Nanozyme: new horizons for responsive biomedical applications

Jiang, Dawei; Ni, Dalong; Rosenkrans, Zachary T.; Huang, Peng; Yan, Xiyun; Cai, Weibo

doi:10.1039/c8cs00718g

Cited by 1,329 publications

(799 citation statements)

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“…Therefore, the combined therapy accompanied with modulating TME is vital for ablating primary tumor and preventing cancer metastasis . Recently, nanozymes based on the catalytic reaction of multivalent metal ion (such as Fe 2+/3+ , Cu 1+/2+ , Mn 2+/4+ ), which mimicked the functions of natural enzymes, had shown remarkable effect in modulating TME and thus enhancing therapeutic effect . For example, Zhang and co‐workers fabricated MnFe 2 O 4 @MOF nanoplatform with catalase (CAT)‐like and glutathione peroxidase‐like activities, which could persist modulating TME by triggering O 2 generation and GSH depletion, resulting in enhanced photodynamic treatment outcomes .…”

Section: Methodsmentioning

confidence: 99%

A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu₂MoS₄ for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy

et al. 2019

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The unique tumor microenvironment (TME) facilitates cancer proliferation and metastasis, and it is hard to cure cancer completely via monotherapy. Herein, a multifunctional cascade bioreactor based on hollow mesoporous Cu2MoS4 (CMS) loaded with glucose oxidase (GOx) is constructed for synergetic cancer therapy by chemo‐dynamic therapy (CDT)/starvation therapy/phototherapy/immunotherapy. The CMS harboring multivalent elements (Cu1+/2+, Mo4+/6+) exhibit Fenton‐like, glutathione (GSH) peroxidase‐like and catalase‐like activity. Once internalized into the tumor, CMS could generate ·OH for CDT via Fenton‐like reaction and deplete overexpressed GSH in TME to alleviate antioxidant capability of the tumors. Moreover, under hypoxia TME, the catalase‐like CMS could react with endogenous H2O2 to generate O2 for activating the catalyzed oxidation of glucose by GOx for starvation therapy accompanied with the regeneration of H2O2. The regenerated H2O2 can devote to Fenton‐like reaction for realizing GOx‐catalysis‐enhanced CDT. Meanwhile, the CMS under 1064 nm laser irradiation shows remarkable tumor‐killing ability by phototherapy due to its excellent photothermal conversion efficiency (η = 63.3%) and cytotoxic superoxide anion (·O2−) generation performance. More importantly, the PEGylated CMS@GOx‐based synergistic therapy combined with checkpoint blockade therapy could elicit robust immune responses for both effectively ablating primary tumors and inhibiting cancer metastasis.

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Section: Methodsmentioning

confidence: 99%

A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu₂MoS₄ for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy

et al. 2019

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“…Nanomaterials with enzyme-like characteristics (nanozymes) have become promising alternatives to traditional enzymes and have the unique advantage of bridging nanotechnology and biology [2,3]. Many types of nanozymes have been reported and applied in the catalysis of a broad range of reactions [4][5][6]. However, the activity and specificity of nanozymes still differ substantially from those of natural enzymes.…”

Section: Introductionmentioning

confidence: 99%

Revealing the Intrinsic Peroxidase-Like Catalytic Mechanism of Heterogeneous Single-Atom Co–MoS2

et al. 2019

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HIGHLIGHTS• Single-atom Co-MoS 2 (SA Co-MoS 2 ) is prepared successfully to serve as a proof-of-concept nanozyme model, which exhibits peroxidase-like performance comparable to that of natural enzymes.• The different mechanisms between the single-atom metal center and the support are investigated experimentally and theoretically.ABSTRACT The single-atom nanozyme is a new concept and has tremendous prospects to become a next-generation nanozyme. However, few studies have been carried out to elucidate the intrinsic mechanisms for both the single atoms and the supports in single-atom nanozymes. Herein, the heterogeneous single-atom Co-MoS 2 (SA Co-MoS 2 ) is demonstrated to have excellent potential as a high-performance peroxidase mimic. Because of the well-defined structure of SA Co-MoS 2 , its peroxidase-like mechanism is extensively interpreted through experimental and theoretical studies. Due to the different adsorption energies of substrates on different parts of SA Co-MoS 2 in the peroxidase-like reaction, SA Co favors electron transfer mechanisms, while MoS 2 relies on Fenton-like reactions. The different catalytic pathways provide an intrinsic understanding of the remarkable performance of SA Co-MoS 2 . The present study not only develops a new kind of single-atom catalyst (SAC) as an elegant platform for understanding the enzyme-like activities of heterogeneous nanomaterials but also facilitates the novel application of SACs in biocatalysis.

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“…In cancer diagnosis and therapy, nanozymes have received great attention. Nanozymes can be remotely controlled by different stimuli such as magnetic field, light, ultrasound, and heat [98]. These above stimuli factors can be applied for improving the diagnostic and therapeutic efficacies of different diseases in biomedical applications.…”

Section: Nanozymes In Cancer Therapymentioning

confidence: 99%

Progress and Trend on the Regulation Methods for Nanozyme Activity and Its Application

et al. 2019

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Natural enzymes, such as biocatalysts, are widely used in biosensors, medicine and health, the environmental field, and other fields. However, it is easy for natural enzymes to lose catalytic activity due to their intrinsic shortcomings including a high purification cost, insufficient stability, and difficulties of recycling, which limit their practical applications. The unexpected discovery of the Fe3O4 nanozyme in 2007 has given rise to tremendous efforts for developing natural enzyme substitutes. Nanozymes, which are nanomaterials with enzyme-mimetic catalytic activity, can serve as ideal candidates for artificial mimic enzymes. Nanozymes possess superiorities due to their low cost, high stability, and easy preparation. Although great progress has been made in the development of nanozymes, the catalytic efficiency of existing nanozymes is relatively low compared with natural enzymes. It is still a challenging task to develop nanozymes with a precise regulation of catalytic activity. This review summarizes the classification and various strategies for modulating the activity as well as research progress in the different application fields of nanozymes. Typical examples of the recent research process of nanozymes will be presented and critically discussed.

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Nanozyme: new horizons for responsive biomedical applications

Abstract: Nanozymes are nanomaterial-based artificial enzymes.

Cited by 1,329 publications

References 50 publications

A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu₂MoS₄ for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy

A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu₂MoS₄ for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy

Revealing the Intrinsic Peroxidase-Like Catalytic Mechanism of Heterogeneous Single-Atom Co–MoS2

Progress and Trend on the Regulation Methods for Nanozyme Activity and Its Application

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Nanozyme: new horizons for responsive biomedical applications

Abstract: Nanozymes are nanomaterial-based artificial enzymes.

Cited by 1,329 publications

References 50 publications

A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu2MoS4 for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy

A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu2MoS4 for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy

Revealing the Intrinsic Peroxidase-Like Catalytic Mechanism of Heterogeneous Single-Atom Co–MoS2

Progress and Trend on the Regulation Methods for Nanozyme Activity and Its Application

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A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu₂MoS₄ for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy

A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu₂MoS₄ for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy