Nanozymes with versatile redox capabilities inspired in metalloenzymes

López-Domene, Rocío; Kumar, Krishan; Barcelon, Jose Eduardo; Guedes, Gabriela; Beloqui, Ana; Cortajarena, Aitziber L.

doi:10.1039/d3nr03443g

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…In addition to idiographic substances, the detection/visualization of environmental variation, specific interaction, and essential process is also an important aspect [98,99]. Moreover, through proper design, synergistic interactions with boosted therapeutic performances are an interesting research direction [100][101][102][103]. The understanding of Au NCs' potential in treating newly discovered diseases may make the world better [104,105].…”

Section: Discussionmentioning

confidence: 99%

Recent Advances in Gold Nanocluster-Based Biosensing and Therapy: A Review

Yang,

Hou,

Wei

et al. 2024

Molecules

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Gold nanoclusters (Au NCs) with bright emission and unique chemical reactivity characters have been widely applied for optical sensing and imaging. With a combination of surface modifications, effective therapeutic treatments of tumors are realized. In this review, we summarize the recently adopted biosensing and therapy events based on Au NCs. Homogeneous and fluorometric biosensing systems toward various targets, including ions, small molecules, reactive oxygen species, biomacromolecules, cancer cells, and bacteria, in vitro and in vivo, are presented by turn-off, turn-on, and ratiometric tactics. The therapy applications are concluded in three aspects: photodynamic therapy, photothermal therapy, and as a drug carrier. The basic mechanisms and performances of these systems are introduced. Finally, this review highlights the challenges and future trend of Au NC-based biosensing and therapy systems.

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Section: Discussionmentioning

confidence: 99%

Recent Advances in Gold Nanocluster-Based Biosensing and Therapy: A Review

Yang,

Hou,

Wei

et al. 2024

Molecules

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Biotemplated Platinum Nanozymes: Synthesis, Catalytic Regulation and Biomedical Applications

Lei,

Yu,

Yang

et al. 2024

ChemBioChem

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Platinum (Pt) nanozymes with multiple intrinsic enzyme‐mimicking activities have attracted extensive attention in biomedical fields due to their high catalytic activity, ease of modification, and convenient storage. However, the Pt nanozymes synthesized by the traditional method often suffer from uncontrollable morphology and poor stability under physicochemical conditions, resulting in unsatisfactory catalytic behavior in practical applications. To optimize the catalytic ability, biological templates have been introduced recently, which can guide the deposition of platinum ions on their surface to form specific morphologies and then stabilize the resulting Pt nanozymes. Given the promising potential of biotemplated Pt nanozymes in practical applications, it is essential to conduct a systematic and comprehensive review to summarize their recent research progress. In this review, we first categorize the biological templates and discussed the mechanisms as well as characteristics of each type of biotemplate in directing the growth of Pt nanozyme. Factors that impact the growth of biotemplated Pt nanozymes are then analyzed, followed by summarizing their biomedical application. Finally, the challenges and opportunities in this field are outlined. This review article aims to provide theoretical guidance for developing Pt nanozymes with robust functionalities in biomedical applications.

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