Nanostructures in Chinese herbal medicines (CHMs) for potential therapy

Zhang, Yali; Wang, Yalei; Ke, Yan; Deng, Qiuju; Li, Fangzhou; Liang, Xing‐Jie; Hua, Qian

doi:10.1039/d3nh00120b

Cited by 10 publications

(3 citation statements)

References 186 publications

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“…Recently, the constantly combined nanotechnology with TCM, has solved some application limitations of it, such as enhancing solubility, improving bioavailability, and increasing the targeting and penetration. [ 12 , 20 ] It is a promising strategy and provides more possibilities for TCM therapeutic effects. [ 8 , 21 ] There have been a number of reports describing nanoparticles existed in some Chinese herbal decoction, which exhibited a stable form for better effects, meaning a new possible mechanism of the action of Chinese medicine formula.…”

Section: Resultsmentioning

confidence: 99%

Traditional Chinese Medicine Formulae QY305 Reducing Cutaneous Adverse Reaction and Diarrhea by its Nanostructure

Zhang,

Wang,

Yan

et al. 2023

Advanced Science

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Traditional Chinese medicine (TCM) is widely used in clinical practice, including skin and gastrointestinal diseases. Here, a potential TCM QY305 (T‐QY305) is reported that can modulate the recruitment of neutrophil in skin and colon tissue thus reducing cutaneous adverse reaction and diarrhea induced by epidermal growth factor receptor inhibitors (EGFRIs). On another hand, the T‐QY305 formula, through regulating neutrophil recruitment features would highlight the presence of N‐QY305, a subunit nanostructure contained in T‐QY305, and confirm its role as potentially being the biomaterial conferring to T‐QY305 its pharmacodynamic features. Here, the clinical records of two patients are analyzed expressing cutaneous adverse reaction and demonstrate positive effect of T‐QY305 on the simultaneous inhibition of both cutaneous adverse reaction and diarrhea in animal models. The satisfying results obtained from T‐QY305, lead to further process to the isolation of N‐QY305 from T‐QY305, in order to demonstrate that the potency of T‐QY305 originates from the nanostructure N‐QY305. Compared to T‐QY305, N‐QY305 exhibits higher potency upon reducing adverse reactions. The data represent a promising candidate for reducing cutaneous adverse reaction and diarrhea, meanwhile proposing a new strategy to highlight the presence of nanostructures being the “King” of Chinese medicine formula as the pharmacodynamic basis.

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Section: Resultsmentioning

confidence: 99%

Traditional Chinese Medicine Formulae QY305 Reducing Cutaneous Adverse Reaction and Diarrhea by its Nanostructure

Zhang,

Wang,

Yan

et al. 2023

Advanced Science

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“…At present, novel drug delivery systems for anticancer drugs, including liposomes, microspheres, nanoparticles, microemulsions, cyclodextrins, polymer micelles, etc. , have achieved great success in delivering natural bioactive ingredients ( Ke et al, 2022 ; Zhang Y. L. et al, 2023 ). In fact, these techniques have also proven successful in delivering the active ingredients of hawthorn.…”

Section: Novel Drug Delivery Systemsmentioning

confidence: 99%

Hawthorn with “homology of medicine and food”: a review of anticancer effects and mechanisms

Zhou,

Nan,

et al. 2024

Front. Pharmacol.

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Over the past few years, there has been a gradual increase in the incidence of cancer, affecting individuals at younger ages. With its refractory nature and substantial fatality rate, cancer presents a notable peril to human existence and wellbeing. Hawthorn, a medicinal food homology plant belonging to the Crataegus genus in the Rosaceae family, holds great value in various applications. Due to its long history of medicinal use, notable effects, and high safety profile, hawthorn has garnered considerable attention and plays a crucial role in cancer treatment. Through the integration of modern network pharmacology technology and traditional Chinese medicine (TCM), a range of anticancer active ingredients in hawthorn have been predicted, identified, and analyzed. Studies have shown that ingredients such as vitexin, isoorientin, ursolic acid, and maslinic acid, along with hawthorn extracts, can effectively modulate cancer-related signaling pathways and manifest anticancer properties via diverse mechanisms. This review employs network pharmacology to excavate the potential anticancer properties of hawthorn. By systematically integrating literature across databases such as PubMed and CNKI, the review explores the bioactive ingredients with anticancer effects, underlying mechanisms and pathways, the synergistic effects of drug combinations, advancements in novel drug delivery systems, and ongoing clinical trials concerning hawthorn’s anticancer properties. Furthermore, the review highlights the preventive health benefits of hawthorn in cancer prevention, offering valuable insights for clinical cancer treatment and the development of TCM with anticancer properties that can be used for both medicinal and edible purposes.

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“…All or part of medicinal plants are used in medicine and will also be used as raw materials for the pharmaceutical industry, which have a wide range of medicinal and economic uses [ 2 ]. Especially in the field of traditional medicine represented by traditional Chinese medicine and Indian folk medicine, medicinal plants, as the main source of natural drugs, provide very important health care services for the population of developing countries [ 3 , 4 , 5 ]. With the rapid development of modern medicine, many clinical drugs still come from natural products extracted from medicinal plants [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Cultivable Endophyte Resources in Medicinal Plants and Effects on Hosts

Wang

Zhang

Hao

et al. 2023

Life

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With the increasing demand for medicinal plants and the increasing shortage of resources, improving the quality and yield of medicinal plants and making more effective use of medicinal plants has become an urgent problem to be solved. During the growth of medicinal plants, various adversities can lead to nutrient loss and yield decline. Using traditional chemical pesticides to control the stress resistance of plants will cause serious pollution to the environment and even endanger human health. Therefore, it is necessary to find suitable pesticide substitutes from natural ingredients. As an important part of the microecology of medicinal plants, endophytes can promote the growth of medicinal plants, improve the stress tolerance of hosts, and promote the accumulation of active components of hosts. Endophytes have a more positive and direct impact on the host and can metabolize rich medicinal ingredients, so researchers pay attention to them. This paper reviews the research in the past five years, aiming to provide ideas for improving the quality of medicinal plants, developing more microbial resources, exploring more medicinal natural products, and providing help for the development of research on medicinal plants and endophytes.

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Nanostructures in Chinese herbal medicines (CHMs) for potential therapy

Abstract: With its long clinical history, traditional Chinese medicine (TCM) has gained acceptance for its specific efficacy and safety in the treatment of multiple diseases. Nano-sized materials study of Chinese herbal...

Cited by 10 publications

References 186 publications

Traditional Chinese Medicine Formulae QY305 Reducing Cutaneous Adverse Reaction and Diarrhea by its Nanostructure

Traditional Chinese Medicine Formulae QY305 Reducing Cutaneous Adverse Reaction and Diarrhea by its Nanostructure

Hawthorn with “homology of medicine and food”: a review of anticancer effects and mechanisms

Cultivable Endophyte Resources in Medicinal Plants and Effects on Hosts

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