Naphthalimide-based a highly selective two-photon fluorescent probe for imaging of hydrogen sulfide in living cells and inflamed tissue of mouse model

Ou, Pinghua; Wang, Yali; Hao, Cong; Peng, Yongbo; Zhou, Liyi

doi:10.1016/j.saa.2020.118886

Cited by 11 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 45 ] Furthermore, according to the comparison of DC‐HS with other reported fluorescent probes in the literature (Table 1), the LOD of DC‐HS for H 2 S was lower than other published probes. [ 45–49 ] From these findings, we inferred that probe DC‐HS displayed readily detectable changes in its fluorescence signature at nanomolar concentrations of the H 2 S level.…”

Section: Resultsmentioning

confidence: 92%

Novel fluorescent probe based on dicoumarin for detection of hydrogen sulfide in real samples

Hong

Cheng

Zhong

et al. 2023

J Chinese Chemical Soc

View full text Add to dashboard Cite

A novel dicoumarin‐derived hydrogen sulfide (H2S) selective fluorescent “turn‐on” probe 3‐(2,4‐dinitrobenzenesulfonate)‐dicoumarin (DC‐HS) created by covalent bonding between the 2,4‐dinitrobenzenesulfonyl (DNBS) and the 3‐hydroxy‐dicoumarin (DC‐OH) units. Upon the addition of H2S, the probe DC‐HS solution's fluorescence significantly increased, and its appearance is changed from practically colorless to brilliant yellow. Probe DC‐HS also showed significant fluorescence amplification that was quantitatively detectable in the concentration range of 0–1.5 μM and had a low detection limit or limit of detection of 0.2 nM. Moreover, with a high recovery rate and excellent accuracy, the developed fluorescent molecule was used successfully for the analysis of H2S in red wine samples.

show abstract

Section: Resultsmentioning

confidence: 92%

Novel fluorescent probe based on dicoumarin for detection of hydrogen sulfide in real samples

Hong

Cheng

Zhong

et al. 2023

J Chinese Chemical Soc

View full text Add to dashboard Cite

show abstract

“…Probe 317 showed poor selectivity over thiols, but this selectivity was moderately improved in 318 . Peng reported a naphthalimide amine version in 319 (NP-H 2 S), which relies on quenching of the DNP group to modulate the naphthalimide fluorescence . This probe showed good selectivity for H 2 S over other analytes, although only 100 μM of thiols were tested.…”

Section: Electrophilic H2s Probesmentioning

confidence: 99%

Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species

Fosnacht,

Pluth

2024

Chem. Rev.

View full text Add to dashboard Cite

Hydrogen sulfide (H 2 S) is not only a well-established toxic gas but also an important small molecule bioregulator in all kingdoms of life. In contemporary biology, H 2 S is often classified as a "gasotransmitter," meaning that it is an endogenously produced membrane permeable gas that carries out essential cellular processes. Fluorescent probes for H 2 S and related reactive sulfur species (RSS) detection provide an important cornerstone for investigating the multifaceted roles of these important small molecules in complex biological systems. A now common approach to develop such tools is to develop "activitybased probes" that couple a specific H 2 S-mediated chemical reaction to a fluorescent output. This Review covers the different types of such probes and also highlights the chemical mechanisms by which each probe type is activated by specific RSS. Common examples include reduction of oxidized nitrogen motifs, disulfide exchange, electrophilic reactions, metal precipitation, and metal coordination. In addition, we also outline complementary activity-based probes for imaging reductant-labile and sulfane sulfur species, including persulfides and polysulfides. For probes highlighted in this Review, we focus on small molecule systems with demonstrated compatibility in cellular systems or related applications. Building from breadth of reported activity-based strategies and application, we also highlight key unmet challenges and future opportunities for advancing activity-based probes for H 2 S and related RSS.

show abstract

“…S1: Comparison of HND for the detection of H2S. References [43][44][45] are cited in Supplementary Materials.…”

Section: Supplementary Materialsmentioning

confidence: 99%

An Aggregation-Induced Fluorescence Probe for Detection H2S and Its Application in Cell Imaging

Tang,

Zhang,

Wang

et al. 2024

Molecules

View full text Add to dashboard Cite

Monitoring hydrogen sulfide (H2S) in living organisms is very important because H2S acts as a regulator in many physiological and pathological processes. Upregulation of endogenous H2S concentration has been shown to be closely related to the occurrence and development of tumors, atherosclerosis, neurodegenerative diseases and diabetes. Herin, a novel fluorescent probe HND with aggregation-induced emission was designed. Impressively, HND exhibited a high selectivity, fast response (1 min) and low detection limit (0.61 μM) for H2S in PBS buffer (10 mM, pH = 7.42). Moreover, the reaction mechanism between HND and H2S was conducted by Job’s plot, HR-MS, and DFT. In particular, HND was successfully employed to detect H2S in HeLa cells.

show abstract

Naphthalimide-based a highly selective two-photon fluorescent probe for imaging of hydrogen sulfide in living cells and inflamed tissue of mouse model

Cited by 11 publications

References 17 publications

Novel fluorescent probe based on dicoumarin for detection of hydrogen sulfide in real samples

Novel fluorescent probe based on dicoumarin for detection of hydrogen sulfide in real samples

Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species

An Aggregation-Induced Fluorescence Probe for Detection H2S and Its Application in Cell Imaging

Contact Info

Product

Resources

About