Nanovesicular Transfersomes for Enhanced Systemic Delivery of Telmisartan

Amin, Saima; Sarfenejad, Ahmad; Ahmad, Javed; Kohli, Kanchan; Mir, Showkat R.

doi:10.1166/asem.2013.1288

Cited by 20 publications

(5 citation statements)

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“…After dilution with methanol, the amount of RT in each extract was determined using a UV spectrophotometer (λmax 325 nm). Each analysis was performed in triplicate, and the content uniformity of RT was assessed as the average content in terms of percentage [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

Nanoemulgel for Improved Topical Delivery of Retinyl Palmitate: Formulation Design and Stability Evaluation

Algahtani

Ahmad

2020

Nanomaterials

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Retinyl palmitate is a vitamin A ester belonging to the family of endogenous natural retinoid and used to treat various skin disorders like acne, skin aging, wrinkles, and dark spots, as well as to protect against psoriasis. Despite the known therapeutic benefits of retinyl palmitate, the conventional topical delivery of retinyl palmitate commonly associated with adverse reactions such as skin irritation, redness, excessive peeling, and dryness. Therefore, the current study aims to encapsulate the retinyl palmitate in nanoemulsion then incorporate it into a hydrogel system to improve the topical delivery and stability. Low-energy emulsification method was used for the nano-encapsulation of retinyl palmitate. The phase behavior study was used for the investigation and the optimization of the formulation. The droplet size of the optimized nanoemulsion was in nano dimension (16.71 nm) with low polydispersity index (PdI) (0.015), negative zeta potential (−20.6 mV). It demonstrated the influence of vortexing on droplet size and PdI during nanoemulsion preparation. The retinyl palmitate loaded nanoemulgel delivery system exhibited significant improvement (p < 0.05) in skin permeability after topical application. Employment of the nano-encapsulation approach afterward dispersion into hydrogel system for the development of a topical delivery system of retinyl palmitate resulted in improvement in its UV and storage stability as well.

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Section: Methodsmentioning

confidence: 99%

Nanoemulgel for Improved Topical Delivery of Retinyl Palmitate: Formulation Design and Stability Evaluation

Algahtani

Ahmad

2020

Nanomaterials

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“…An obvious effort has been made to transfersome flexible carriers to enhance entrapment, drug load, size, and surface malleability that can efficiently penetrate, partition, and permeate the skin barrier. 8 Ethosomal systems are non-irritant vesicles, easily prepared, composed mainly of phospholipids and ethanol, compounds commonly found in pharmaceutical preparations. These carriers are highly efficient for the delivery of molecules with various lipophilicities through the skin, in vitro and in vivo in animal and clinical studies.…”

Section: Introductionmentioning

confidence: 99%

Transdermal Delivery of Telmisartan: Formulation, in vitro, ex vivo, Iontophoretic Permeation Enhancement and Comparative Pharmacokinetic Study in Rats

Teaima¹,

Abdelmonem²,

Adel

et al. 2021

DDDT

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“…Further, different dilutions were prepared with PBS (pH 7.4) and the amount of drug was measured in U.V.-Vis spectrophotometer at 340 nm. The test was performed thrice and the mean values were used to calculate data [30].…”

Section: Drug Contentmentioning

confidence: 99%

Formulation and Biological Evaluation of Quorum Sensing Inhibitor-Based Nanoemulsion against Resistant Pseudomonal Infections

Bhardwaj¹,

Bhatia²

2023

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Antimicrobial resistance has raised a serious concern due to the lack of therapeutics to control pathogenic infections. Pseudomonas aeruginosa is considered a multidrug-resistant pathogen and a leading cause of hospital-acquired infections. Anti-virulence approach mainly focuses on targeting bacterial virulence despite its growth and proves effective against such drug-resistant pathogens. In this study, we select a novel flavonoid compound, 7,8-dihydroxyflavone (DHF), which has been reported as a quorum sensing inhibitor (QSI) of P. aeruginosa, performed its in-silico studies to observe its binding affinity and potential interactions with the target protein (2UV0) and further developed it as a nano drug formulation (DHF-NF), and performed its in-vitro and in-vivo evaluation. The prepared DHF-NF was examined for its efficacy in the prevention of wound-associated surface infections of P. aeruginosa in rats. The DHF-NF was prepared by using homogenization and examined for several physical parameters. The prepared DHF-NF had a spherical shape and smooth topology. The microbiological assays demonstrated the inhibitory potential of DHF-NF in a dose-dependent manner. The histological analysis of Pseudomonas infected tissue of rat skin showed significant activity in animal group treated with DHF-NF as compared to control groups. The microbiological and in-vivo evaluation results revealed that the compound, DHF, showed strong inhibitory potential and suggest that the DHF-NF could be utilized as novel anti-QS and anti-biofilm therapeutics against Pseudomonal surface infections.

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Nanovesicular Transfersomes for Enhanced Systemic Delivery of Telmisartan

Cited by 20 publications

References 0 publications

Nanoemulgel for Improved Topical Delivery of Retinyl Palmitate: Formulation Design and Stability Evaluation

Nanoemulgel for Improved Topical Delivery of Retinyl Palmitate: Formulation Design and Stability Evaluation

Transdermal Delivery of Telmisartan: Formulation, in vitro, ex vivo, Iontophoretic Permeation Enhancement and Comparative Pharmacokinetic Study in Rats

Formulation and Biological Evaluation of Quorum Sensing Inhibitor-Based Nanoemulsion against Resistant Pseudomonal Infections

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