Nanotechnology-based lipid systems applied to resistant bacterial control: A review of their use in the past two decades

Ramos, Matheus Aparecido dos Santos; Toledo, Luciani Gaspar de; Spósito, Larissa; Marena, Gabriel Davi; Lima, Laura Caminitti de; Fortunato, Giovanna Capaldi; Araújo, Jennifer Thayanne Cavalcante de; Bauab, Taís Maria; Chorilli, Marlus

doi:10.1016/j.ijpharm.2021.120706

Cited by 15 publications

(5 citation statements)

References 151 publications

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“…This study revealed that all tested NCs were efficient for photoprotection of the phytopharmaceutical, with NLCs offering the best pharmacological performance, provided the matrix fluidity was tuned for optimized skin occlusion and drug release rate [ 80 ]. In line with this, multiple benefits of SLNs/NLCs-mediated delivery of natural and synthetic antimicrobials have been advocated in the recent literature [ 81 , 82 , 83 ], including for fighting multidrug-resistant (MDR) infections [ 84 , 85 ]. Thus, a new “nanoantibiotic era” is on the rise [ 86 ] that will likely have great impact on the management of complicated skin and skin structure infections (cSSTI), given the unique ability of lipid-based NCs to overcome the skin barrier [ 87 ].…”

Section: Overview Of Current Methods For Dermal and Transdermal Drug Deliverymentioning

confidence: 99%

The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

Gomes

Aguiar

Ferraz

et al. 2021

IJMS

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Topical and transdermal delivery systems are of undeniable significance and ubiquity in healthcare, to facilitate the delivery of active pharmaceutical ingredients, respectively, onto or across the skin to enter systemic circulation. From ancient ointments and potions to modern micro/nanotechnological devices, a variety of approaches has been explored over the ages to improve the skin permeation of diverse medicines and cosmetics. Amongst the latest investigational dermal permeation enhancers, ionic liquids have been gaining momentum, and recent years have been prolific in this regard. As such, this review offers an outline of current methods for enhancing percutaneous permeation, highlighting selected reports where ionic liquid-based approaches have been investigated for this purpose. Future perspectives on use of ionic liquids for topical delivery of bioactive peptides are also presented.

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Section: Overview Of Current Methods For Dermal and Transdermal Drug Deliverymentioning

confidence: 99%

The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

Gomes

Aguiar

Ferraz

et al. 2021

IJMS

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“… 6 Several studies have reported the effectiveness of nanomaterial-based therapy with the emergence of antimicrobial-resistant pathogenic bacteria and new viruses. 93 − 96 …”

Section: Treatment Strategies For Covid-19mentioning

confidence: 99%

“…For example, the isolation of antiviral antibodies produced in healed patients from blood plasma was used . Several studies have reported the effectiveness of nanomaterial-based therapy with the emergence of antimicrobial-resistant pathogenic bacteria and new viruses. − …”

Section: Treatment Strategies For Covid-19mentioning

confidence: 99%

Nanostructures for the Prevention, Diagnosis, and Treatment of SARS-CoV-2: A Review

Kiremitler

Kemerli

Kayacı

et al. 2022

ACS Appl. Nano Mater.

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Scientists, doctors, engineers, and even entire societies have become aware of the seriousness of the COVID-19 infection and are taking action quickly, using all the tools from protection to treatment against coronavirus SARS-CoV-2. Especially in this sense, scientific approaches and materials using nanotechnology are frequently preferred. In this review, we focus on how nanoscience and nanotechnology approaches can be used for protective equipment, diagnostic and treatment methods, medicine, and vaccine applications to stop the coronavirus SARS-CoV-2 and prevent its spread. SARS-CoV-2, which itself can be considered as a core–shell nanoparticle, can interact with various materials around it and remain bound for variable periods of time while maintaining its bioactivity. These applications are especially critical for the controlled use of disinfection systems. One of the most important processes in the fight against coronavirus is the rapid diagnosis of the virus in humans and the initiation of isolation and treatment processes. The development of nanotechnology-based test and diagnostic kits is another important research thrust. Nanotechnological therapeutics based on antiviral drug design and nanoarchitecture vaccines have been vital. Nanotechnology plays critical roles in the production of protective film surfaces for self-cleaning and antiviral masks, gloves, and laboratory clothes. An overview of literature studies highlighting nanotechnology and nanomaterial-based approaches to combat SARS-CoV-2 is presented.

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“…Within this context, the oil nanodroplets can act as a reservoir of lipophilic drugs, such as fatty acids and monoglycerides, that can be delivered to the lipid layer of the tear film. Subsequent fusion of NE oil droplets with bacterial cell membranes could potentially occur and result in releasing the biologically active components to destabilize the pathogen [122].…”

Section: Ocular Applicationsmentioning

confidence: 99%

“…Nowadays, SLNs, NLCs, and lipid NCs are emerging as perhaps even better carriers of fatty acids and especially monoglycerides, in which case these molecules can simultaneously act as the building blocks and biologically active compounds [53,127,128]. However, the structural features of these lipid nanoparticles such as size and surface properties, loading capacity, preparation method suitable for large-scale production, efficiency, and safety still need to be investigated and optimized [122]. There also needs to be a more rigorous focus on safety, including in vitro and in vivo cytotoxicity evaluation and dosing considerations-a topic which is covered in some reports in vitro, as discussed above, but most reports focus on therapeutic performance only.…”

Section: Translational Opportunitiesmentioning

confidence: 99%

Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

Tan

Yoon

Cho

et al. 2021

IJMS

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There is enormous interest in utilizing biologically active fatty acids and monoglycerides to treat phospholipid membrane-related medical diseases, especially with the global health importance of membrane-enveloped viruses and bacteria. However, it is difficult to practically deliver lipophilic fatty acids and monoglycerides for therapeutic applications, which has led to the emergence of lipid nanoparticle platforms that support molecular encapsulation and functional presentation. Herein, we introduce various classes of lipid nanoparticle technology and critically examine the latest progress in utilizing lipid nanoparticles to deliver fatty acids and monoglycerides in order to treat medical diseases related to infectious pathogens, cancer, and inflammation. Particular emphasis is placed on understanding how nanoparticle structure is related to biological function in terms of mechanism, potency, selectivity, and targeting. We also discuss translational opportunities and regulatory needs for utilizing lipid nanoparticles to deliver fatty acids and monoglycerides, including unmet clinical opportunities.

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Nanotechnology-based lipid systems applied to resistant bacterial control: A review of their use in the past two decades

Cited by 15 publications

References 151 publications

The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

Nanostructures for the Prevention, Diagnosis, and Treatment of SARS-CoV-2: A Review

Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

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