Nanotechnology: A Potential Tool in Exploring Herbal Benefits

Das, Santanu; Sharangi, Amit Baran

doi:10.1007/978-3-030-41464-1_2

Cited by 8 publications

(8 citation statements)

References 41 publications

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“…Nanostructures have attracted attention given their efficient active ingredients delivery and fractions extracted from plants [ 26 , 28 , 29 ]. In recent decades, numerous nanotechnology-based systems have been used for herbal drug nanoencapsulation; for instance polymeric nanoparticles, metal and inorganic nanoparticles, solid lipid nanoparticles, polymeric and phospholipid micelles, and liposomes [ 29 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

“…However, despite the biological potential of the substances in vegetal matrixes, variable physicochemical characteristics can be observed, which affect the bioavailability and limit the biological action [ 24 , 25 ]. Natural extracts are still poorly clinically used because their highly water solubility hinders phytochemicals absorption, as they are unable to permeate the lipid membranes of cells [ 26 ]. Furthermore, phytochemicals may have an inadequate molecular size and physicochemical instability, requiring high concentrations in biological systems for an effective pharmacological action [ 12 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

“…Natural extracts are still poorly clinically used because their highly water solubility hinders phytochemicals absorption, as they are unable to permeate the lipid membranes of cells [ 26 ]. Furthermore, phytochemicals may have an inadequate molecular size and physicochemical instability, requiring high concentrations in biological systems for an effective pharmacological action [ 12 , 26 , 27 , 28 ]. Thus, to plan adequate alternatives to overcome these restrictions and enable to applicate plant extracts for different purposes, including the mood disorders treatment, is imperative.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, to plan adequate alternatives to overcome these restrictions and enable to applicate plant extracts for different purposes, including the mood disorders treatment, is imperative. Contemplating a strategic tool for obtain platforms for the bioactive compounds incorporation, the development of nanotechnology-based formulations stands out [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

“…Nanoscience is an area with great potential for technological applications, where nanotechnology is considered a new complementary tool for the improvement and development of products [ 29 ]. Nano-based formulations present some advantages given the nanometric size and physicochemical characteristics of carriers, such as improved stability, solubility and bioavailability of phytochemicals, controlled release of plant active constituents, decreased side effects, reduced required dose for promoting biological effects, and enhanced pharmacological action [ 26 , 30 , 31 ]. Given the above, the potentialities of V. ashei leaves and the promising association with nanocarriers compelled us to develop polymeric nanostructures containing V. ashei leaves hydroalcoholic extract (NPHEV) and to evaluate the in vitro antioxidant effects and in vivo antidepressant-like potential.…”

Section: Introductionmentioning

confidence: 99%

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Nanoencapsulation of Vaccinium ashei Leaf Extract in Eudragit® RS100-Based Nanoparticles Increases Its In Vitro Antioxidant and In Vivo Antidepressant-like Actions

et al. 2023

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Depression is a major psychiatric disorder in Brazil and worldwide. Vaccinium ashei (V. ashei) leaves are cultivation by-products with high bioactive compound levels. Here, a hydroalcoholic extract of V. ashei leaves (HEV) was associated with Eudragit® RS100-based nanoparticles (NPHEV) to evaluate the in vitro antioxidant and in vivo antidepressant-like effects. Interfacial deposition of the preformed polymer method was used for NPHEV production. The formulations were evaluated regarding physicochemical characteristics, antioxidant activity (DPPH radical scavenging and oxygen radical absorbance capacity), and antidepressant-like action (1–25 mg/kg, single intragastric administration) assessed in forced swimming and tail suspension tests in male Balb-C mice. The NPHEV presented sizes in the nanometric range (144–206 nm), positive zeta potential values (8–15 mV), polydispersity index below 0.2, and pH in the acid range. The phenolic compound content was near the theoretical values, although the rutin presented higher encapsulation efficiency (~95%) than the chlorogenic acid (~60%). The nanoencapsulation improved the HEV antioxidant effect and antidepressant-like action by reducing the immobility time in both behavioral tests. Hence, Eudragit® RS100 nanoparticles containing HEV were successfully obtained and are a promising alternative to manage depression.

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