Nanotechnology in Advanced Medical Devices

Habib-Ullah, Sabeeh; Fei, Dan; Ge, Yi

doi:10.1007/978-1-4614-2140-5_8

Cited by 2 publications

(2 citation statements)

References 90 publications

(91 reference statements)

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“…One of the devices that can address these issues is the quartz crystal microbalance with energy dissipation monitoring (QCM-D). The QCM-D is an ultrasensitive device that can monitor the adsorbed mass on a nanogram scale and the resulting adlayer viscoelasticity. − Self-assembled monolayers (SAMs) consisting of linear-chain molecules with tunable terminal groups functionalized on atomically flat QCM sensors (surface roughness ∼1 nm) can deconvolute the influence of surface chemistry from substrate topography on bacterial attachment. Moreover, the QCM-D allows the continuous injection of the bacterial suspension to a closed module at small-volume flow rates to minimize gravitational and drying effects or to mimic in vivo fluid flow on biomedical devices.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Three-Dimensional Bacterial Adhesion Manner on Model Organic Surfaces Using Quartz Crystal Microbalance with Energy Dissipation Monitoring

Latag

Nakamura

Palai

et al. 2023

ACS Appl. Bio Mater.

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Bacterial biofilms reduce the performance and efficiency of biomedical and industrial devices. The initial step in forming bacterial biofilms is the weak and reversible attachment of the bacterial cells onto the surface. This is followed by bond maturation and secretion of polymeric substances, which initiate irreversible biofilm formation, resulting in stable biofilms. This implies that understanding the initial reversible stage of the adhesion process is crucial to prevent bacterial biofilm formation. In this study, we analyzed the adhesion processes of E. coli on self-assembled monolayers (SAMs) with different terminal groups using optical microscopy and quartz crystal microbalance with energy dissipation (QCM-D) monitoring. We found that a considerable number of bacterial cells adhere to hydrophobic (methyl-terminated) and hydrophilic protein-adsorbing (amine- and carboxy-terminated) SAMs forming dense bacterial adlayers while attaching weakly to hydrophilic protein-resisting SAMs [oligo(ethylene glycol) (OEG) and sulfobetaine (SB)], forming sparse but dissipative bacterial adlayers. Moreover, we observed positive shifts in the resonant frequency for the hydrophilic protein-resisting SAMs at high overtone numbers, suggesting how bacterial cells cling to the surface using their appendages as explained by the coupled-resonator model. By exploiting the differences in the acoustic wave penetration depths at each overtone, we estimated the distance of the bacterial cell body from different surfaces. The estimated distances provide a possible explanation for why bacterial cells tend to attach firmly to some surfaces and weakly to others. This result is correlated to the strength of the bacterium–substratum bonds at the interface. Elucidating how the bacterial cells adhere to different surface chemistries can be a suitable guide in identifying surfaces with a more significant probability of contamination by bacterial biofilms and designing bacteria-resistant surfaces and coatings with excellent bacterial antifouling characteristics.

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Section: Introductionmentioning

confidence: 99%

Investigation of Three-Dimensional Bacterial Adhesion Manner on Model Organic Surfaces Using Quartz Crystal Microbalance with Energy Dissipation Monitoring

Latag

Nakamura

Palai

et al. 2023

ACS Appl. Bio Mater.

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“…1,2 Contrary to what could be perceived as a novel field with relatively limited practical value, many nanotechnology-based medical products are finding their way into the market while others have been already used in daily clinical practice for several decades, with applications in drug delivery, vaccines, medical imaging, diagnostics, medical devices or tissue engineering, and regenerative medicine. [3][4][5][6][7][8] Indeed, it is expected that the approval of new nanotechnology-based medical products will grow exponentially over the next few years. 9,10 Current and future pharmacists, alongside doctors and other health care providers, are expected to be acquainted with basic knowledge and key concepts of nanotechnology, particularly those related with medical applications, to face professional demands and challenges.…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology Inclusion in Pharmaceutical Sciences Education in Portugal

Neves

2018

American Journal of Pharmaceutical Education

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Objective. To analyze the inclusion of nanotechnology in the curricula of Integrated Master's in Pharmaceutical Sciences programs in Portugal. Methods. Information regarding curricula (general notice and curricular unit description, objectives and syllabus) from national institutions was collected from their official websites or requested by e-mail, and analyzed for the occurrence of nanotechnology and related terms. A nanotechnology inclusion in curriculum (NIC) index was developed and used to rank each institution. Results. All institutions with available data (eight out of nine) offered nanotechnology in their curricula. Both basic and applied nanotechnology-related education were offered to students but mostly from a theoretical perspective. The NIC index provided a standardized tool for comparing the institutions' programs and highlighted differences according to the relative importance of the presence of nanotechnology and related terms in curricula. Conclusion. Portuguese institutions offering integrated master's programs in pharmaceutical sciences are including nanotechnology in their curricula. However, its implementation across all institutions remains weak and requires further strengthening to meet the requirements of this emerging field in health care practice.

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Nanotechnology in Advanced Medical Devices

Cited by 2 publications

References 90 publications

Investigation of Three-Dimensional Bacterial Adhesion Manner on Model Organic Surfaces Using Quartz Crystal Microbalance with Energy Dissipation Monitoring

Investigation of Three-Dimensional Bacterial Adhesion Manner on Model Organic Surfaces Using Quartz Crystal Microbalance with Energy Dissipation Monitoring

Nanotechnology Inclusion in Pharmaceutical Sciences Education in Portugal

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