Nanotechnology's application in Type 1 diabetes

Pan, Wen Harn; Zheng, Xueying; Chen, Guiyuan; Su, Lanhong; Luo, Sihui; Wang, Wei; Ye, Shandong; Weng, Jianping; Min, Yuanzeng

doi:10.1002/wnan.1645

Cited by 7 publications

(5 citation statements)

References 95 publications

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“…Several applications have emerged, such as cancer, cardiovascular disease, diabetes, neurodegenerative diseases, and infectious diseases. In infectious diseases, nanomedicine has applications in diagnosis as well as in therapy [13,38,[70][71][72][73]. More specifically, nanomedicine in the field of infectious diseases may aid in the diagnosis and treatment of bacterial, viral, parasitic, or mycobacterial disease [74][75][76][77][78][79].…”

Section: Principles Of Nanotechnologymentioning

confidence: 99%

Nanotechnology in the Diagnosis and Treatment of Antibiotic-Resistant Infections

Ioannou,

Baliou,

Samonis

2024

Antibiotics

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The development of antimicrobial resistance (AMR), along with the relative reduction in the production of new antimicrobials, significantly limits the therapeutic options in infectious diseases. Thus, novel treatments, especially in the current era, where AMR is increasing, are urgently needed. There are several ongoing studies on non-classical therapies for infectious diseases, such as bacteriophages, antimicrobial peptides, and nanotechnology, among others. Nanomaterials involve materials on the nanoscale that could be used in the diagnosis, treatment, and prevention of infectious diseases. This review provides an overview of the applications of nanotechnology in the diagnosis and treatment of infectious diseases from a clinician’s perspective, with a focus on pathogens with AMR. Applications of nanomaterials in diagnosis, by taking advantage of their electrochemical, optic, magnetic, and fluorescent properties, are described. Moreover, the potential of metallic or organic nanoparticles (NPs) in the treatment of infections is also addressed. Finally, the potential use of NPs in the development of safe and efficient vaccines is also reviewed. Further studies are needed to prove the safety and efficacy of NPs that would facilitate their approval by regulatory authorities for clinical use.

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Section: Principles Of Nanotechnologymentioning

confidence: 99%

Nanotechnology in the Diagnosis and Treatment of Antibiotic-Resistant Infections

Ioannou,

Baliou,

Samonis

2024

Antibiotics

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“…Besides, engineered programmed death-ligand 1 (PD-L1)-expressing platelets reverse new-onset T1D ( Zhang et al, 2020 ). Meantime, nanomaterials are used for the diagnosis and immunological imaging of T1D ( Pan et al, 2020 ). New technologies and methods may provide a variety of treatments for autoimmune diseases.…”

Section: Future Expectationmentioning

confidence: 99%

The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases

et al. 2021

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Interleukin-38 (IL-38), a new cytokine of interleukin-1 family (IL-1F), is expressed in the human heart, kidney, skin, etc. Recently, new evidence indicated that IL-38 is involved in the process of different autoimmune diseases. Autoimmune diseases are a cluster of diseases accompanied with tissue damage caused by autoimmune reactions, including rheumatoid arthritis (RA), psoriasis, etc. This review summarized the links between IL-38 and autoimmune diseases, as well as the latest knowledge about the function and regulatory mechanism of IL-38 in autoimmune diseases. Especially, this review focused on the differentiation of immune cells and explore future prospects, such as the application of IL-38 in new technologies. Understanding the function of IL-38 is helpful to shed light on the progress of autoimmune diseases.

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“…Many preclinical and clinical studies have investigated the multifactorial function of DCs during onset and progression of this autoimmune disease. While in vivo imaging has been employed for tracking DC migration in preclinical models and in the clinic [21][22][23], the kinetics of diabetogenic DCs homing to the pancreas and pLN are still not fully understood also due to only a limited number of studies applying these imaging methods to the longitudinal in vivo tracking of cells in diabetes models [24].…”

Section: Introductionmentioning

confidence: 99%

Fluorine MR Imaging Probes Dynamic Migratory Profiles of Perfluorocarbon-Loaded Dendritic Cells After Streptozotocin-Induced Inflammation

et al. 2022

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The pathogenesis of type 1 diabetes (T1D) involves presentation of islet-specific self-antigens by dendritic cells (DCs) to autoreactive T cells, resulting in the destruction of insulin-producing pancreatic beta cells. We aimed to study the dynamic homing of diabetes-prone DCs to the pancreas and nearby organs with and without induction of pancreatic stress in a T1D susceptible model of repeated streptozotocin (STZ) injection. Procedures: In vitro labeling of activated bone marrow-derived DCs (BMDCs) from NOD (Nonobese diabetes) mice was performed using zonyl perfluoro-15-crown-5-ether nanoparticles (ZPFCE-NPs). Internalization of particles was confirmed by confocal microscopy. Two groups of NOD.SCID (nonobese diabetic/severe combined immunodeficiency) mice with (induced by low dose STZ administration) or without pancreatic stress were compared. Diabetogenic BMDCs loaded with BDC2.5 mimotope were pre-labeled with ZPFCE-NPs and adoptively transferred into mice. Longitudinal in vivo fluorine MRI ( 19 F MRI) was performed 24 h, 36 h and 48 h after transfer of BMDCs. For ex vivo quantification of labeled cells, 19 F NMR and flow cytometry were performed on dissected tissues to validate in vivo 19 F MRI data. Results: In vitro flow cytometry and confocal microscopy confirmed high uptake of nanoparticles in BMDCs during the process of maturation. Migration/homing of activated and ZPFCE-NP-labeled BMDCs to different organs was monitored and quantified longitudinally, showing highest cell density in pancreas at 48-h time-point. Based on 19 F MRI, STZ induced mild inflammation in the pancreatic region, as indicated by high accumulation of ZPFCE-NP-labeled BMDCs in the pancreas when compared to the vehicle group. Pancreatic draining lymph nodes showed elevated homing of labeled BMDCs in the vehicle groups in contrast to the STZ group after 72 h. The effect of STZ was confirmed by increased blood glucose levels. Conclusion:We showed the potential of 19 F MRI for the non-invasive visualization and quantification of migrating immune cells in models for pancreatic inflammation after STZ administration. Without any intrinsic background signal, 19 F MRI serves as a highly specific imaging tool to study the migration of diabeticprone BMDCs in T1D models in vivo. This approach could particularly be of interest for the longitudinal assessment of established or novel anti-inflammatory therapeutic approaches in preclinical models.

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Nanotechnology's application in Type 1 diabetes

Cited by 7 publications

References 95 publications

Nanotechnology in the Diagnosis and Treatment of Antibiotic-Resistant Infections

Nanotechnology in the Diagnosis and Treatment of Antibiotic-Resistant Infections

The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases

Fluorine MR Imaging Probes Dynamic Migratory Profiles of Perfluorocarbon-Loaded Dendritic Cells After Streptozotocin-Induced Inflammation

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