Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

Onugwu, Adaeze Linda; Nwagwu, Chinekwu Sherridan; Onugwu, Obinna Sabastine; Echezona, Adaeze Chidiebere; Agbo, Chinazom Precious; Ihim, Stella Amarachi; Emeh, Prosper; Nnamani, Petra O.; Attama, Anthony A.; Khutoryanskiy, Vitaliy V.

doi:10.1016/j.jconrel.2023.01.018

Cited by 108 publications

(53 citation statements)

References 195 publications

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“…The former includes the cornea, conjunctiva, iris, ciliary body, crystalline lens, and aqueous humor, while the latter includes the sclera, choroid, retina, and vitreous ( Figure 1 ) [ 2 ]. The anterior and posterior segments are affected by different pathogenic factors [ 13 , 25 ], resulting in different types of diseases, making ocular drug delivery one of the most challenging tasks for researchers [ 26 ]. The following is a brief overview of the relevant ocular structures that affect drug delivery.…”

Section: Ocular Structure and Barriersmentioning

confidence: 99%

“…In recent years, scientists have investigated and created many novel types of ophthalmic formulations, including micelles, liposomes, nanoparticles, nanosuspensions, dendritic polymers, microneedles, cubosomes, niosomes, nanowafers, etc., providing a number of alternatives to the drug delivery of traditional ophthalmic formulations [ 13 ]. Nanogels are formed from natural polymers, synthetic polymers, or a combination thereof, and their three-dimensional network structure allows for the encapsulation of small molecules, oligonucleotides, and even proteins [ 14 ], whose unique characteristics make it possible for drug delivery, diagnostics, and imaging and have great potential for application in the biomedical, tissue engineering, and pharmaceutical fields [ 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Advances in Nanogels for Topical Drug Delivery in Ocular Diseases

Tao

Xie

et al. 2023

Gels

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Nanotechnology has accelerated the development of the pharmaceutical and medical technology fields, and nanogels for ocular applications have proven to be a promising therapeutic strategy. Traditional ocular preparations are restricted by the anatomical and physiological barriers of the eye, resulting in a short retention time and low drug bioavailability, which is a significant challenge for physicians, patients, and pharmacists. Nanogels, however, have the ability to encapsulate drugs within three-dimensional crosslinked polymeric networks and, through specific structural designs and distinct methods of preparation, achieve the controlled and sustained delivery of loaded drugs, increasing patient compliance and therapeutic efficiency. In addition, nanogels have higher drug-loading capacity and biocompatibility than other nanocarriers. In this review, the main focus is on the applications of nanogels for ocular diseases, whose preparations and stimuli-responsive behaviors are briefly described. The current comprehension of topical drug delivery will be improved by focusing on the advances of nanogels in typical ocular diseases, including glaucoma, cataracts, dry eye syndrome, and bacterial keratitis, as well as related drug-loaded contact lenses and natural active substances.

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Section: Ocular Structure and Barriersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Advances in Nanogels for Topical Drug Delivery in Ocular Diseases

Tao

Xie

et al. 2023

Gels

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“…Liposomes are extensively regarded and investigated as lipid-based drug delivery vehicles, not only due to the fundamental raw material for their manufacture, phospholipids, is an inherent element in human cells, making them friendly and non-immunogenic, but also since they can be manufactured as nanoscale particles, making them simpler to cross intrinsic limitations like blood vessel barriers and cellular membranes. In addition to antibacterial medication delivery, they are now employed in a variety of purposes, including as the treatment of cancer [81][82][83], eye illnesses [84,85], and neurodegenerative diseases [86,87].…”

Section: Lipid-based Nano-formulations As Antibacterial Theranosticsmentioning

confidence: 99%

Nanoparticle formulations for therapeutic delivery, pathogen imaging and theranostic applications in bacterial infections

Jiang¹,

Ding²,

Liu³

2023

Theranostics

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Pathogenic bacterial infections represent an ever-growing crisis, now significantly threatening life expectancy across the worldwide population and thus novel approaches to tackle this issue are urgently needed. The application of nanotechnology in recent years has opened up new horizons in the selective or specific delivery of drugs or imaging agents to infectious sites. In particular, the development of nanoparticles for both delivery of active substances and imaging of infection sites is now gathering much interest. Although still in its infancy, the field of antibacterial nanomedicines provides exciting new possibilities to combat multi-resistant bacterial infections and shows great promise for personalized medicine in antibacterial stewardship. This review examines nanoparticle-based formulations used for therapeutic delivery, pathogen tracking in diagnosis, and combined “theranostic” approaches to more effectively treating bacterial infections.

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“…Normally there are two different ways for drug delivery to the eyes; local injection, which is traumatic and less acceptable and only applied by the medical personnel, and topical administration, which includes different types of eye drops and gels and is more user friendly [ 19 , 20 ]. Despite the efforts made, still there are some limitations in producing high performance topical therapeutic compounds for ocular disease treatment.…”

Section: Ocular Anatomy and Diseasesmentioning

confidence: 99%

Application of Convergent Science and Technology toward Ocular Disease Treatment

et al. 2023

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Eyes are one of the main critical organs of the body that provide our brain with the most information about the surrounding environment. Disturbance in the activity of this informational organ, resulting from different ocular diseases, could affect the quality of life, so finding appropriate methods for treating ocular disease has attracted lots of attention. This is especially due to the ineffectiveness of the conventional therapeutic method to deliver drugs into the interior parts of the eye, and the also presence of barriers such as tear film, blood-ocular, and blood-retina barriers. Recently, some novel techniques, such as different types of contact lenses, micro and nanoneedles and in situ gels, have been introduced which can overcome the previously mentioned barriers. These novel techniques could enhance the bioavailability of therapeutic components inside the eyes, deliver them to the posterior side of the eyes, release them in a controlled manner, and reduce the side effects of previous methods (such as eye drops). Accordingly, this review paper aims to summarize some of the evidence on the effectiveness of these new techniques for treating ocular disease, their preclinical and clinical progression, current limitations, and future perspectives.

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Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

Cited by 108 publications

References 195 publications

Advances in Nanogels for Topical Drug Delivery in Ocular Diseases

Advances in Nanogels for Topical Drug Delivery in Ocular Diseases

Nanoparticle formulations for therapeutic delivery, pathogen imaging and theranostic applications in bacterial infections

Application of Convergent Science and Technology toward Ocular Disease Treatment

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