Nanotherapeutics for solid organ transplantation: new kid on the block

Xu, Gang; Duan, Zhenyu; Luo, Qiang; Yang, Jiayin

doi:10.1016/j.ebiom.2023.104624

eBioMedicine

2023

DOI: 10.1016/j.ebiom.2023.104624

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Nanotherapeutics for solid organ transplantation: new kid on the block

Gang Xu

Zhenyu Duan

Qiang Luo

et al.

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2024

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Nanoparticle-assisted Targeting Delivery Technologies for Preventing Organ Rejection

Meng,

Fu,

Xie

et al. 2024

Transplantation

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Although organ transplantation is a life-saving medical procedure, the challenge of posttransplant rejection necessitates safe and effective immune modulation strategies. Nanodelivery approaches may have the potential to overcome the limitations of small-molecule immunosuppressive drugs, achieving efficacious treatment options for transplant tolerance without compromising overall host immunity. This review highlights recent advances in biomaterial-assisted formulations and technologies for targeted nanodrug delivery with transplant organ- or immune cell–level precision for treating graft rejection after transplantation. We provide an overview of the mechanism of transplantation rejection, current clinically approved immunosuppressive drugs, and their relevant limitations. Finally, we discuss the targeting principles and advantages of organ- and immune cell–specific delivery technologies. The development of biomaterial-assisted novel therapeutic strategies holds considerable promise for treating organ rejection and clinical translation.

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Nanoparticle-assisted Targeting Delivery Technologies for Preventing Organ Rejection

Meng,

Fu,

Xie

et al. 2024

Transplantation

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show abstract

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Nanotherapeutics for solid organ transplantation: new kid on the block

Cited by 1 publication

References 10 publications

Nanoparticle-assisted Targeting Delivery Technologies for Preventing Organ Rejection

Nanoparticle-assisted Targeting Delivery Technologies for Preventing Organ Rejection

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