on pregnant women’s health and highlights the potential use of biopolymers as a safer option. The recent works on utilizing different biopolymer-based materials in obstetric and gynecologic are presented in this review, which includes suture materials in obstetric and gynecologic surgeries, cosmetic and personal care products, vaginal health, and drug delivery; as well as a wound dressing and healing materials. This review highlights the main issues and challenges of biopolymers in obstetric and gynecologic applications.

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“…The irritation of the eyes was scored according to the Draize scale. 29 The animals were sacrificed after the final observation, and the eyeballs were removed and stained with H＆E for histopathological evaluation.…”

Section: In Vivo Ocular Compatibility Testmentioning

confidence: 99%

<p>PLGA Nanoparticle Platform for Trans-Ocular Barrier to Enhance Drug Delivery: A Comparative Study Based on the Application of Oligosaccharides in the Outer Membrane of Carriers</p>

Jiang¹,

Jia²,

Qiu³

et al. 2020

IJN

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The trans-ocular barrier is a key factor limiting the therapeutic efficacy of triamcinolone acetonide. We developed a poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) surface modified respectively with 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD), chitosan oligosaccharide and trehalose. Determination of the drug/nanoparticles interactions, characterization of the nanoparticles, in vivo ocular compatibility tests, comparisons of their corneal permeability and their pharmacokinetics in aqueous humor were carried out. Methods: All PLGA NPs were prepared by the single emulsion and evaporation method and the drug-nanoparticle interaction was studied. The physiochemical features and in vitro corneal permeability of NPs were characterized while the aqueous humor pharmacokinetics was performed to evaluate in vivo corneal permeability of NPs. Ocular compatibility of NPs was investigated through Draize and histopathological test. Results: The PLGA NPs with lactide/glycolide ratio of 50:50 and small particle size (molecular weight 10 kDa) achieved optimal drug release and corneal permeability. Surface modification with different oligosaccharides resulted in uniform particle sizes and similar drug-nanoparticle interactions, although 2-HP-β-CD/PLGA NPs showed the highest entrapment efficiency. In vitro evaluation and aqueous humor pharmacokinetics further revealed that 2-HP-β-CD/PLGA NPs had greater trans-ocular permeation and retention compared to chitosan oligosaccharide/PLGA and trehalose/PLGA NPs. No ocular irritation in vivo was detected after applying modified/unmodified PLGA NPs to rabbit's eyes. Conclusion: 2-HP-β-CD/PLGA NPs are a promising nanoplatform for localized ocular drug delivery through topical administration.

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Nanostructured lipid carrier surface modified with Eudragit RS 100 and its potential ophthalmic functions

Cited by 30 publications

References 23 publications

Potential advantages of a novel chitosan-N-acetylcysteine surface modified nanostructured lipid carrier on the performance of ophthalmic delivery of curcumin

Potential advantages of a novel chitosan-N-acetylcysteine surface modified nanostructured lipid carrier on the performance of ophthalmic delivery of curcumin

The Role of Biopolymer-Based Materials in Obstetrics and Gynecology Applications: A Review

<p>PLGA Nanoparticle Platform for Trans-Ocular Barrier to Enhance Drug Delivery: A Comparative Study Based on the Application of Oligosaccharides in the Outer Membrane of Carriers</p>

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