Nanozymes for nanohealthcare

Zhang, Yihong; Wei, Gen; Liu, Wanling; Li, Tong; Wang, Yuting; Zhou, Min; Liu, Yufeng; Wang, Xiaoyu; Wei, Hui

doi:10.1038/s43586-024-00315-5

Cited by 31 publications

(1 citation statement)

References 191 publications

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“…Combining the advantages of nanomaterials and natural enzymes, artificial nanozymes have emerged as promising candidates in combating bacterial infections. − Unlike natural enzymes, nanozymes are suitable for large-scale production, have adjustable enzyme-like activity, low production costs, and high environmental stability. , So far, numerous nanozymes have been reported to exhibit good antimicrobial properties, including metal oxides and metal sulfides, , precious metals, , quantum dots, , MOFs, , metal composites, , and single atom materials. − However, complex design, relatively low bactericidal activity, and potential toxicity to normal cells or tissues still hinder their practical use. For example, Wang et al .…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticle-Immobilized Schiff-Base Macrocycles as Nanozymes with Peroxidase Mimic Activity for Antibacterial Films

Wang,

Redshaw,

Zhao

et al. 2024

ACS Appl. Nano Mater.

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The development of nanozymes has emerged as a promising pathway for combating bacterial infections. In this work, Ag/Schiff base nanozymes are obtained through the in situ reduction method on [2 + 3] Schiff base macrocycles using ecofriendly reductant α-tocopherol. The silver prepared was found to be nanoscale by TEM, and Ag NPs grew and dispersed uniformly on the surface of the Schiff base macrocycle due to the abundance of the C�N double bonds. The peroxidase-like catalytic activity of the Ag/Schiff base was evaluated toward 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of H 2 O 2 , and the K m values of 0.350 and 0.090 mM confirm the strong affinity of Ag/Schiff base for H 2 O 2 and TMB. Moreover, the nanozyme exhibited good antibacterial properties against Streptococcus sanguinis, Pseudomonas aeruginosa, and Staphylococcus aureus, and in vivo tests confirmed that the Ag/Schiff base had negligible biotoxicity. Benefiting from the good antimicrobial and biosafety properties, the nanozymes were explored to prepare antibacterial films, and the bacterial inhibition zones demonstrated that the introduction of the Ag/Schiff base could prevent the growth of bacteria.

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Section: Introductionmentioning

confidence: 99%

Silver Nanoparticle-Immobilized Schiff-Base Macrocycles as Nanozymes with Peroxidase Mimic Activity for Antibacterial Films

Wang,

Redshaw,

Zhao

et al. 2024

ACS Appl. Nano Mater.

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Nanozyme‐Shelled Microcapsules for Targeting Biofilm Infections in Confined Spaces

Tran,

Jaruchotiratanasakul,

Xiang

et al. 2024

Adv Healthcare Materials

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Bacterial infections in irregular and branched confinements pose significant therapeutic challenges. Despite their high antimicrobial efficacy, enzyme‐mimicking nanoparticles (nanozymes) face difficulties in achieving localized catalysis at distant infection sites within confined spaces. Incorporating nanozymes into microrobots enables the delivery of catalytic agents to hard‐to‐reach areas, but poor nanoparticle dispersibility and distribution during fabrication hinder their catalytic performance. To address these challenges, a nanozyme‐shelled microrobotic platform is introduced using magnetic microcapsules with collective and adaptive mobility for automated navigation and localized catalysis within complex confinements. Using double emulsions produced from microfluidics as templates, iron oxide and silica nanoparticles are assembled into 100‐µm microcapsules, which self‐organize into multi‐unit, millimeter‐size assemblies under rotating magnetic fields. These microcapsules exhibit high peroxidase‐like activity, efficiently catalyzing hydrogen peroxide to generate reactive oxygen species (ROS). Notably, microcapsule assemblies display remarkable collective navigation within arched and branched confinements, reaching the targeted apical regions of the tooth canal with high accuracy. Furthermore, these nanozyme‐shelled microrobots perform rapid catalysis in situ and effectively kill biofilms on contact via ROS generation, enabling localized antibiofilm action. This study demonstrates a facile method of integrating nanozymes onto a versatile microrobotic platform to address current needs for targeted therapeutic catalysis in complex and confined microenvironments.

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Smart Bioorthogonal Nanozymes: From Rational Design to Appropriate Bioapplications

Zhang,

Zhu,

Ren

et al. 2024

Advanced Materials

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Bioorthogonal chemistry has provided an elaborate arsenal to manipulate native biological processes in living systems. As the great advancement of nanotechnology in recent years, bioorthogonal nanozymes are innovated to tackle the challenges that emerged in practical biomedical applications. Bioorthogonal nanozymes are uniquely positioned owing to their advantages of high customizability and tunability, as well as good adaptability to biological systems, which bring exciting opportunities for biomedical applications. More intriguingly, the great advancement in nanotechnology offers an exciting opportunity for innovating bioorthogonal catalytic materials. In this comprehensive review, the significant progresses of bioorthogonal nanozymes are discussed with both spatiotemporal controllability and high performance in living systems, and highlight their design principles and recent rapid applications. The remaining challenges and future perspectives are then outlined along this thriving field. It is expected that this review will inspire and promote the design of novel bioorthogonal nanozymes, and facilitate their clinical translation.

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Nanozymes for nanohealthcare

Cited by 31 publications

References 191 publications

Silver Nanoparticle-Immobilized Schiff-Base Macrocycles as Nanozymes with Peroxidase Mimic Activity for Antibacterial Films

Silver Nanoparticle-Immobilized Schiff-Base Macrocycles as Nanozymes with Peroxidase Mimic Activity for Antibacterial Films

Nanozyme‐Shelled Microcapsules for Targeting Biofilm Infections in Confined Spaces

Smart Bioorthogonal Nanozymes: From Rational Design to Appropriate Bioapplications

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