Nanostructuring lipid carriers using Ridolfia segetum (L.) Moris essential oil

Miranda, Margarida; Cruz, Maria Teresa; Vitorino, Carla; Cabral, Célia

doi:10.1016/j.msec.2019.109804

Cited by 36 publications

(19 citation statements)

References 55 publications

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“…For most formulations, the best fitting was obtained with the Korsmeyer–Peppas model. This model (

) allows the characterization of the different release mechanisms through evaluation of the diffusion release exponent (n) [ 39 ]. The n values obtained for formulations F1, F2, F7, F9, F10, F11, and RF suggest that these formulations have a Fickian behaviour.…”

Section: Resultsmentioning

confidence: 99%

Complying with the Guideline for Quality and Equivalence for Topical Semisolid Products: The Case of Clotrimazole Cream

et al. 2021

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Semisolids constitute a significant proportion of topical pharmaceutical dosage forms available on the market, with creams being considered profitable systems for releasing active substances into the skin. This work aimed at the development of a generic Clotrimazole topical cream, based on the assumptions that assist the development of such formulations. First, the critical parameters to obtain a final formulation as similar as possible to the reference product were defined. Then, the percentages of cetyl palmitate and octyldodecanol were identified as critical variables and chosen for optimization in further studies. A “quality by design” approach was then used to identify the effect of process variability on the structural and functional similarity (Q3) of the generic product qualitatively (Q1) and quantitatively (Q2). A two-factor central composite orthogonal design was applied and eleven different formulations were developed and subjected to physicochemical characterization and product performance studies. The results were used to estimate the influence of the two variables in the variation of the responses, and to determine the optimum point of the tested factors, using a design space approach. Finally, an optimized formulation was obtained and analysed in parallel with the reference. The obtained results agreed with the prediction of the chemometric analysis, validating the reliability of the developed multivariate models. The in vitro release and permeation results were similar for the reference and the generic formulations, supporting the importance of interplaying microstructure properties with product performance and stability. Lastly, based on quality targets and response constraints, optimal working conditions were successfully achieved.

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“…For most formulations, the best fitting was obtained with the Korsmeyer–Peppas model. This model (

Section: Resultsmentioning

confidence: 99%

Complying with the Guideline for Quality and Equivalence for Topical Semisolid Products: The Case of Clotrimazole Cream

et al. 2021

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“…The Korsmeyer-Peppas model ( k t c2 ) model allows us to characterize the different release mechanisms through the evaluation of the diffusion release exponent (c 2 ). Four scenarios may be possible: (i) c 2 close to 0.5—Fickian diffusion process, and non-Fickian diffusion process where (ii) 0.5 < c 2 < 1.0—anomalous transport, (iii) c 2 = 1.0—zero-order model, and finally (iv) c 2 >1.0—super case-II transport [ 81 ]. Taking into account this classification, it is seen that DoE formulations displayed a hybrid behavior between Fickian and anomalous (non-Fickian) transport [0.447 ± 0.024 (F 4 ) < c 2 < 0.629 ± 0.019 (F 12 )], ascribed to the differences in the microstructure network ( Table 8 ).…”

Section: Resultsmentioning

confidence: 99%

Progressing Towards the Sustainable Development of Cream Formulations

2020

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This work aims at providing the assumptions to assist the sustainable development of cream formulations. Specifically, it envisions to rationalize and predict the effect of formulation and process variability on a 1% hydrocortisone cream quality profile, interplaying microstructure properties with product performance and stability. This tripartite analysis was supported by a Quality by Design approach, considering a three-factor, three-level Box–Behnken design. Critical material attributes and process parameters were identified from a failure mode, effects, and criticality analysis. The impact of glycerol monostearate amount, isopropyl myristate amount, and homogenization rate on relevant quality attributes was estimated crosswise. The significant variability in product droplet size, viscosity, thixotropic behavior, and viscoelastic properties demonstrated a noteworthy influence on hydrocortisone release profile (112±2-196±7 μg/cm2/√h) and permeation behavior (0.16±0.03-0.97±0.08 μg/cm2/h), and on the assay, instability index and creaming rate, with values ranging from 81.9 to 120.5%, 0.031±0.012 to 0.28±0.13 and from 0.009±0.000 to 0.38±0.07 μm/s, respectively. The release patterns were not straightforwardly correlated with the permeation behavior. Monitoring the microstructural parameters, through the balanced adjustment of formulation and process variables, is herein highlighted as the key enabler to predict cream performance and stability. Finally, based on quality targets and response constraints, optimal working conditions were successfully attained through the establishment of a design space.

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“…Lipid-based nanoparticles are one of the most promising nanoencapsulation systems in the food industry because of their favorable properties, including the capacity to encapsulate hydrophilic and lipophilic compounds in the same structure, targetability, production with food-grade materials, and application in diverse products without undesirable effects [63]. Another advantage of the encapsulation in lipid nanostructures is the cytotoxicity reduction of the antimicrobials as compared with their free form, as some reports describe the reduction of toxicity of antimicrobial peptides loaded in liposomes [64], essential oils loaded in NLC [65] and natural extracts encapsulated in NLC [66]. The encapsulation of antibacterial agents, in addition to the direct effect on bacterial cells, has also been reported to be effective against biofilms, preventing their formation on surfaces and destroying adhered films [67], and could play an outstanding role in the reduction of foodborne diseases, particularly those caused by antibiotic-resistant bacteria.…”

Section: Encapsulation Of Natural Antimicrobials Into Lipid-based Nanostructuresmentioning

confidence: 99%

Lipid-Based Nanostructures for the Delivery of Natural Antimicrobials

2021

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Encapsulation can be a suitable strategy to protect natural antimicrobial substances against some harsh conditions of processing and storage and to provide efficient formulations for antimicrobial delivery. Lipid-based nanostructures, including liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid nanocarriers (NLCs), are valuable systems for the delivery and controlled release of natural antimicrobial substances. These nanostructures have been used as carriers for bacteriocins and other antimicrobial peptides, antimicrobial enzymes, essential oils, and antimicrobial phytochemicals. Most studies are conducted with liposomes, although the potential of SLNs and NLCs as antimicrobial nanocarriers is not yet fully established. Some studies reveal that lipid-based formulations can be used for co-encapsulation of natural antimicrobials, improving their potential to control microbial pathogens.

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Nanostructuring lipid carriers using Ridolfia segetum (L.) Moris essential oil

Cited by 36 publications

References 55 publications

Complying with the Guideline for Quality and Equivalence for Topical Semisolid Products: The Case of Clotrimazole Cream

Complying with the Guideline for Quality and Equivalence for Topical Semisolid Products: The Case of Clotrimazole Cream

Progressing Towards the Sustainable Development of Cream Formulations

Lipid-Based Nanostructures for the Delivery of Natural Antimicrobials

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