Nanotechnology-Based Drug Delivery Systems for Treatment of Hyperproliferative Skin Diseases - A Review

Santos, Fernanda Kolenyak dos; Oyafuso, Márcia Helena; Kiill, Charlene P.; Daflon-Gremião, Maria Palmira; Chorilli, Marlus

doi:10.2174/157341313805117857

Cited by 8 publications

(1 citation statement)

References 92 publications

(121 reference statements)

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“…Thus, the antioxidant effect of CNCs could protect hydroquinone in the CNC‐HDQ complex from oxidation . The HDQ‐CNC complex showed an approximately sustained release profile of HDQ over 4 h. The sustained delivery of therapeutic agent to skin using nanoparticles could improve the efficacy and reduce the side‐effects of these agents .…”

Section: Discussionmentioning

confidence: 99%

The Use of Cellulose Nanocrystals for Potential Application in Topical Delivery of Hydroquinone

Taheri

Mohammadi

2014

Chem Biol Drug Des

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Nanotechnology-based drug delivery systems can enhance drug permeation through the skin and improve the drug stability. The biodegradability and biocompatibility of cellulose nanocrystals have made these nanoparticles good candidates to use in biomedical applications. The hyperpigmentation is a common skin disorder that could be caused by number of reasons such as sun exposure and pregnancy. Hydroquinone could inhibit the production of melanin and eliminate the discolorations of skin. This study is aimed at introducing cellulose nanocrystals as suitable carriers for drug delivery to skin. Prepared cellulose nanocrystals were characterized by dynamic light scattering and atomic force microscopy. The size of cellulose nanocrystals determined using dynamic light scattering was 301 ± 10 nm. Hydroquinone-cellulose nanocrystal complex was prepared by incubating of hydroquinone solution in cellulose nanocrystals suspension. The size of hydroquinone-cellulose nanocrystal complex determined using dynamic light scattering was 310 ± 10 nm. The hydroquinone content of the hydroquinone-cellulose complex was determined using UV/vis spectroscopy. Hydroquinone was bound to cellulose nanocrystals representing 79.3 ± 2% maximum binding efficiency when 1.1 mg hydroquinone was added to 1 mL of cellulose nanocrystals suspension (2 mg cellulose nanocrystal). The hydroquinone-cellulose nanocrystal complex showed an approximately sustained release profile of hydroquinone. Approximately, 80% of bound hydroquinone released in 4 h.

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Section: Discussionmentioning

confidence: 99%