Naples Prognostic Score as a novel prognostic prediction tool in video-assisted thoracoscopic surgery for early-stage lung cancer: a propensity score matching study

Li, Shuangjiang; Wang, Hongyu; Zhang, Yang; Zhao, Liang; Lv, Wenyu; Du, Heng; Che, Guowei; Liu, Lunxu

doi:10.1007/s00464-020-07851-7

Cited by 30 publications

(44 citation statements)

References 25 publications

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“…The NLR and LMR were defined as the ratio of neutrophil count to lymphocyte count and lymphocyte count to monocyte count, respectively. The NPS was composed of the following four serum indicators (ALB, TC, NLR and LMR) according to the previous study (11)(12)(13)(14)(15)(16)(17)(18). ESCC has its own characteristics, and patients with ESCC are mostly malnourished, so the above hematological indicators may be different from other cancers.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the results revealed that NPS was more sensitive than other conventional prognostic scores for OS prediction in patients with metastatic CRC according to the time-dependent ROC analysis. Since then, NPS has been further reported in patients with various cancers (13)(14)(15)(16)(17). We summarized published articles regarding the association between NPS and prognosis in cancers (Table 8).…”

Section: Discussionmentioning

confidence: 99%

“…According to the analyses with time-dependent receiver operating characteristic (ROC) curves, moreover, the study revealed that NPS was more sensitive than other conventional prognostic scores for OS prediction in patients with metastatic CRC. Since then, NPS has been further reported in patients with resected endometrial cancer, gastric cancer, early-stage lung cancer, osteosarcoma, and resected pancreatic cancer (13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

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Naples Prognostic Score: A Novel Prognostic Score in Predicting Cancer-Specific Survival in Patients With Resected Esophageal Squamous Cell Carcinoma

et al. 2021

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BackgroundNaples prognostic score (NPS) serves as a new prognostic index based on nutritional and inflammatory status in recent years. The aim of the current study was to explore the prognostic effect of NPS and to develop and validate a reliable nomogram based on NPS for individual cancer-specific survival (CSS) prediction in patients with resected ESCC without neoadjuvant therapy.MethodsThe clinical data for 287 (Jan. 2010 to Jun. 2012, Training sets) and 118 (Jan. 2015 to Dec 2015, Validation sets) consecutive resected ESCC cases were retrospectively analyzed. Two NPS models based on the different cut-off values of parameters were compared. Cut-off values in model 1 were derived from previous published studies, while cut-off values in model 2 were obtained in this study based on receiver operating characteristic (ROC) curves. The relationships between NPS and clinical characteristics and CSS were analyzed. The prediction model of nomogram was developed with independent prognostic factors in the training sets and was validated in the validation sets.ResultsThe 5-year CSS for NPS 0, 1 and 2 were 61.9%, 34.6% and 13.4% in model 1 and 75.0%, 42.4% and 13.0% in model 2, respectively (P<0.001). Subgroup analyses revealed that NPS was also significantly associated with CSS in both model 1 and model 2 in different TNM stages. Multivariate analyses revealed that NPS was an independent prognostic marker regarding CSS in patients with resected ESCC (P<0.001). A predictive nomogram based on NPS was established and validated. The C-indexes of the nomogram in the training sets and validation sets were 0.68 and 0.72 in model 1 and 0.69 and 0.73 in model 2, respectively. These results confirmed that NPS-based nomogram was a more accurate and effective tool for predicting CSS in patients with resected ESCC.ConclusionThe current study confirmed that NPS was still a useful independent prognostic score in patients with resected ESCC. The NPS-based nomogram was successfully developed and validated, which may contribute to individual CSS prediction for resected ESCC patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Naples Prognostic Score: A Novel Prognostic Score in Predicting Cancer-Specific Survival in Patients With Resected Esophageal Squamous Cell Carcinoma

et al. 2021

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“…Non-small-cell lung cancer (NSCLC) is one of the worldwide leading causes of deaths from solid malignancy. [1][2][3][4][5][6] Up to date, surgical resection has been generally considered as the most preferred treatment option for resectable early-stage NSCLC. However, despite dramatic advances in elective therapeutic techniques, clinical prognosis of NSCLC, reaching at a poor 5-year survival rate around 15%-18%, still remains frustrating.…”

Section: Introductionmentioning

confidence: 99%

Gamma-Glutamyl Transpeptidase to Platelet Ratio Is a Novel and Independent Prognostic Marker for Resectable Lung Cancer: A Propensity Score Matching Study

Zhao

Jiang

et al. 2021

ATCS

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Background: We report this propensity score matching (PSM) analysis to assess prognostic roles of preoperative gamma-glutamyl transpeptidase to platelet ratio (GPR) in video-assisted thoracoscopic (VATS) lobectomy for stage I-II non-small-cell lung cancer (NSCLC). Methods: The PSM-based study conducted on our single-center prospectively collected database from January 2014 to August 2015 provided Kaplan-Meier survival analyses using the log-rank test to discriminate differences in overall survival (OS) and disease-free survival (DFS) between patients stratified by preoperative GPR. Results: Our study includes 379 patients diagnosed with operable primary stage I-II NSCLC. A GPR value at 0.16 was recognized as the optimal cutoff point for prognostic prediction. Both OS and DFS of patients with GPR ≥0.16 were significantly shortened when compared to those of patients with GPR <0.16. Patients with GPR ≥0.16 had significantly lower 5-year rates of OS and DFS than those of patients with GPR <0.16 (P <0.001). Significant associations between GPR and unfavorable survival still are validated in the PSM analysis. Multivariable Cox regression models on both the entire cohort and the PSM cohort consistently demonstrated that an elevated preoperative GPR could be an independent prognostic marker for both OS and DFS of resectable NSCLC. Conclusions: GPR may be an effective and noninvasive prognostic biomarker in VATS lobectomy for surgically resectable NSCLC.

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“…Recently, Galizia et al first reported that the Naples prognostic score (NPS) was the novel rating system formulated according to serum Alb level, total cholesterol (TC) level, NLR along with LMR, which reflected the nutritional and systemic inflammatory statuses in cancer patients (13). Typically, the NPS is strongly associated with the prognostic outcomes for colorectal cancer (CRC), pancreatic cancer, lung cancer, gastric cancer, and osteosarcoma (13)(14)(15)(16)(17). Additionally, studies have shown that the NPS is more accurate than other prognostic factors in predicting survival (13,14,18).…”

Section: Introductionmentioning

confidence: 99%

Prognostic Importance of the Preoperative Naples Prognostic Score for Patients With Adenocarcinoma of the Esophagogastric Junction

et al. 2020

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BackgroundThe naples prognostic score (NPS) is established according to nutritional or inflammatory state, and it is identified as the new prognostic score for a variety of malignant tumors. However, its significance in cases suffering from adenocarcinoma of esophagogastric junction (AEJ) who receive surgery remains unclear so far.MethodsIn this study, patients receiving surgery without preoperative therapy were examined between June 2007 and August 2017 in a retrospective way. Typically, the serum albumin level, total cholesterol level, neutrophil-to-lymphocyte ratio, together with the lymphocyte-to-monocyte ratio, was determined to calculate the NPS. The prognostic impact of NPS was evaluated using survival analyses. Time-dependent receiver operating characteristic curve (t-ROC) analysis was also carried out for comparing prognostic impacts of those scoring systems.ResultsAltogether 231 cases were enrolled in this study. A higher NPS showed positive correlation with perineural invasion. Upon multivariate analysis, NPS was identified to be the independent prognostic factor to predict overall survival (OS) along with relapse-free survival (RFS) (both P< 0.05), and an especially strong correlation was observed at advanced pTNM stages based on NPS system. As for subgroup analyses on adjuvant chemotherapy or surgery only, NPS still independently predicted the OS as well as RFS (both P< 0.05) in both groups. Furthermore, t-ROC analysis showed that NPS was more accurate than the systemic inflammation score in predicting OS and RFS.ConclusionsThe NPS represents the simple and useful rating system, which can independently predict the survival for AEJ cases undergoing surgery.

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Naples Prognostic Score as a novel prognostic prediction tool in video-assisted thoracoscopic surgery for early-stage lung cancer: a propensity score matching study

Cited by 30 publications

References 25 publications

Naples Prognostic Score: A Novel Prognostic Score in Predicting Cancer-Specific Survival in Patients With Resected Esophageal Squamous Cell Carcinoma

Naples Prognostic Score: A Novel Prognostic Score in Predicting Cancer-Specific Survival in Patients With Resected Esophageal Squamous Cell Carcinoma

Gamma-Glutamyl Transpeptidase to Platelet Ratio Is a Novel and Independent Prognostic Marker for Resectable Lung Cancer: A Propensity Score Matching Study

Prognostic Importance of the Preoperative Naples Prognostic Score for Patients With Adenocarcinoma of the Esophagogastric Junction

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