Naphthyridines. Structure, physicochemical properties and general methods of synthesis

The first synthesis of furazano[3,4‐b][1,6]naphthyridines

“…6.5 Hz) for the coupling constants J H(7),H (8) and a carbonyl ( 13 C NMR) resonance for such constructs at 173.6 ppm. The spectral assignment of the pyridone form agreed with the literature [25][26][27].…”

“…Much greater attention has been directed towards the synthesis of benzo-and pyrido-annelated 1,6-naphthyridine ring systems probably as a consequence of the ready availability of suitable precursors [8][9][10]. At the same time only two azole[h]annelated ring systems have been reported, namely oxazolo [4,5-f] [1,6]naphthyridine [11] and pyrazolo [3,4-h] [1,6]naphthyridine [12][13][14].…”

“…Considerable efforts have been directed toward the synthesis of 1.6-naphthyridine derivatives. A number of methods for their preparations have been developed and are well covered in the literature by some excellent reviews [6][7][8][9][10].…”

Synthesis and Antiparasitic Activity Against Trypanosoma cruzi and Leishmania amazonensis of Chlorinated 1,7- and 1,8-Naphthyridines

“…This class of compounds is currently the topic of studies conducted in several fields. For instance, synthetic naphthyridines have been employed as antimalarial, antiviral and antitumoral agents [18]. Therefore, the diverse range of biological activities of naphthyridine derivatives has stimulated considerable interest in their synthesis.…”

Three-Component One-Pot Synthesis of Novel Benzo[b]1,8-naphthyridines Catalyzed by Bismuth(III) Chloride

“…Functionalized naphthyridines have found applications as pharmaceuticals, fungicides, bactericides, herbicides, and insecticides as well as useful synthetic blocks in the preparation of several alkaloids [3][4][5][6]. Many syntheses of naphthyridines are known, but due to their importance, the development of new synthetic approaches remains an active research area [7,8].…”