Naphthoylhydrazones: coordination to metal ions and biological screening

Abstract

VIVO, CuII and ZnII complexes from three new naphthoylhydrazones were screened towards their ability to bind albumin and their cytotoxicity.

New VIV, VIVO, VVO, and VVO2 Systems: Exploring their Interconversion in Solution, Protein Interactions, and Cytotoxicity

“…The bianionic ligands (L 2 ) 2– and (L 3 ) 2– bind V IV O 2+ in a tridentate fashion with the (O – , N, O – ) donors on the equatorial plane, the remaining position being occupied probably by a solvent molecule. The spin Hamiltonian parameters are comparable to those measured for other 1:1 V IV O species formed by tridentate ligands with a similar coordination mode. ,,,, …”

Assessment of the biological effect of metal ions and their complexes using Allium cepa and Artemia salina assays: a possible environmental implementation of biological inorganic chemistry

“…A. salina larvae were incubated with 0.1 mg/mL of naphthoyl hydrazonoate copper complexes of formulae Cu(L i ) 2 , (3-hydroxyl-2-naphthoylhydrazones containing pyrrole (HL 1 ), furane (HL 2 ) and thiophene (HL 3 ) moieties) ( 74–76 ) for 24 h. The percentage of dead organisms upon their incubation with the samples 74–76 is 77.4, 92.8 and 43.1%, respectively (Table 2 ) [ 48 ].…”

Synthesis of Co(II), Ni(II) and Zn(II) Metal Complexes Derived from a Hydrazone Schiff Base: Electrochemical Behavior and Comprehensive Biological Studies

“…Therefore, several researchers are focusing on the synthesis of these class of compounds as target structures to evaluate their biological activities. [4] Metal complexes of hydrazones showed some degree of antibacterial, antifungal and antitumor activities. [5,6] Literature reveals that Schiff bases containing the combination of N, S and N, O donors efficiently coordinate to transition metal ions.…”

“…Hydrazones possess azomethine moiety, which constitute an important class of compounds for new drug development. Therefore, several researchers are focusing on the synthesis of these class of compounds as target structures to evaluate their biological activities [4] . Metal complexes of hydrazones showed some degree of antibacterial, antifungal and antitumor activities [5,6] .…”