Nanostructured Titanate with Different Metal Ions on the Surface of Metallic Titanium: A Facile Approach for Regulation of rBMSCs Fate on Titanium Implants

Abstract

Titanium (Ti) is widely used for load-bearing bio-implants, however, it is bio-inert and exhibits poor osteo-inductive properties. Calcium and magnesium ions are considered to be involved in bone metabolism and play a physiological role in the angiogenesis, growth, and mineralization of bone tissue. In this study, a facile synthesis approach to the in situ construction of a nanostructure enriched with Ca(2+) and Mg(2+) on the surface of titanium foil is proposed by inserting Ca(2+) and Mg(2+) into the interlayers of sodium titanate nanostructures through an ion-substitution process. The characteriz 0.67, and 0.73 nm ation results validate that cations can be inserted into the interlayer regions of the layered nanostructure without any obvious change of morphology. The cation content is positively correlated to the concentration of the solutions employed. The biological assessments indicate that the type and the amount of cations in the titanate nanostructure can alter the bioactivity of titanium implants. Compared with a Na(+) filled titanate nanostructure, the incorporation of divalent ions (Mg(2+) , Ca(2+) ) can effectively enhance protein adsorption, and thus also enhance the adhesion and differentiation ability of rat bone-marrow stem cells (rBMSCs). The Mg(2+) /Ca(2+) -titanate nanostructure is a promising implantable material that will be widely applicable in artificial bones, joints, and dental implants.

Multifunctional Copper-Containing Carboxymethyl Chitosan/Alginate Scaffolds for Eradicating Clinical Bacterial Infection and Promoting Bone Formation

“…Integrin subunits are responsible for the initial adhesion of cells. The known receptors in integrin and their ligand can be bound by metal ions, for example, Mg 2+ 31 . To the best of our knowledge, the effects of Cu 2+ ions on the cell adhesion in the scaffolds have been little studied.…”

Application of Polarization Modulation Infrared Reflection Absorption Spectrosocpy Under Electrochemical Control for Structural Studies of Biomimetic Assemblies

“…The adsorption of water and ions such as calcium, magnesium or phosphates on their surface ensures their high biocompatibility [96,97,99]. IR transmitting or absorbing substances such as silica, titanium, titanium oxides are not suitable for the IRRAS experiments.…”

Hierarchical hybrid nanostructures of Sn3O4 on N doped TiO2 nanotubes with enhanced photocatalytic performance

“…Then the resulted clear solution was transferred into a 100 mL Teflon-lined stainless steel autoclave, which was heated to 180℃ and maintained for 12 h. Then, the autoclave was cooled down to room temperature. The obtained composite nanotubes were washed with deionized water and ethanol to remove any ionic residual, then dried in an oven at 80℃ for 4 h. The as-fabricated sample was denoted as Sn 3 …”

“…The H 2 evolution experiments were carried out in a gas-closed circulation system. In a typical reaction, the 100 mg catalyst powder was dispersed in CH 3 OH aqueous solution using a magnetic stirrer (80 mL of distilled water + 20 mL of CH 3 S9. A Cu wire was connected to the FTO substrate with the silver colloid paste.…”