Nanotechnology and quantum science enabled advances in neurological medical applications: diagnostics and treatments

Batool, Sadia; Nabipour, Hafezeh; Ramakrishna, Seeram; Mozafari, Masoud

doi:10.1007/s11517-022-02664-3

Cited by 9 publications

(7 citation statements)

References 76 publications

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“…Nanotechnology has been shown to have several medical applications, including facilitating wound healing, the treatment of neurological and cardiac disorders [ 14 , 15 , 16 ], and the management of arthritic pain. Although evidence supporting the use of nanotechnology for pain associated with surgery is still lacking, the use of the NeuroCuple™ does not require extensive training and therefore represents a technique that can be used on a large scale and may represent an interesting alternative to the use of opioids in surgical patients undergoing skeletal-muscle procedures.…”

Section: Discussionmentioning

confidence: 99%

Use of Nanotechnology as an Alternative to Opioids for Post-operative Pain Management Following TKA

Chelly,

Plakseychuk,

Schott

2023

jocr

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Introduction: In response to the current opioid crisis, there is a great interest to develop non-pharmacologic approaches to post-operative pain management for patients undergoing total knee arthroplasty (TKA). Case Report: We report a case of a patient whose post-operative pain following TKA was managed using the newly designed NeuroCuple™ device, a patch based on the use of nanotechnology. The NeuroCuple™ device was placed above the knee by the patient at home. The use of the NeuroCuple™ device allowed the patient completely avoid the use of any opioids at home. Conclusion: Our report suggests that the use of the NeuroCuple™ device may represent an interesting alternative to opioids for the peri-operative management of pain following a primary, unilateral TKA. Keywords: Primary knee arthroplasty, peri-operative pain management, nanotechnology.

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Section: Discussionmentioning

confidence: 99%

Use of Nanotechnology as an Alternative to Opioids for Post-operative Pain Management Following TKA

Chelly,

Plakseychuk,

Schott

2023

jocr

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“…The medical application of nanotechnology is recent and considered to have limitless indications because this technology allows the transport and delivery of nanoparticles, micelles, quantum dots, liposomes, nanofibers, and nanoscaffolds [22][23][24][25][26][27][28][29][30][31][32]. Most medical indications for nanotechnology are nanoscale based to improve drug delivery systems for cancer and chronic wound infection, measure neuronal and cardiac cellular electrical activity and cell-to-cell interactions, and monitor metabolic function at the cellular level.…”

Section: Discussionmentioning

confidence: 99%

Role of the NeuroCuple™ Device for the Postoperative Pain Management of Patients Undergoing Unilateral Primary Total Knee and Hip Arthroplasty: A Pilot Prospective, Randomized, Open-Label Study

Chelly,

Klatt,

Groff

et al. 2023

JCM

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Background: The potential effectiveness of the non-pharmacological and nanotechnology-based NeuroCuple™ device in reducing postoperative surgical pain and opioid consumption remains unknown. Methods: This randomized controlled open-label study was conducted in patients undergoing a primary unilateral total knee or total hip arthroplasty. In the recovery room, patients were randomized to receive either standard of care (control group) or standard of care plus two NeuroCuple™ devices. The outcome variables included pain and opioid consumption (oral morphine equivalent, OME in milligrams). Results: A total of 69 patients were randomized to either the NeuroCuple™ group (n = 38) or the control group (n = 31). Use of the NeuroCuple™ devices was associated with a significant 34% reduction in pain at rest (means of area under the curve: 6.3 vs. 9.5; p = 0.018) during postoperative days 1–3. Opioid consumption was reduced by 9%. More importantly, use of the NeuroCuple™ devices reduced the number of patients requesting an opioid prescription following discharge from the hospital by 52% (26% vs. 55%, p = 0.016). Conclusions: Our data suggest that the NeuroCuple™ device may be an effective non-pharmacological alternative to opioids to manage postoperative pain following unilateral arthroplasty due to its ability to reduce postoperative opioid use.

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“…SDG 3: QTs have the potential to revolutionize healthcare and medicine (Batool et al, 2022 ; Ur Rasool et al, 2023 ). Quantum sensors can detect and diagnose diseases with unprecedented sensitivity (Tarasov et al, 2020 ).…”

Section: Quantum Technology: Applications and Potential Driver To Del...mentioning

confidence: 99%

Quantum technology for development framework as a tool for science diplomacy

Mafu,

Senekane

2023

Front. Res. Metr. Anal.

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The state-of-the-art quantum technologies leverage the unique principles of quantum mechanics, which include quantization, uncertainty principle, interference, entanglement and decoherence, to produce useful devices and scientific advancements not possible with classical technologies. As a result, quantum technologies, in particular, offer specific advantages that make communications networks secure and unbreakable and devices with unprecedented levels of accuracy, responsiveness, reliability, scalability and efficiency than classical emerging technologies. These capabilities can contribute significantly to addressing energy, agriculture, climate change, national security, healthcare, education and economic growth challenges. Unfortunately, these developments in these areas have not been evenly distributed between the Global North and the Global South, inadvertently creating a societal and economic gap. Closing this gap is critical to creating a more inclusive and sustainable future for all, thus delivering key sustainable goals. Therefore, to close this gap, this article proposes a quantum diplomacy framework as a means to deliver science diplomacy. Moreover, we discuss how emerging quantum technologies could profoundly impact all 17 United Nations Sustainable Development Goals. We consider this work a timely and vital intervention to prevent the gap from increasing.

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Nanotechnology and quantum science enabled advances in neurological medical applications: diagnostics and treatments

Cited by 9 publications

References 76 publications

Use of Nanotechnology as an Alternative to Opioids for Post-operative Pain Management Following TKA

Use of Nanotechnology as an Alternative to Opioids for Post-operative Pain Management Following TKA

Role of the NeuroCuple™ Device for the Postoperative Pain Management of Patients Undergoing Unilateral Primary Total Knee and Hip Arthroplasty: A Pilot Prospective, Randomized, Open-Label Study

Quantum technology for development framework as a tool for science diplomacy

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