Nanotechnology Approaches for Intraprocedural Molecular Diagnostics

Castro, Cesar M.; Im, Hyungsoon; Lee, Hakho; Weissleder, Ralph

doi:10.1007/978-1-4939-2326-7_12

Cited by 1 publication

(1 citation statement)

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“…The rapid development of nanobiotechnology can be a crucial step of mankind towards creation of novel methods and drugs for the treatment of various diseases [1,2]. New opportunities in medicine that will be available through advanced nanotechnology range from diagnostics of human body [3] to real means of practical therapy [4]. In particular, the creation of nanodrugs will promote a more specific therapy and provide local action, increasing treatment efficacy and reducing side effects.…”

Section: Introductionmentioning

confidence: 99%

Smart nanocarriers for drug delivery: controllable LSPR tuning

Lopatynskyi¹

2016

Semicond. Phys. Quantum Electron. Optoelectron.

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Gold nanostructures are considered as a potential platform for building smart nanocarriers that will form the basis of novel methods of targeted delivery and controlled release of drugs. However, to ensure maximum efficiency of gold nanoparticles upon the drug release via the plasmon-enhanced photothermal effect, it is necessary to optimize their spectral parameters for operation in the human body that requires both theoretical research and development of appropriate methods for nanostructures fabrication. In this work, mathematical modeling of light extinction spectral dependences for gold nanostructures of different morphology was performed to determine their geometric parameters that provide the occurrence of localized surface plasmon resonance (LSPR) in the red and near infrared regions of the spectrum, where the transparency window of biological tissues exists. Based on the results of previous studies and computer modeling, using hollow gold nanoshells to construct smart nanocarriers was found to be most reasonable. A protocol for production of these nanoparticles based on "silver-gold" galvanic replacement reaction, which is accompanied by a controlled shift of the LSPR wavelength position, was proposed and described in detail. It is shown that the loading of model biomolecules in hollow gold nanoshells significantly changes the output optical parameters of the system under investigation, which should be taken into account for matching with the laser excitation wavelength during the development of smart nanocarriers.

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Section: Introductionmentioning

confidence: 99%

Smart nanocarriers for drug delivery: controllable LSPR tuning

Lopatynskyi¹

2016

Semicond. Phys. Quantum Electron. Optoelectron.

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Nanotechnology Approaches for Intraprocedural Molecular Diagnostics

Cited by 1 publication

References 55 publications

Smart nanocarriers for drug delivery: controllable LSPR tuning

Smart nanocarriers for drug delivery: controllable LSPR tuning

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